83 patents
Page 2 of 5
Utility
Transdermal Drug Delivery Apparatus and Methods
20 Oct 22
A transdermal drug delivery apparatus includes a housing for being fastened to a user, a microneedle assembly for being engaged against the skin of the user, a first force provider for providing a first force for forcing the microneedle assembly outwardly from the housing and against the skin, a reservoir movably carried by the housing for containing the fluid and for being in fluid communication with the microneedle assembly, and a second force provider for providing a second force for causing at least some of the fluid to flow from the reservoir to the microneedle assembly after the reservoir has moved into fluid communication with the microneedle assembly.
Andrew T. Baker, Russell F. Ross, Elizabeth Deibler Gadsby, Luke Hagan
Filed: 28 Dec 21
Utility
Activatable Multi-Specific Antigen Binding Protein Complexes
13 Oct 22
The present disclosure provides several embodiments of multi-specific antigen binding protein complexes.
Yanliang Zhang, Gunnar F. Kaufmann, Xiao He, Yun Wei Lai
Filed: 10 Apr 20
Utility
Dimeric Antigen Receptors (DAR) that Bind BCMA
11 Aug 22
The present disclosure provides dimeric antigen receptors (DAR) constructs that bind a BCMA target antigen, where the DAR construct comprises a heavy chain binding region on one polypeptide chain and a light chain binding region on a separate polypeptide chain.
Henry Hongjun Ji, Wenzhong Guo, Yanliang Zhang, Bei Bei Ding, Gunnar F. Kaufmann
Filed: 3 Mar 22
Utility
Antigen Binding Proteins that Bind PD-1
4 Aug 22
There is disclosed compositions and methods relating to or derived from anti-PD-1 antibodies.
Heyue Zhou, Barbara A. Swanson, John Dixon Gray, Gunnar F. Kaufmann, Edwige Gros
Filed: 17 Dec 21
Utility
Cannabidiol Pharmaceutical Compositions
16 Jun 22
Disclosed herein are aqueous pharmaceutical compositions comprising cannabidiol, method of making such compositions, and methods of treatment using such pharmaceutical compositions.
Hui Xie, Hua Wang, Henry Hongjun Ji, Jonathan D. Wang
Filed: 3 Apr 20
Utility
Improved Process for Dna Integration Using Rna-guided Endonucleases
2 Jun 22
There is disclosed an improved, safer and commercially efficient process for developing genetically engineered cells.
Beibei Ding, Wenzhong Guo, Yanliang Zhang
Filed: 27 Feb 20
Utility
Engineered Variant Antibodies that Bind CD38
12 May 22
The present disclosure provides anti-CD38 antigen-binding proteins such as fully human anti-CD38 IgG class antibodies each having an altered amino acid sequence in their heavy chain variable region and/or light chain variable region compared to their wild type parent antibody.
Xia Cao, Heyue Zhou, John Dixon Gray, Barbara A. Swanson
Filed: 27 Mar 20
Utility
Improved Process for Integration of Dna Constructs Using Rna-guided Endonucleases
12 May 22
There is disclosed an improved, safer and commercially efficient process for developing genetically engineered cells.
Beibei Ding, Wenzhong Guo, Yanliang Zhang
Filed: 11 Mar 20
Utility
Chemically-Locked Bispecific Antibodies
12 May 22
Yanwen Fu, Gunnar F. Kaufmann, James T. Patterson
Filed: 26 Jan 22
Utility
CD38 Antibody Drug Conjugate
21 Apr 22
There is disclosed an antibody drug conjugate (ADC) having an IgG antibody that binds to a CD38 target conjugated at a Cys site in the hinge region of an IgG antibody.
Tong Zhu, Alisher Khasanov, Gang Chen, Katherine Fells, Heyue Zhou, John Dixon Gray
Filed: 3 Nov 21
Utility
Method for Treating Osteoarthritis Pain by Administering Resiniferatoxin
31 Mar 22
Disclosed herein are methods of administering resiniferatoxin (RTX) for treatment of osteoarthritis (OA) pain, and compositions for use in such methods.
Alexis Nahama, Henry Hongjun Ji
Filed: 21 Jan 20
Utility
Method for Administering a Medicament Suitable for Treating a Migraine or Cluster Headache
17 Mar 22
A method for administering a medicament suitable for treating a migraine or cluster headache to a patient in need thereof includes placing a mounting surface of a fluid delivery apparatus with the medicament in contact with at least a portion of the skin of said patient.
Russell F. Ross, Andrew T. Baker, Luke Hagan
Filed: 30 Nov 21
Utility
Nanopatterned Medical Device with Enhanced Cellular Interaction
10 Feb 22
A medical device for delivering a drug compound through a stratum corneum includes a support having an aperture, an array of microneedles extending outwardly from the support, a plurality of nanostructures associated with each microneedle, and a reservoir wherein the drug compound is retained.
Russell Frederick Ross
Filed: 19 Oct 21
Utility
Microneedle Array Assembly, Drug Delivery Device and Method for Administering Liquid Across a Broad Area at Low Pressure
10 Feb 22
A uniformity control membrane can be securely engaged against an upstream side of a microneedle array and configured so that resistance to flow through the uniformity control membrane is substantially greater than the resistance to flow through the microneedle array.
Andrew T. Baker, Russell F. Ross, Elizabeth Deibler Gadsby, Luke Hagan
Filed: 25 Oct 21
Utility
Fully Human Antibodies That Bind to Vascular Endothelial Growth Factor Receptor (VEGFR2)
27 Jan 22
There is disclosed compositions and methods relating to anti-VEGFR2 antibodies.
Randy Gastwirt, Heyue Zhou, John Dixon Gray, Guodi Lu
Filed: 29 Jul 21
Utility
Antibody Therapeutics That Bind CD137
27 Jan 22
There is disclosed compositions and methods relating to or derived from anti-CD137 antibodies.
John Dixon GRAY, Heyue ZHOU
Filed: 12 Oct 21
Utility
Transdermal Delivery of High Viscosity Bioactive Agents
13 Jan 22
A device and method for delivery of a bioactive agent across a dermal barrier of a subject.
Russell F. Ross
Filed: 23 Aug 21
Utility
Antibody Therapeutics that Bind CTLA4
6 Jan 22
There is disclosed compositions and methods relating to or derived from anti-CTLA4 antibodies.
John Dixon Gray, Heyue Zhou
Filed: 22 Sep 21
Utility
Antigen Binding Proteins that Bind c-Met
6 Jan 22
There is disclosed compositions and methods relating to or derived from anti-c-Met antibodies.
Barbara A. Swanson, Heyue Zhou, Yan-Liang Zhang, Randy Gastwirt, John Dixon Gray
Filed: 22 Sep 21
Utility
Implantable Devices for Delivery of Bioactive Agents
30 Dec 21
An implantable delivery device and method for utilizing the device to delivery a bioactive agent to a subject in need thereof is described.
Jeremy Ollerenshaw, Emily Reichart, Russell F. Ross
Filed: 2 Aug 21