83 patents
Utility
Lateral Flow Devices for High Sensitivity Detection of Coronavirus Infection, and Methods of Making and Using the Same
18 Jan 24
The present disclosure provides, inter alia, a lateral flow device, and methods of use of the device, for accurately and rapidly detecting the presence of a coronavirus or a coronavirus infection in a subject, such as a SARS-CoV-2 virus or virus infection.
Henry Hongjun Ji
Filed: 3 Nov 21
Utility
Neutralizing Antibodies that Bind the SARS-COV-2 S Protein
28 Dec 23
The present disclosure provides fully human antibodies that specifically bind the spike (S) protein of the SARS-CoV-2 coronavirus with high affinity, or antigen-binding proteins derived from such antibodies, and uses thereof.
Henry Hongjun Ji, Robert Allen, Heyue Zhou, Yanliang Zhang, Yanwen Fu, Wenzhong Guo, Hui Xie, Xia Cao, Lucy Lu, Donghui Li, Reyna Lim, Arthur Ledesma, Daniel Lee
Filed: 6 Aug 21
Utility
Neutralizing Antibodies that Bind the SARS-COV-2 S Protein
21 Dec 23
The present disclosure provides antigen-binding proteins, such as fully human antibodies, that specifically bind the spike (S) protein of the SARS-CoV-2 coronavirus and uses thereof.
Heyue Zhou, Xia Cao, Lucy Lu, Ying Yan, Yanliang Zhang, Henry Hongjun Ji, Robert Allen
Filed: 5 May 21
Utility
Oncolytic Herpes Simplex Viruses (HSV) Expressing Immunomodulatory Fusion Proteins
9 Nov 23
Recombinant oncolytic viruses that produce and secrete novel immunomodulatory fusion proteins are described.
Robert ALLEN, Colin POWERS, Gunnar KAUFMANN, Joe CONNER
Filed: 25 Jun 21
Utility
Fluid Delivery Apparatus with Microneedles
2 Nov 23
Disclosed herein are devices and methods for delivering a fluidic composition across a dermal barrier of a subject, e.g., into the lymphatic vasculature of the subject.
Russell Frederick Ross
Filed: 2 Dec 20
Utility
Treating Pulmonary Inflammatory Disease by Neural Ablation
28 Sep 23
There is disclosed a method for treating pulmonary inflammatory disease by neural ablation methods.
Alexis G. Nahama
Filed: 10 Aug 21
Utility
Administration of Resiniferatoxin For Treatment of Bladder Pain or Bladder Cancer
31 Aug 23
Disclosed herein are methods of administering resiniferatoxin (RTX) intravesically for treatment of bladder pain, and compositions for use in such methods.
Alexis Nahama, Henry Hongjun Ji
Filed: 18 Jun 21
Utility
ANTI-PD1 Antibodies and Uses Thereof
27 Jul 23
The present disclosure provides PD-1 binding proteins, particularly anti-PD-1 antibodies, or antigen-binding portions thereof, that specifically bind PD-1 and uses thereof.
Heyue ZHOU, Priscilla TANG, Damien BRESSON, Barbara SWANSON, Alok SINGH, Lisa KERWIN
Filed: 25 Jun 21
Utility
Pulmonary Administration of ACE2 Polypeptides
25 May 23
The present disclosure provides methods for treating a subject having a coronavirus infection by administering a composition that includes a sACE2 polypeptide to the lungs of a subject infected with a coronavirus.
Yanwen Fu, Yanliang Zhang, Heyue Zhou, Namir Shaabani, Reyna Lim, Yan Li, Chin-I Pai
Filed: 20 Apr 21
Utility
Application Device for a Fluid Delivery Apparatus and Method of Use
18 May 23
An application device for a fluid delivery includes a housing having a bore extending from a bottom of the housing.
Russell F. Ross, Luke Hagan, Aaron Peck, Alyson Yamada, Pratap Ganapathy
Filed: 19 Jan 23
Utility
Engineered Antibodies That Bind LAG3
11 May 23
The present disclosure provides fully human anti-LAG3 IgG class antibodies engineered to have amino acid sequence in their heavy chain variable region and/or light chain variable region to improve antigen binding, cell binding, T cell activation and cytokine release capabilities.
Damien Bresson, Min Soo Kim, Heyue Zhou, John Dixon Gray, Barbara A. Swanson, Alok Singh, Lisa Diane Kerwin
Filed: 1 Apr 21
Utility
Treating Pulmonary Inflammatory Disease Associated With Covid-19 By Administering Resiniferatoxin
11 May 23
There is disclosed a method for treating pulmonary inflammatory disease comprising administering an effective amount of resiniferatoxin (RTX) by an epidural, peri-ganglionic or intra-ganglionic administration.
Alexis Nahama, Henry Hongjun Ji, Irving H. Zucker, Hanjun Wang
Filed: 12 Mar 21
Utility
Device for Delivery of Rheumatoid Arthritis Medication
4 May 23
Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier.
Russell Frederick Ross
Filed: 29 Dec 22
Utility
Innate Immunity Killer Cells Targeting PSMA Positive Tumor Cells
30 Mar 23
The present disclosure provides an innate immunity cell such as a gamma delta T (gdT) cell, Natural Killer (NK) cell, or macrophage having 2-[3-(1,3-dicarboxypropyl)ureido] pentanedioic acid (DUPA) chemically conjugated to the cell surface.
Yanwen Fu, Reyna Lim, Daniel Lee, Matthew Buschman, Tong Zhu, Alisher B. Khasanov
Filed: 5 Mar 21
Utility
Natural Killer Cells for Treatment of Coronavirus Infection
9 Mar 23
The present disclosure provides a method for treating a subject having a coronavirus infection comprising administering to the subject at least one dose of a population of natural killer (NK) cells in an amount effective to reduce the coronavirus infection in the subject.
Henry Hongjun Ji
Filed: 27 Jan 21
Utility
Dimeric Antigen Receptors (DAR) That Bind CD20
2 Mar 23
The present disclosure provides dimeric antigen receptors (DAR) constructs that bind a CD20 target antigen, where the DAR construct comprises a heavy chain binding region on one polypeptide chain and a light chain binding region on a separate polypeptide chain.
Henry Hongjun Ji, Wenzhong Guo, Yanliang Zhang, Bei Bei Ding, Gunnar F. Kaufmann
Filed: 16 Aug 22
Utility
Method of Treating Cancer by Administration of an ANTI-PD-1 or ANTI-PD-L1 Therapeutic Agent Via a Lymphatic Devliery Device
5 Jan 23
Methods, devices and systems for delivery of an anti-PD-1 or an anti-PD-L1 therapeutic agent to the lymphatic system for treating cancer in a patient are described.
Russell Frederick Ross
Filed: 4 Dec 20
Utility
Formulation of Resiniferatoxin
24 Nov 22
Disclosed herein are safer formulations of resiniferatoxin (RTX) for intrathecal, intraganglionic intraarticular and pericardial administration.
Bryan Jones, Alexis G. Nahama
Filed: 5 Jan 22
Utility
Heterodimeric Antibodies That Bind to CD38 and CD3
17 Nov 22
The present disclosure provides heterodimeric antibodies that bind to two different target antigens at the same time.
Xiao He, Yanliang Zhang, Yun Wei Lai, Gunnar F. Kaufmann, Barbara A. Swanson, Lisa Diane Kerwin, Susan M. Richards
Filed: 30 Jun 20
Utility
Fluid Delivery Apparatus Having a Controller Assembly and Method of Use
10 Nov 22
A method for administering a medicament suitable for treating a migraine or cluster headache to a patient in need thereof includes placing a mounting surface of a fluid delivery apparatus with the medicament in contact with at least a portion of the skin of said patient.
Russell F. Ross, Andrew T. Baker, Luke Hagan
Filed: 5 May 22