1919 patents
Page 5 of 96
Utility
Compositions and Methods of Use of Crispr-cas Systems In Nucleotide Repeat Disorders
16 Nov 23
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences.
Feng ZHANG, Beverly DAVIDSON, Chie-Yu LIN, Edgardo RODRIGUEZ
Filed: 8 Feb 23
Utility
Activatable Therapeutic Peptides and Uses Thereof
16 Nov 23
Disclosed herein are fusion protein, comprising (a) at least one X1 domain comprising a half-life extension compound, including but not limited to a half-life extension polypeptide; (b) at least one X2 domain comprising an anionic block; (c) at least one X3 domain comprising a linker susceptible to cleavage at a site of disease, including but not limited to a microbial infection site or tumor site; and (d) at least one X4 domain comprising a therapeutic peptide; wherein the at least one X1, X2, X3, and X4 domains are covalently linked, and each X4 domain is linked to an X3 domain without an intervening X1 or X2 domain; compositions containing such fusion proteins, and methods for their use.
Sangeeta N. BHATIA, Chayanon NGAMBENJAWONG
Filed: 10 Mar 23
Utility
Catalytic process for selective polyolefin hydrogenolysis
16 Nov 23
Yuriy ROMÁN, Julie RORRER, Guido ZICHITTELLA, Gregg Tyler BECKHAM
Filed: 10 May 23
Utility
Leaf Spring with High Resolution Stiffness Control
16 Nov 23
A variable stiffness leaf spring mechanism and method of locking parallel leaf springs allow for a wide range of stiffness settings in a low-mass package.
Hugh M. Herr, Emily Ann Rogers-Bradley
Filed: 8 Sep 21
Utility
Cable Joint for Superconducting Cables and Related Techniques
9 Nov 23
Described are cable joints and related structures and techniques for coupling high temperature superconducting (HTS) cables.
Zachary HARTWIG, Philip MICHAEL, Brandon N. SORBOM, James IRBY, Rui VIEIRA, William BECK, Erica SALAZAR, Vincent FRY
Filed: 2 Dec 20
Utility
Molecule Selection Using Simulation and Ranking Based on Binding Matrices
9 Nov 23
A computer-implemented method calculates the affinity and templating ability of a molecule for a nanoporous host framework using a multi-factor index that uses simulation outcomes as component indices.
Rafael Gomez-Bombarelli, Daniel Schwalbe-Koda
Filed: 11 Jan 23
Utility
Three-dimensional Machine Knitting of Electronic Textile for Activity Recognition and Biomechanical Monitoring
9 Nov 23
Disclosed herein are systems and techniques for seamless and scalable piezoresistive matrix-based intelligent textile development using digital flat-bed and circular knitting machines.
Joseph A. Paradiso, Irmandy Wicaksono
Filed: 3 May 23
Utility
Solid-state Battery and Method of Manufacturing Solid-state Battery Utilizing Spray Pyrolysis
9 Nov 23
An electrochemical cell and a method of manufacturing the electrochemical cell are provided.
Andrea Maurano, Jesse John Hinricher, So Yeon Kim, Jennifer Lilia Marguerite Rupp, Ju Li, Yuntong Zhu, Hyunwon Chu, Zachary David Hood, Won Seok Chang, Kai Pei, Yimeng Huang, Srinath Chakravarthy, Ziqiang Wang
Filed: 16 May 22
Utility
Engineered Binding Proteins for Recognition of Bacteria
9 Nov 23
Described herein are antigen-binding molecules that bind to bacteria (e.g., Listeria monocytogenes) and methods of use thereof.
Hadley Sikes Johnson, Ki-Joo Sung, Yining Hao
Filed: 23 Sep 21
Utility
Tissue-Integrating Neural Interfaces
9 Nov 23
Solvent evaporation or entrapment-driven (SEED) integration is a rapid, robust, and modular approach to creating multifunctional fiber-based neural interfaces.
Anthony Tabet, Polina Olegovna ANIKEEVA
Filed: 9 May 23
Utility
Nanobody Based Imaging and Targeting of Ecm In Disease and Development
2 Nov 23
Methods for developing disease-related nanobodies and related products and kits are provided.
Richard O. Hynes, Noor Jailkhani, Hidde L. Ploegh, Yushu J. Xie
Filed: 28 Feb 23
Utility
Compositions and Methods for Combinatorial Drug Discovery In Nanoliter Droplets
2 Nov 23
The present disclosure relates compositions and methods for combinatorial drug discovery in nanoliter droplets.
Paul Blainey, Anthony Kulesa, Jared Kehe
Filed: 19 Dec 22
Utility
Power Converter with Capacitive Energy Transfer and Fast Dynamic Response
2 Nov 23
A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage.
David M. GIULIANO, David J. PERREAULT, Robert C.N. PILAWA-PODGURSKI
Filed: 28 Jun 23
Utility
Nanostructured Gels Capable of Controlled Release of Encapsulated Agents
2 Nov 23
Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described.
Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer
Filed: 1 May 23
Utility
Spiral Inertial Microfluidic Devices and Methods to Remove Contaminants
2 Nov 23
A spiral inertial microfluidics device has been designed for use as a microfluidic sorting device.
Kyungyong Choi, Jongyoon Han, Stacy L. Springs
Filed: 24 Feb 23
Utility
Single Cell Sequencing Libraries of Genomic Transcript Regions of Interest In Proximity to Barcodes, and Genotyping of Said Libraries
2 Nov 23
The present invention relates to methods of detecting region(s) of interest in a gene comprising a polyA tail.
Peter van Galen, Volker Hovestadt, Travis Hughes, Marc H. Wadsworth II, Bradley Bernstein, Alexander K. Shalek, Todd M. Gierahn, J. Christopher Love, Ang A. Tu
Filed: 13 Jun 23
Utility
All-Photonic Artificial Neural Network Processor Via Nonlinear Optics
2 Nov 23
An all-photonic computational accelerator encodes information in the amplitudes of frequency modes stored in a ring resonator.
Jasvith Raj Basani, Mikkel HEUCK, Dirk Robert ENGLUND, Stefan Ivanov Krastanov
Filed: 2 May 23
Utility
Alkenyl Substituted 2,5-PIPERAZINEDIONES, Compositions, and Uses Thereof
26 Oct 23
Daniel Griffith Anderson, Joseph R. Dorkin, Owen Shea Fenton, Kevin John Kauffman, Rebecca L. McClellan
Filed: 2 May 23
Utility
Spectrally Multiplexed Solid State Quantum Emitters and Memories for Quantum Repeaters
26 Oct 23
A spectrally multiplexed quantum repeater (SMuQR) based on spatially arrayed nodes of frequency-multiplexed multi-qubit registers uses the natural inhomogeneous distribution of optical transition frequencies in solid state defect centers.
Eric Alexander Bersin, Carlos Errando Herranz, Dirk Robert ENGLUND
Filed: 26 Aug 21
Utility
Zero-Added-Loss Entangled Photon Multiplexing Source
26 Oct 23
We disclose optical entanglement distribution in quantum networks based on a quasi-deterministic entangled photon pair source.
Kevin Chen, Prajit Dhara, Saikat Guha, Dirk Robert ENGLUND
Filed: 22 Feb 23