151 patents
Page 4 of 8
Utility
Variant Antibodies That Bind OX40
23 Dec 21
The present disclosure provides variant anti-OX40 antibodies that mimic the activity of OX4OL by behaving as an agonist against receptor OX40 to enhance T cell clonal expansion and differentiation.
Min Soo Kim
Filed: 23 Aug 21
Utility
Antigen Binding Proteins that Bind BCMA
16 Dec 21
The present disclosure provides BCMA binding proteins, particularly anti-BCMA antibodies, or antigen-binding portions thereof, that specifically bind BCMA and uses thereof.
Heyue Zhou, Xia Cao
Filed: 25 Aug 21
Utility
CD38 antibody drug conjugate
7 Dec 21
There is disclosed an antibody drug conjugate (ADC) having an IgG antibody that binds to a CD38 target conjugated at a Cys site in the hinge region of an IgG antibody.
Tong Zhu, Alisher Khasanov, Gang Chen, Katherine Fells, Heyue Zhou, John Dixon Gray
Filed: 20 Jun 18
Utility
Microneedle array assembly, drug delivery device and method for administering liquid across a broad area at low pressure
23 Nov 21
A uniformity control membrane can be securely engaged against an upstream side of a microneedle array and configured so that resistance to flow through the uniformity control membrane is substantially greater than the resistance to flow through the microneedle array.
Andrew T. Baker, Russell F. Ross, Elizabeth Deibler Gadsby, Luke Hagan
Filed: 17 Apr 17
Utility
Nanopatterned medical device with enhanced cellular interaction
23 Nov 21
A medical device for delivering a drug compound through a stratum corneum includes a support having an aperture, an array of microneedles extending outwardly from the support, a plurality of nanostructures associated with each microneedle, and a reservoir wherein the drug compound is retained.
Russell Frederick Ross
Filed: 22 Mar 19
Utility
Antibody therapeutics that bind CD137
23 Nov 21
There is disclosed compositions and methods relating to or derived from anti-CD137 antibodies.
John Dixon Gray, Heyue Zhou
Filed: 8 Feb 19
Utility
Anti-KRAS binding proteins
16 Nov 21
The present disclosure provides anti-KRAS antibodies, and antigen-binding fragments thereof.
Heyue Zhou, Min Soo Kim
Filed: 10 Apr 19
Utility
Antigen Binding Proteins That Bind PD-L1
28 Oct 21
There is disclosed compositions and methods relating to or derived from anti-PD-L1 antibodies.
Heyue Zhou, Randy Gastwirt, Barbara A. Swanson, John Dixon Gray, Gunnar F. Kaufmann
Filed: 3 May 21
Utility
Antibody therapeutics that bind CTLA4
26 Oct 21
There is disclosed compositions and methods relating to or derived from anti-CTLA4 antibodies.
John Dixon Gray, Heyue Zhou
Filed: 8 Jan 19
Utility
Antigen binding proteins that bind c-Met
26 Oct 21
There is disclosed compositions and methods relating to or derived from anti-c-Met antibodies.
Barbara A. Swanson, Heyue Zhou, Yan-Liang Zhang, Randy Gastwirt, John Dixon Gray
Filed: 25 Jun 19
Utility
Variant antibodies that bind OX40
12 Oct 21
The present disclosure provides variant anti-OX40 antibodies that mimic the activity of OX40L by behaving as an agonist against receptor OX40 to enhance T cell clonal expansion and differentiation.
Min Soo Kim
Filed: 6 Dec 18
Utility
Medical devices for delivery of siRNA
5 Oct 21
Disclosed are medical devices that incorporate siRNA.
Russell Frederick Ross
Filed: 20 Jul 18
Utility
Methods for Treating Parkinson?s Disease by Administering Resiniferatoxin
30 Sep 21
There is disclosed a method for treating Parkinson's Disease (PD) comprising administering an effective amount of Resiniferatoxin (RTX) by an intrathecal or intracisternal administration.
Alexis Nahama, Henry Hongjun Ji
Filed: 11 Jun 21
Utility
Transdermal delivery of high viscosity bioactive agents
28 Sep 21
A device and method for delivering a high viscosity composition is described.
Russell F. Ross
Filed: 10 Jan 19
Utility
Implantable devices for delivery of bioactive agents
7 Sep 21
An implantable delivery device and method for utilizing the device to delivery a bioactive agent to a subject in need thereof is described.
Jeremy Ollerenshaw, Emily Reichart, Russell F. Ross
Filed: 16 Oct 12
Utility
Fully human antibodies that bind to vascular endothelial growth factor receptor 2 (VEGFR2)
7 Sep 21
There is disclosed compositions and methods relating to anti-VEGFR2 antibodies.
Randy Gastwirt, Heyue Zhou, John Dixon Gray, Guodi Lu
Filed: 7 Apr 15
Utility
Antibody Drug Conjugates Having Derivatives of Amatoxin As The Drug
26 Aug 21
There is disclosed derivatives of amanitin conjugated to a targeting antibody to form an ADC (antibody drug conjugate).
Tong Zhu, Hong Zhang, Alisher B. Khasanov, Gang Chen
Filed: 26 Apr 21
Utility
Method for increasing permeability of a cellular layer of epithelial cells
10 Aug 21
A method for increasing permeability of a cellular layer of epithelial cells includes contacting the cellular layer with a nanostructured surface including a plurality of first nanostructures arranged thereon and projecting outward therefrom.
Russell Frederick Ross
Filed: 24 May 19
Utility
Drug Delivery Methods Targeting the Lymphatic System
29 Jul 21
Disclosed herein is a method for administering a therapeutic agent to multiple regions of the lymphatic system of a patient.
RUSSELL FREDERICK ROSS
Filed: 30 May 19
Utility
Compositions and Methods Comprising an Anti-CD47 Antibody in Combination with a Tumor Targeting Antibody
22 Jul 21
The present disclosure provides compositions and methods comprising a first antibody comprising a fully human anti-CD47 antibody and a second antibody comprising an Fc portion that binds an Fcγ receptor on an effector cell.
Damien Bresson, Heyue Zhou, Christophe Pedros
Filed: 4 Dec 20