154 patents
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Utility
Method and means for detecting an autoantibody
6 Oct 22
A method can be used for detecting, in a sample, an autoantibody binding to a polypeptide having the sequence SEQ ID NO: 1, SEQ ID NO: 11 or SEQ ID NO: 24.
Zitao ZENG, Lars Komorowski, Ramona Miske, Madeleine Scharf, Yvonne Denno, Christiane Radzimski, Nadine Rochow, Stefanie Brakopp
Filed: 23 Mar 22
Utility
Method and reagents for the detection of an autoantibody
29 Sep 22
A method involves detecting in a sample an autoantibody binding specifically to a mammalian VGLUT.
Ramona MISKE, Christiane Radzimski, Kathrin Margalene Borowski, Yvonne Denno
Filed: 25 Mar 22
Utility
Universal Blocking Oligonucleotides for Reduced Off-target Hybridization In Hybridization Capture Methods
8 Sep 22
Sets of hybridization blockers, kits include at least one set of hybridization blockers, and methods of use thereof in massively parallel nucleic acid sequencing, are provided according to aspects of the present disclosure, each of the hybridization blockers comprising at least one Tm increasing nucleotide, the set of hybridization blockers for use in massively parallel sequencing of a plurality of nucleic acid sequencing library molecules, wherein the set of hybridization blockers efficiently blocks the complementary strand interactions between the adapter regions of different library molecules and is therefore effective to reduce the capture of non-target sequences during a capture enrichment hybridization to maximize the efficiency of the massively parallel sequencing techniques.
Kerry Gunning
Filed: 7 Mar 22
Utility
Methods and Systems for Quantifying Two or More Analytes Using Mass Spectrometry
18 Aug 22
Certain embodiments described herein are directed to methods and systems of detecting two or more analytes present in a single system such as a nanoparticle or nanostructure.
Samad Bazargan, Hamid Badiei
Filed: 27 Sep 21
Utility
PDMS Granular Coated Vial
28 Jul 22
The present invention is a system and method for improving extraction of analytes from a solution by disposing a plurality of polydimethylsiloxane(PDMS) particles in a thin layer on an inner wall of an extraction vial, by increasing a surface area and volume of particles disposed to extract analytes from the solution and thereby increasing extraction capacity and speed for gas chromatography-mass spectrometry (GC-MS) analysis.
Tai Van Truong, Nathan Porter, Edgar D. Lee
Filed: 1 Jul 20
Utility
Method of detecting presences of different antinuclear antibody fluorescence pattern types without counterstaining and apparatus therefor
21 Jul 22
A method and apparatus are provided for detecting respective potential presences of respective different cellular fluorescence pattern types on a biological cellular substrate including human epithelioma cells (HEp cells), wherein the fluorescence pattern types include different antinuclear antibody fluorescence pattern types.
Christopher Krause, Jens Krauth, Stefan Gerlach, Christian Marzahl, Melanie Hahn, Joern Voigt
Filed: 19 Jan 22
Utility
Inductively Coupled Plasma Torches and Methods and Systems Including Same
21 Jul 22
An ICP torch includes an injector tube defining an injector flow passage to receive a flow of a sample fluid, an intermediate tube disposed about the injector tube, a plasma tube disposed about the intermediate tube, and an induction coil disposed about the plasma tube.
Tak Shun Cheung, Chui Ha Cindy Wong, William Fisher, Hamid R. Badiei
Filed: 19 Jan 21
Utility
Finger-Tight Gas Chromatograph (GC) Column Connections
21 Jul 22
A gas chromatograph (GC) column connection device includes a housing including first and second opposite ends, the housing including a housing bore extending therethrough between the first and second ends of the housing.
Samuel Tolley, Christopher Bailey
Filed: 11 Jan 22
Utility
Systems and Methods for Emulating Scintillation Events Using an Electronic Test Source
21 Jul 22
Presented herein are systems and methods that provide for calibration and/or testing of liquid scintillation counters (LSCs) using an electronic test source.
Richard Harazin
Filed: 1 Feb 22
Utility
Echelle Spectrometer
14 Jul 22
Spectrometers include an optical assembly with optical elements arranged to receive light from a light source and direct the light along a light path to a multi-element detector, dispersing light of different wavelengths to different spatial locations on the multi-element detector.
David M. Aikens
Filed: 14 Oct 21
Utility
Assay for the Diagnosis of Dermatophytosis
30 Jun 22
A primer pair that includes a forward primer and a reverse primer is used to amplify a nucleic acid from a pathogen associated with a skin, hair and nail infection that includes SEQ ID NO: 22.
Melanie HARDER, Yvonne Gräser, Christiane Kupsch, Markus Cavalar
Filed: 14 Mar 22
Utility
Detecting a Target Nucleic Acid In a Biological Sample
23 Jun 22
Provided herein are methods, compositions, and kits for detecting a target nucleic acid, such as from a virus, in a biological sample.
Yanhong Tong, Macy Veling, Eleanore Dougherty
Filed: 20 Dec 21
Utility
Method and apparatus for detecting a presence of a fluorescence pattern type on an organ section by means of immunofluorescence microscopy
23 Jun 22
A method for detecting at least one potential presence of at least one fluorescence pattern type on an organ section by means of immunofluorescence microscopy and by means of digital image processing is disclosed.
Jens Krauth, Stefan Gerlach, Christian Marzahl, Christopher Krause, Jens Hocke, Melanie Hahn, Joern Voigt
Filed: 21 Dec 21
Utility
Method and reagents for diagnosing Membranous Nephropathy
16 Jun 22
Provide are a diagnostically useful carrier coated with a recombinant polypeptide comprising SEQ ID NO: 1, an isolated autoantibody binding specifically to a polypeptide having SEQ ID NO: 1, a kit comprising the carrier, a method for the diagnosis of a membranous nephropathy (MN) that includes detecting the presence or absence of an autoantibody binding specifically to a polypeptide having SEQ ID NO: 1 in a liquid sample comprising antibodies from a subject, a use of an autoantibody binding specifically to a polypeptide having SEQ ID NO: 1 or a polypeptide comprising SEQ ID NO: 1, and a aqueous solution comprising an autoantibody binding specifically to a polypeptide having SEQ ID NO: 1.
Inga-Madeleine DETTMANN, Swantje MINDORF, Christian PROBST
Filed: 2 Dec 21
Utility
Chromatography Systems and Methods Using Them
5 May 22
Certain embodiments described herein are directed to chromatography systems that include a microfluidic device.
Andrew Tipler
Filed: 2 Aug 21
Utility
Discharge Chambers and Ionization Devices, Methods and Systems Using Them
31 Mar 22
Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described.
Mehrnaz Sarrafzadeh, Gholamreza Javahery, Charles Jolliffe, Lisa Cousins
Filed: 6 Jun 21
Utility
Viral Transduction Using Poloxamines
24 Mar 22
The present invention relates to a composition comprising or consisting of (a) a poloxamine; and (b)(i) retroviral vector; and/or (ii) a vertebrate cell.
Christian THIRION, Stefan HASENÖDER, Silke SCHRÖDEL
Filed: 4 Dec 19
Utility
Single Drive Positioning Systems and Methods and Mass Analysis Systems Including Same
24 Mar 22
A single drive positioning system includes a drive shaft, a motor, a first worm screw, and a second worm screw.
Matthew Hassenbach
Filed: 31 Aug 21
Utility
Method for detecting a binding of antibodies from a patient sample to double-stranded DNA using Crithidia luciliae cells and fluorescence microscopy
17 Mar 22
There is proposed a method for detecting a binding of autoantibodies from a patient sample to double-stranded deoxyribonucleic acid using Crithidia luciliae cells by means of fluorescence microscopy, including the steps of: provision of a substrate which has multiple Crithidia luciliae cells, incubation of the substrate with the patient sample which potentially has the autoantibodies, incubation of the substrate with secondary antibodies which have each been labelled with a preferably green fluorescent dye, acquisition of a fluorescence image of the substrate, identification by means of a first pretrained convolutional neural network of respective sub-images in the one fluorescence image that each represent a Crithidia luciliae cell, furthermore respective processing of at least one subset of the respective sub-images by means of a second pretrained convolutional neural network for determining respective binding measures which indicate a respective extent of a binding of autoantibodies in a respective kinetoplast region of a respective Crithidia luciliae cell of a respective sub-image, and determination of an overall binding measure with regard to a binding of autoantibodies from the patient sample to double-stranded deoxyribonucleic acid on the basis of the respective binding measures.
Stefan Gerlach, Jens Krauth, Christian Marzahl, Christopher Krause, Maick Danckwardt, Melanie Hahn, Jörn Voigt
Filed: 17 Sep 21
Utility
Aav-based Conditional Expression System
10 Mar 22
The present invention relates to a cell comprising (aa) a nucleic acid comprising in 5′ to 3′ direction (i) at least one adeno-associated virus (AAV) inverted terminal repeat (ITR) sequence; (ii) a promoter which is capable of being activated by (a) helper polypeptide(s) and optionally (a) helper polynucleotide(s); and (iii) a transgenic coding sequence under the control of said promoter of (aa)(ii); and (ab) a nucleic acid comprising in 5′ to 3′ direction (i) a promoter which is capable of being activated by said helper polypeptide(s) and optionally said helper polynucleotide(s); and (ii) at least one AAV rep gene coding sequence under the control of said promoter of (ab)(i); wherein said cell does not comprise an AAV cap gene and/or is not able to express any AAV cap gene product.
Ulrich KOSZINOWSKI, Simona LANGER, Zsolt RUZSICS, Christian THIRION
Filed: 22 Sep 21