124 patents
Page 5 of 7
Utility
Systems and Methods for Determining Quantitative Loading of an Integrated Device
28 Apr 22
Aspects of the disclosure relate to techniques for determining a measure of quantitative loading of a sample in an integrated device.
Brian Reed, Haidong Huang
Filed: 26 Oct 21
Utility
Calibration of Single-molecule Detection System
28 Apr 22
Aspects of the present disclosure relate to techniques for calibrating an integrated device.
Thomas Christian, Kyle Preston, Brian Reed, Shannon Stewman
Filed: 26 Oct 21
Utility
Polymerizing enzymes for sequencing reactions
26 Apr 22
Compositions comprising modified recombinant polymerizing enzymes are provided, along with nucleic acid molecules encoding the modified polymerizing enzymes.
Brian Reed, Mohammad Wadud Bhuiya, Manjula Pandey, Jeremy Lackey, Jonathan M. Rothberg, Thomas Christian
Filed: 19 Dec 17
Utility
Optical System and Assay Chip for Probing, Detecting and Analyzing Molecules
21 Apr 22
Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing.
Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyarfas, Jeremy Lackey, Gerard Schmid, Paul E. Glenn, Lawrence C. West, Benjamin Cipriany, Keith G. Fife
Filed: 8 Oct 21
Utility
Optical Rejection Photonic Structures
14 Apr 22
An integrated device and related instruments and systems for analyzing samples in parallel are described.
Jonathan M. Rothberg, Gerard Schmid, Alexander Gondarenko, James Beach, Kyle Preston, Farshid Ghasemi, Jeremy Lackey, Jack Jewell, Keith G. Fife, Ali Kabiri
Filed: 17 Dec 21
Utility
Methods to Minimize Photodamage During Nucleic Acid and Peptide Sequencing
31 Mar 22
Provided herein are methods and integrated devices for improved sequencing of nucleic acid and peptide biomolecules.
Guojun Chen, Thomas Raymond Thurston, An Li
Filed: 21 Sep 21
Utility
Integrated Device with External Light Source for Probing Detecting and Analyzing Molecules
31 Mar 22
System and methods for analyzing single molecules and performing nucleic acid sequencing.
Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyarfas, Jeremy Lackey, Gerard Schmid, Lawrence C. West, Keith G. Fife, Benjamin Cipriany, Farshid Ghasemi
Filed: 8 Oct 21
Utility
Optical system and assay chip for probing, detecting and analyzing molecules
29 Mar 22
Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing.
Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyarfas, Jeremy Lackey, Gerard Schmid, Benjamin Cipriany, Jack Jewell, Lawrence C. West, Michael Ferrigno, Paul E. Glenn, Adam Ezra Cohen, Anthony Bellofiore
Filed: 19 Nov 19
Utility
Methods for Nucleic Acid Sequencing
10 Mar 22
Methods of sequencing molecules based on luminescence lifetimes and/or intensities are provided.
Jonathan M. Rothberg, Jeremy Lackey, Brian Reed, Xinghua Shi, Haidong Huang
Filed: 7 May 21
Utility
System and Method for Detecting Change Points
3 Mar 22
Techniques for evaluating change points in sequencing data during a sequencing reaction is described.
Minh Duc Cao, Mel Davey
Filed: 20 Jul 21
Utility
Method for Isolating Target Nucleic Acid Using Heteroduplex Binding Proteins
24 Feb 22
The invention includes methods and apparatus for separating mutations, especially rare and unknown mutations, using heteroduplex binding proteins.
Andrea Marziali, Milenko Despotovic, Matthew Wiggin, Joel Pel
Filed: 18 Aug 21
Utility
Compact beam shaping and steering assembly
15 Feb 22
Apparatus and methods for coupling an optical beam from an optical source to a hi-tech system are described.
Jonathan M. Rothberg, Paul E. Glenn, Jonathan C. Schultz, Benjamin Cipriany
Filed: 19 Dec 19
Utility
Optical rejection photonic structures using two spatial filters
1 Feb 22
An integrated device and related instruments and systems for analyzing samples in parallel are described.
Jonathan M. Rothberg, Gerard Schmid, Alexander Gondarenko, James Beach, Kyle Preston, Farshid Ghasemi, Jeremy Lackey, Jack Jewell, Keith G. Fife, Ali Kabiri
Filed: 23 Jul 18
Utility
Integrated Photodetector with Direct Binning Pixel
20 Jan 22
An integrated circuit includes a photodetection region configured to receive incident photons.
Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
Filed: 2 Aug 21
Utility
Substrates having modified surface reactivity and antifouling properties in biological reactions
18 Jan 22
Methods of preparing surfaces of sample wells are provided.
Jonathan M. Rothberg, Jeremy Lackey, Guojun Chen
Filed: 4 May 18
Utility
Photonic structures and integrated device for detecting and analyzing molecules
18 Jan 22
System and methods for analyzing single molecules and performing nucleic acid sequencing.
Jonathan M. Rothberg, Ali Kabiri, Gerard Schmid, Keith G. Fife, James Beach, Jason W. Sickler, Lawrence C. West, Paul E. Glenn, Kyle Preston, Farshid Ghasemi, Benjamin Cipriany, Jeremy Lackey
Filed: 1 Jun 17
Utility
Optical Absorption Filter for an Integrated Device
13 Jan 22
Apparatus and methods relating to attenuating excitation radiation incident on a sensor in an integrated device that is used for sample analysis are described.
Michael Bellos, Faisal R. Ahmad, James Beach, Michael Coumans, Sharath Hosali, Ali Kabiri, Kyle Preston, Gerard Schmid, Bing Shen, Jonathan M. Rothberg
Filed: 23 Sep 21
Utility
Integrated device for temporal binning of received photons
28 Dec 21
An integrated circuit includes a photodetection region configured to receive incident photons.
Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
Filed: 4 Aug 20
Utility
CorrectedPolymerizing Enzymes for Sequencing Reactions
23 Dec 21
Compositions comprising modified recombinant polymerizing enzymes are provided, along with nucleic acid molecules encoding the modified polymerizing enzymes.
Brian Reed, Manjula Pandey
Filed: 26 Jun 20
Utility
Fragmentation of Target Molecules for Sequencing
9 Dec 21
Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein.
Jonathan M. Rothberg, John H. Leamon, Jonathan C. Schultz, Michele Millham, Caixia Lv, Haidong Huang, Roger Nani, Omer Ad, Brian Reed, Matthew Dyer, Robert E. Boer
Filed: 21 Apr 21