1919 patents
Page 2 of 96
Utility
Device and Method for Fenestration Alignment
4 Jan 24
Patient-specific implants with fenestration(s) positioned at locations specific to patient's anatomy at the site of implantation are made using automated methods for making the patient-specific implants through fenestration alignment.
Tom McGlennon Dillon, Patric Liang, Ellen Roche, Marc Schermerhorn
Filed: 23 Nov 21
Utility
System and Method of Conditional Neural Floorplans for Static-dynamic Disentanglement
4 Jan 24
A method of conditional neural ground planes for static-dynamic disentanglement is described.
Prafull SHARMA, Ayush TEWARI, Yilun DU, Sergey ZAKHAROV, Rares Andrei AMBRUS, Adrien David GAIDON, William Tafel FREEMAN, Frederic Pierre DURAND, Joshua B. TENENBAUM, Vincent SITZMANN
Filed: 18 Apr 23
Utility
Potassium-releasing Material
4 Jan 24
The present disclosure, in various embodiments, discloses hydrothermal methods, hydrothermally modified materials and dried hydrothermally modified materials.
Davide Ciceri, Marcelo de Oliveira, Antoine Allanore, Dennis P. Chen, Thomas C. Close
Filed: 17 May 23
Utility
Use of Brain Organoids and Single Cell Genomics to Understand and Treat Neurodevelopmental and Neuropsychiatric Disorders
4 Jan 24
The present disclosure is directed to methods of screening for pathological mechanisms in neurodevelopmental and neuropsychological disorders using brain organoids.
Paola Arlotta, Joshua Z. Levin, Amanda J. Kedaigle, Aviv Regev, Bruna Da Silveira Paulsen, Silvia Velasco, Martina Pigoni
Filed: 1 Nov 21
Utility
Return Flow System for Ion Concentration Polarization (ICP)
28 Dec 23
A device for purifying and/or concentrating a first water stream containing ionic impurities includes a first and second ion exchange membrane and a first porous membrane.
Jongyoon Han, Junghyo Yoon
Filed: 1 Sep 23
Utility
Transmucosal Amphiphile-protein Conjugate Vaccine
28 Dec 23
What is disclosed is a vaccine comprising an immunogen conjugated to an albumin-binding polymer-lipid tail, wherein the vaccine is suitable for transmucosal (e.g, intranasal) administration.
Darrell J. Irvine, Brittany L. Hartwell
Filed: 6 Mar 23
Utility
Crosslinking Comonomers for High Performance Degradable Thermosets
28 Dec 23
Jeremiah A. Johnson, Peyton Shieh, Keith Husted
Filed: 9 Nov 21
Utility
Enhanced Crystal Nucleation
28 Dec 23
Crystal nucleation, and associated articles, systems, and methods, are generally described.
Kripa K. Varanasi, Henri-Louis Girard, Caroline McCue
Filed: 26 May 23
Utility
Digital Crispr-based Method for the Rapid Detection and Absolute Quantification of Nucleic Acids
28 Dec 23
The present invention relates to a digital CRISPR-based method for detecting and quantitating target nucleic acids in a sample comprising: forming a mixture comprising sample nucleic acids; isothermal amplification reaction reagents for amplifying one or more target nucleic acid sequences; partitioning the mixture into a plurality of compartments; incubating the partitioned mixture at a temperature for isothermal amplification and Cas effector cleavage of an amplified DNA strand, detecting a signal from cleavage of the non-target sequence, thereby detecting the one or more target sequences in the sample, and determining the copy number of the target nucleic acid based on a Poisson distribution of the proportion of positive-to-negative compartments.
Xiaolin Wu, Hanry Yu, Timothy Kuan-ta Lu
Filed: 28 Oct 21
Utility
Engineered Chimeric Antimicrobial Agents Against Gram-positive Bacteria
28 Dec 23
The present invention relates to chimeric bacteriophage lysins which can be used to sanitize surfaces, for the treatment of bacterial infections and/or for the selective treatment of body odor-causing bacteria.
Boon Chong GOH
Filed: 14 Nov 21
Utility
Variable Inverter/Rectifier/Transformer
28 Dec 23
Described is a hybrid electronic and magnetic structure that enables a transformer with fractional and reconfigurable effective turns ratios (e.g. 12:0.5, 12:2/3, 12:1, and 12:2) and hereinafter referred to as a Variable-Inverter-Rectifier-Transformer (VIRT).
David J. Perreault, Mike Kavian Ranjram, Intae Moon
Filed: 22 Jun 23
Utility
System for Legal Precedent Prediction & Related Techniques
28 Dec 23
Described is a system and technique for identifying passages of legal precedent and assembling arguments that use this precedent.
Robert Zev MAHARI, Alex Paul PENTLAND
Filed: 28 Jun 22
Utility
Methods for Identifying Drivers of Immune Responses Using Molecular Expression Signatures of Immunomodulating Agents
21 Dec 23
The present disclosure provides methods for determining signatures of immune responses to immunomodulating agents in cells and in tissues.
Nir Hacohen, Ang Cui
Filed: 4 Nov 21
Utility
Systems and Methods for Compact, Decentralized Desalination of Feedwater for Point-of-use Applications
21 Dec 23
Systems and methods for configuring compact desalination RO systems operable for point-of-use applications are disclosed herein.
Quantum J. WEI, Sahil Rajesh SHAH, Grace Bethea CONNORS
Filed: 30 Nov 21
Utility
Engineered Protein for Rapid, Efficient Capture of Pathogen-specific Antibodies
21 Dec 23
The present disclosure relates to proteins comprising a target-binding domain for detection of anti-SARS-CoV-2 antibodies, methods, compositions and kits thereof.
Hadley Sikes Johnson, Eric Alexander Miller, Seunghyeon Kim
Filed: 10 Nov 21
Utility
Hemostatic Nanoparticles for the Treatment of Non-compressible Hemorrhage and Internal Bleeding
21 Dec 23
An injectable nanoparticular formulation and method of use thereof for treating non-compressible hemorrhage or internal bleeding has been developed.
Paula T. Hammond Cunningham, Bradley D. Olsen, George Velmahos, Celestine Jia Huey Hong
Filed: 15 Feb 23
Utility
Programmable Gene Editing Using Guide Rna Pair
21 Dec 23
Provided herein are compositions, methods, and systems comprising a DNA binding nickase, a reverse transcriptase, an integration enzyme, and a guide RNA pair.
Omar Abudayyeh, Jonathan Gootenberg
Filed: 19 Apr 23
Utility
Methods and Apparatus for Imaging with Conformable Ultrasound Patch
14 Dec 23
An ultrasound patch may conform to a curved surface of a large, curvilinear part of a human body, and may capture ultrasound images of underlying tissue for detection of disease.
Canan Dagdeviren, Lin Zhang
Filed: 30 Aug 23
Utility
Electrochemical Formation of Substrate Coatings
14 Dec 23
Systems, articles, and methods generally related to the electrochemical formation of layers comprising halogen ions on substrates are described.
Betar Gallant, Haining Gao
Filed: 28 Aug 23
Utility
Metal-organic Framework Mediated Macromolecule Delivery System
14 Dec 23
Articles and methods related to the administration of biomolecules to subjects using metal-organic frameworks are generally described.
Robert S. Langer, Carlo Giovanni Traverso, Adam Wentworth, Xiaoyue Qi
Filed: 10 Nov 21