154 patents
Page 2 of 8
Utility
Three-Dimensional Luminescence Imaging
25 May 23
Systems, apparatuses, and methods are described for 3D luminescence imaging, by identifying a preferred optical pair and optimizing a scanned image using the preferred optical pair.
Joshua Kempner, Jorge Ripoll
Filed: 23 Nov 21
Utility
Low Thermal Mass GC Module
18 May 23
A system and method for performing field-portable GC/MS measurements for the rapid sampling and measurement of high temperature boiling semi-volatile organic compounds in environmental samples, wherein other column bundles have cold spots that may prevent high temperature boiling semi-volatile components from eluting the GC column, this new design may eliminate those cold spots on the GC column.
Edgar D. Lee, Nathan L. Porter, Anthony D. Rands, Randall W. Waite
Filed: 6 Jan 23
Utility
Novel Biomarkers of Membranous Glomerulonephritis
4 May 23
Netrin G1 is disclosed as a biomarker of membranous glomerulonephritis (MGN).
Rolf STAHL, Elion Hoxha, Linda Reinhard
Filed: 13 Oct 22
Utility
Retroviral Transduction Using Poloxamers
27 Apr 23
The present invention relates to a method for transducing a target cell, the method comprising the step of contacting a target cell with a retroviral vector and a poloxamer having a molecular weight of 12.8 kDa to about 15 kDa.
Natasa ANASTASOV, Ines HOFIG, Christian THIRION
Filed: 21 Dec 22
Utility
Conjugated Polymers and Methods of Use
6 Apr 23
The present disclosure provides fluorescent polyindenofluorene polymers or macromers with unique optical properties that are stable.
XINSHE XU, Jing Wang, Matthew Yerou
Filed: 30 Nov 22
Utility
Method and Device for Detecting a Presence of a Fluorescence Pattern Type on an Organ Segment Via Immunofluorescence Microscopy
9 Mar 23
There is proposed a method for detecting a presence of a fluorescence pattern type on an organ segment via immunofluorescence microscopy and digital image processing.
Stefan GERLACH, Jens KRAUTH, Christian MARZAHL, Christopher KRAUSE, Jens HOCKE, Maick DANCKWARDT, Melanie HAHN, Jörn VOIGT
Filed: 25 Aug 22
Utility
ANTI-TLR7 Agents and Compositions and Methods for Making and Using the Same
23 Feb 23
Compositions and methods for making and using anti-TLR7 agents, for example, monoclonal antibodies, TLR7-binding antibody fragments, and derivatives are described, as are kits, nucleic acids encoding such molecules, diagnostic reagents and kits that include anti-TLR7 agents, and methods of making and using the same.
TAKATOKU OIDA, ANAGHA ASHOK DIVEKAR, SHAWNA ANN SHIRLEY, NICOLE VIVIENNE ACUFF
Filed: 9 Jul 22
Utility
Active Grinding Media for Processing Samples
9 Feb 23
An active/resilient grinding media inside a tube containing a sample is oscillated rapidly by a homogenizer so that the active media is driven in a first direction until it impacts a first end of the tube, which causes it to deform and store an energy charge as it decelerates and stops, and it then accelerates rapidly in the second opposite direction under the discharging force of the stored energy toward the opposite second end of the tube.
William Z. Todd, Karl Jahn
Filed: 19 Oct 22
Utility
Method for the Qualitative Evaluation of Real-time PCR Data
26 Jan 23
A method is used for the qualitative evaluation of real-time PCR data, where a time/PCR amplification plot of an associated sample is classified as a negative plot or as a positive plot.
Christodoulos Filippis, Ulf Steller, Fiona Schilling
Filed: 18 Dec 20
Utility
Heat Management for Inductively Coupled Plasma Systems
26 Jan 23
A system for cooling an inductively coupled plasma (ICP) instrument includes: the ICP instrument; a pump in fluid communication with the instrument via a first conduit; and a micro-channel heat exchanger in fluid communication with the instrument via a second conduit, and in fluid communication with the pump via a third conduit.
Tak Shun Cheung, Chui Ha Cindy Wong, William Fisher, Hamid Badiei
Filed: 22 Jul 21
Utility
LCMS with Esi Source for Enhanced Sensitivity of Compounds
12 Jan 23
This disclosure provides liquid chromatography tandem mass spectrometer (LC-MS/MS) methods and systems for detecting low levels of pesticides in a test sample.
Avinash Dalmia
Filed: 9 Jul 21
Utility
Assessment of an Analyte from a Biological Sample Disposed on a Support
29 Dec 22
Methods of assessing an analyte in a blood sample are provided according to aspects of the present disclosure which include: extracting the analyte from a biological sample dried on a treated support, producing an extracted sample, the treated support comprising a protein denaturant, wherein the analyte is a substrate for an enzyme present, or suspected of being present, in the biological sample, wherein the protein denaturant inhibits enzymatic activity of the enzyme on the analyte; and subjecting the extracted sample to liquid chromatography tandem mass spectrometry (LC/MS/MS), thereby assessing the analyte in the biological sample.
Sara Smith, Erica Fox
Filed: 28 Jun 21
Utility
Method for Detecting an Error State When Aspirating a Liquid
22 Dec 22
A method is proposed for detecting an error state when aspirating a liquid, including: immersing a tip of an aspiration needle in the liquid, generating a negative pressure in the aspiration needle for a predefined time period to aspirate a predetermined partial volume of the liquid in the aspiration needle, continuously acquiring a sensor signal curve by means of continuous measurement of a sensor signal, which indicates a pressure in the aspiration needle, during an overall time period, which comprises the predetermined time period and furthermore a further time period following the predetermined time period, detecting the error state in the case that the sensor signal falls below a first threshold value during the predetermined time period, characterized by providing a reference signal curve, determining a deviation measure, which indicates a deviation of the sensor signal curve from the reference signal curve during the further time period, providing a predetermined second threshold value, detecting the error state as a function of the deviation measure and the second threshold value.
Danny FARELL, Anna Katharina LAARMANN
Filed: 18 Jun 22
Utility
RepublicationMethod and apparatus for detecting a presence of a fluorescence pattern type on an organ section by means of immunofluorescence microscopy
22 Dec 22
A method for detecting at least one potential presence of at least one fluorescence pattern type on an organ section by means of immunofluorescence microscopy and by means of digital image processing is disclosed.
Jens Krauth, Stefan Gerlach, Christian Marzahl, Christopher Krause, Jens Hocke, Melanie Hahn, Joern Voigt
Filed: 21 Dec 21
Utility
Apparatus and Method for Detecting Coverslip Regions of a Specimen Slide
22 Dec 22
An apparatus is proposed for identifying respective cover slip regions of respective cover slips having respective tissue sections on a specimen slide, which has multiple optical identifiers.
Christian FEIRER, Erik Bernitt-Ringering, Martin RATEIKE, Simon SCHWAB, Winfried STÖCKER
Filed: 17 Dec 20
Utility
Enhancing LCMS Analyte Signals
15 Dec 22
This disclosure provides liquid chromatography tandem mass spectrometer (LC-MS/MS) methods and systems for detecting low levels of pesticides and mycotoxins in a test sample.
Avinash Dalmia
Filed: 15 Jun 21
Utility
Mixing Liquids Using an Automated Liquid Handling System
15 Dec 22
A method for mixing liquids using an automated liquid handling system includes: aspirating liquid volumes of a first liquid and a second liquid from alternating ones of a first liquid supply and a second liquid supply into a mixing volume such that the aspirated liquid volumes form a liquid stack including a series of alternating, interfacing layers of the first and second liquids in the mixing volume; permitting the interfacing layers of the first and second liquids to mix with one another by diffusion in the mixing volume to form a mixture liquid; and dispensing the mixture liquid from the mixing volume.
Adam Snider, Andrew Brodsky
Filed: 9 Jun 21
Utility
Cross-contamination control
1 Dec 22
A nucleic acid or peptide detection system that includes a carrier with at least two areas is provided.
Ulf Steller, Susanne Zieseniss, Jenny Voss
Filed: 25 May 22
Utility
Methods and Kits for Depleting Undesired Nucleic Acids
1 Dec 22
Methods and kits for depleting amplicons that correspond to undesired RNA species present in a sample are provided.
Suk Ho Eun, Adam R. Morris
Filed: 11 Aug 22
Utility
Mass Spectrometer Apparatus Including Ion Detection to Minimize Differential Drift
3 Nov 22
A mass spectrometry apparatus includes an ion detector and a control circuit coupled to the ion detector.
William Fisher, Bohdan Atamanchuk, Hamid R. Badiei
Filed: 30 Apr 21