151 patents
Utility
Lateral Flow Devices for High Sensitivity Detection of Coronavirus Infection, and Methods of Making and Using the Same
18 Jan 24
The present disclosure provides, inter alia, a lateral flow device, and methods of use of the device, for accurately and rapidly detecting the presence of a coronavirus or a coronavirus infection in a subject, such as a SARS-CoV-2 virus or virus infection.
Henry Hongjun Ji
Filed: 3 Nov 21
Utility
Neutralizing Antibodies that Bind the SARS-COV-2 S Protein
28 Dec 23
The present disclosure provides fully human antibodies that specifically bind the spike (S) protein of the SARS-CoV-2 coronavirus with high affinity, or antigen-binding proteins derived from such antibodies, and uses thereof.
Henry Hongjun Ji, Robert Allen, Heyue Zhou, Yanliang Zhang, Yanwen Fu, Wenzhong Guo, Hui Xie, Xia Cao, Lucy Lu, Donghui Li, Reyna Lim, Arthur Ledesma, Daniel Lee
Filed: 6 Aug 21
Utility
Neutralizing Antibodies that Bind the SARS-COV-2 S Protein
21 Dec 23
The present disclosure provides antigen-binding proteins, such as fully human antibodies, that specifically bind the spike (S) protein of the SARS-CoV-2 coronavirus and uses thereof.
Heyue Zhou, Xia Cao, Lucy Lu, Ying Yan, Yanliang Zhang, Henry Hongjun Ji, Robert Allen
Filed: 5 May 21
Utility
Oncolytic Herpes Simplex Viruses (HSV) Expressing Immunomodulatory Fusion Proteins
9 Nov 23
Recombinant oncolytic viruses that produce and secrete novel immunomodulatory fusion proteins are described.
Robert ALLEN, Colin POWERS, Gunnar KAUFMANN, Joe CONNER
Filed: 25 Jun 21
Utility
Fluid Delivery Apparatus with Microneedles
2 Nov 23
Disclosed herein are devices and methods for delivering a fluidic composition across a dermal barrier of a subject, e.g., into the lymphatic vasculature of the subject.
Russell Frederick Ross
Filed: 2 Dec 20
Utility
Variant antibodies that bind OX40
3 Oct 23
The present disclosure provides variant anti-OX40 antibodies that mimic the activity of OX40L by behaving as an agonist against receptor OX40 to enhance T cell clonal expansion and differentiation.
Min Soo Kim
Filed: 23 Aug 21
Utility
Treating Pulmonary Inflammatory Disease by Neural Ablation
28 Sep 23
There is disclosed a method for treating pulmonary inflammatory disease by neural ablation methods.
Alexis G. Nahama
Filed: 10 Aug 21
Utility
CD-38 directed chimeric antigen receptor constructs
19 Sep 23
There is disclosed compositions and methods relating to or derived from anti-CD38 antibodies.
Yanliang Zhang, Heyue Zhou, Qianzhong Ma
Filed: 2 Nov 18
Utility
Microneedle array assembly and fluid delivery apparatus having such an assembly
5 Sep 23
A microneedle array assembly includes a microneedle array that has a plurality of microneedles.
Andrew T. Baker, Russell F. Ross
Filed: 21 Mar 22
Utility
Antibody therapeutics that bind CD123
5 Sep 23
There is disclosed compositions and methods relating to or derived from anti-CD123 antibodies.
Heyue Zhou, John Dixon Gray
Filed: 15 Jan 21
Utility
Administration of Resiniferatoxin For Treatment of Bladder Pain or Bladder Cancer
31 Aug 23
Disclosed herein are methods of administering resiniferatoxin (RTX) intravesically for treatment of bladder pain, and compositions for use in such methods.
Alexis Nahama, Henry Hongjun Ji
Filed: 18 Jun 21
Utility
ANTI-PD1 Antibodies and Uses Thereof
27 Jul 23
The present disclosure provides PD-1 binding proteins, particularly anti-PD-1 antibodies, or antigen-binding portions thereof, that specifically bind PD-1 and uses thereof.
Heyue ZHOU, Priscilla TANG, Damien BRESSON, Barbara SWANSON, Alok SINGH, Lisa KERWIN
Filed: 25 Jun 21
Utility
Pulmonary Administration of ACE2 Polypeptides
25 May 23
The present disclosure provides methods for treating a subject having a coronavirus infection by administering a composition that includes a sACE2 polypeptide to the lungs of a subject infected with a coronavirus.
Yanwen Fu, Yanliang Zhang, Heyue Zhou, Namir Shaabani, Reyna Lim, Yan Li, Chin-I Pai
Filed: 20 Apr 21
Utility
Application Device for a Fluid Delivery Apparatus and Method of Use
18 May 23
An application device for a fluid delivery includes a housing having a bore extending from a bottom of the housing.
Russell F. Ross, Luke Hagan, Aaron Peck, Alyson Yamada, Pratap Ganapathy
Filed: 19 Jan 23
Utility
Engineered Antibodies That Bind LAG3
11 May 23
The present disclosure provides fully human anti-LAG3 IgG class antibodies engineered to have amino acid sequence in their heavy chain variable region and/or light chain variable region to improve antigen binding, cell binding, T cell activation and cytokine release capabilities.
Damien Bresson, Min Soo Kim, Heyue Zhou, John Dixon Gray, Barbara A. Swanson, Alok Singh, Lisa Diane Kerwin
Filed: 1 Apr 21
Utility
Treating Pulmonary Inflammatory Disease Associated With Covid-19 By Administering Resiniferatoxin
11 May 23
There is disclosed a method for treating pulmonary inflammatory disease comprising administering an effective amount of resiniferatoxin (RTX) by an epidural, peri-ganglionic or intra-ganglionic administration.
Alexis Nahama, Henry Hongjun Ji, Irving H. Zucker, Hanjun Wang
Filed: 12 Mar 21
Utility
Device for Delivery of Rheumatoid Arthritis Medication
4 May 23
Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier.
Russell Frederick Ross
Filed: 29 Dec 22
Utility
Anti-OX40 binding proteins
11 Apr 23
The present disclosure provides anti-OX40 antibodies, and antigen-binding portions thereof.
Damien Bresson
Filed: 17 Aug 20
Utility
Innate Immunity Killer Cells Targeting PSMA Positive Tumor Cells
30 Mar 23
The present disclosure provides an innate immunity cell such as a gamma delta T (gdT) cell, Natural Killer (NK) cell, or macrophage having 2-[3-(1,3-dicarboxypropyl)ureido] pentanedioic acid (DUPA) chemically conjugated to the cell surface.
Yanwen Fu, Reyna Lim, Daniel Lee, Matthew Buschman, Tong Zhu, Alisher B. Khasanov
Filed: 5 Mar 21
Utility
Anti-cancer phosphorothioate-coupled peptide conjugates and methods of using the same
21 Mar 23
Provided herein are, inter alia, nucleic acid-peptide conjugates including a non-cell penetrating protein (e.g., an Hdm2 targeting peptide) attached at its C-terminus to a phosphorothioate nucleic acid.
Andreas Herrmann, Hua Yu, Yanwen Fu
Filed: 13 Jul 18