151 patents
Page 2 of 8
Utility
Natural Killer Cells for Treatment of Coronavirus Infection
9 Mar 23
The present disclosure provides a method for treating a subject having a coronavirus infection comprising administering to the subject at least one dose of a population of natural killer (NK) cells in an amount effective to reduce the coronavirus infection in the subject.
Henry Hongjun Ji
Filed: 27 Jan 21
Utility
Dimeric Antigen Receptors (DAR) That Bind CD20
2 Mar 23
The present disclosure provides dimeric antigen receptors (DAR) constructs that bind a CD20 target antigen, where the DAR construct comprises a heavy chain binding region on one polypeptide chain and a light chain binding region on a separate polypeptide chain.
Henry Hongjun Ji, Wenzhong Guo, Yanliang Zhang, Bei Bei Ding, Gunnar F. Kaufmann
Filed: 16 Aug 22
Utility
Application device for a fluid delivery apparatus and method of use
14 Feb 23
An application device for a fluid delivery includes a housing having a bore extending from a bottom of the housing.
Russell F. Ross, Luke Hagan, Aaron Peck, Alyson Yamada, Pratap Ganapathy
Filed: 5 Dec 17
Utility
Device for delivery of rheumatoid arthritis medication
31 Jan 23
Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier.
Russell Frederick Ross
Filed: 9 Jun 20
Utility
Fluid delivery apparatus and method of assembly
24 Jan 23
A fluid delivery apparatus includes a collet assembly having an upper and lower wall attached at a central portion of the collet.
Russell F. Ross, Andrew T. Baker, Elizabeth D. Gadsby, Luke Hagan, Aaron Peck, Alyson Yamada, Pratap Ganapathy
Filed: 25 Feb 20
Utility
Method of Treating Cancer by Administration of an ANTI-PD-1 or ANTI-PD-L1 Therapeutic Agent Via a Lymphatic Devliery Device
5 Jan 23
Methods, devices and systems for delivery of an anti-PD-1 or an anti-PD-L1 therapeutic agent to the lymphatic system for treating cancer in a patient are described.
Russell Frederick Ross
Filed: 4 Dec 20
Utility
Formulation of Resiniferatoxin
24 Nov 22
Disclosed herein are safer formulations of resiniferatoxin (RTX) for intrathecal, intraganglionic intraarticular and pericardial administration.
Bryan Jones, Alexis G. Nahama
Filed: 5 Jan 22
Utility
Heterodimeric Antibodies That Bind to CD38 and CD3
17 Nov 22
The present disclosure provides heterodimeric antibodies that bind to two different target antigens at the same time.
Xiao He, Yanliang Zhang, Yun Wei Lai, Gunnar F. Kaufmann, Barbara A. Swanson, Lisa Diane Kerwin, Susan M. Richards
Filed: 30 Jun 20
Utility
Fluid Delivery Apparatus Having a Controller Assembly and Method of Use
10 Nov 22
A method for administering a medicament suitable for treating a migraine or cluster headache to a patient in need thereof includes placing a mounting surface of a fluid delivery apparatus with the medicament in contact with at least a portion of the skin of said patient.
Russell F. Ross, Andrew T. Baker, Luke Hagan
Filed: 5 May 22
Utility
Transdermal Drug Delivery Apparatus and Methods
20 Oct 22
A transdermal drug delivery apparatus includes a housing for being fastened to a user, a microneedle assembly for being engaged against the skin of the user, a first force provider for providing a first force for forcing the microneedle assembly outwardly from the housing and against the skin, a reservoir movably carried by the housing for containing the fluid and for being in fluid communication with the microneedle assembly, and a second force provider for providing a second force for causing at least some of the fluid to flow from the reservoir to the microneedle assembly after the reservoir has moved into fluid communication with the microneedle assembly.
Andrew T. Baker, Russell F. Ross, Elizabeth Deibler Gadsby, Luke Hagan
Filed: 28 Dec 21
Utility
Activatable Multi-Specific Antigen Binding Protein Complexes
13 Oct 22
The present disclosure provides several embodiments of multi-specific antigen binding protein complexes.
Yanliang Zhang, Gunnar F. Kaufmann, Xiao He, Yun Wei Lai
Filed: 10 Apr 20
Utility
Dimeric Antigen Receptors (DAR) that Bind BCMA
11 Aug 22
The present disclosure provides dimeric antigen receptors (DAR) constructs that bind a BCMA target antigen, where the DAR construct comprises a heavy chain binding region on one polypeptide chain and a light chain binding region on a separate polypeptide chain.
Henry Hongjun Ji, Wenzhong Guo, Yanliang Zhang, Bei Bei Ding, Gunnar F. Kaufmann
Filed: 3 Mar 22
Utility
Antigen Binding Proteins that Bind PD-1
4 Aug 22
There is disclosed compositions and methods relating to or derived from anti-PD-1 antibodies.
Heyue Zhou, Barbara A. Swanson, John Dixon Gray, Gunnar F. Kaufmann, Edwige Gros
Filed: 17 Dec 21
Utility
Cannabidiol Pharmaceutical Compositions
16 Jun 22
Disclosed herein are aqueous pharmaceutical compositions comprising cannabidiol, method of making such compositions, and methods of treatment using such pharmaceutical compositions.
Hui Xie, Hua Wang, Henry Hongjun Ji, Jonathan D. Wang
Filed: 3 Apr 20
Utility
Improved Process for Dna Integration Using Rna-guided Endonucleases
2 Jun 22
There is disclosed an improved, safer and commercially efficient process for developing genetically engineered cells.
Beibei Ding, Wenzhong Guo, Yanliang Zhang
Filed: 27 Feb 20
Utility
Fluid delivery apparatus having a controller assembly and method of use
31 May 22
A controller assembly of a fluid delivery apparatus includes a body component and a plunger component slidably coupled to the body component.
Russell F. Ross, Andrew T. Baker, Luke Hagan
Filed: 5 Dec 17
Utility
Engineered Variant Antibodies that Bind CD38
12 May 22
The present disclosure provides anti-CD38 antigen-binding proteins such as fully human anti-CD38 IgG class antibodies each having an altered amino acid sequence in their heavy chain variable region and/or light chain variable region compared to their wild type parent antibody.
Xia Cao, Heyue Zhou, John Dixon Gray, Barbara A. Swanson
Filed: 27 Mar 20
Utility
Chemically-Locked Bispecific Antibodies
12 May 22
Yanwen Fu, Gunnar F. Kaufmann, James T. Patterson
Filed: 26 Jan 22
Utility
Improved Process for Integration of Dna Constructs Using Rna-guided Endonucleases
12 May 22
There is disclosed an improved, safer and commercially efficient process for developing genetically engineered cells.
Beibei Ding, Wenzhong Guo, Yanliang Zhang
Filed: 11 Mar 20
Utility
Antigen binding proteins that bind WISP1
3 May 22
There is disclosed compositions and methods relating to or derived from anti-WISP1 antibodies.
Heyue Zhou, Gunnar F. Kaufmann
Filed: 3 Apr 19