Prudential Investment Portfolios 12 N-CSR Certified annual shareholder report (management investment company)

Certification Pursuant to 18 U.S.C. Section 1350

As Adopted Pursuant to

Section 906 of the Sarbanes-Oxley Act of 2002

Name of Issuer:             Prudential Investment Portfolios 12

In connection with the Report on Form N-CSR of the above-named issuer that is accompanied by this certification, the undersigned hereby certifies, to his or her knowledge, that:

1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Issuer.

May 23, 2011	/s/ Judy A. Rice
	Judy A. Rice
	President and Principal Executive Officer
May 23, 2011	/s/ Grace C. Torres
	Grace C. Torres
	Treasurer and Principal Financial Officer