SPDR(R) S&P(R) Biotech ETF

Fund Profile

Fund profile

Tickers

XBI

Fund manager

SPDR S&P Regional Banking ETF

Total assets

$6.82 bn

Liabilities

$449.86 mm

Net assets

$6.37 bn

Number of holdings

145.00

XBI stock data

1M 3M 6M 1Y

145 Holdings

As of Dec 2024

Security	$Holding	Balance	% of Fund	Category	Position	Country
State Street Navigator Securities Lending Portfolio II	447.87 mm	447.87 mm shares	7.03	Short-term investment vehicle	Long	USA
NBIX Neurocrine Biosciences, Inc.	162.79 mm	1.19 mm shares	2.56	Common equity	Long	USA
ABBV AbbVie Inc.	155.83 mm	876.91 k shares	2.45	Common equity	Long	USA
GILD Gilead Sciences, Inc.	152.90 mm	1.66 mm shares	2.40	Common equity	Long	USA
BMRN BioMarin Pharmaceutical Inc.	152.35 mm	2.32 mm shares	2.39	Common equity	Long	USA
UTHR United Therapeutics Corporation	148.97 mm	422.19 k shares	2.34	Common equity	Long	USA
BIIB Biogen Inc.	148.50 mm	971.10 k shares	2.33	Common equity	Long	USA
MRNA Moderna, Inc.	148.35 mm	3.57 mm shares	2.33	Common equity	Long	USA
SRPT Sarepta Therapeutics, Inc.	148.28 mm	1.22 mm shares	2.33	Common equity	Long	USA
AMGN Amgen Inc.	145.77 mm	559.28 k shares	2.29	Common equity	Long	USA
INCY Incyte Corporation	145.70 mm	2.11 mm shares	2.29	Common equity	Long	USA
NTRA Natera, Inc.	144.84 mm	914.98 k shares	2.27	Common equity	Long	USA
INSM Insmed Incorporated	142.28 mm	2.06 mm shares	2.23	Common equity	Long	USA
ALNY Alnylam Pharmaceuticals, Inc.	141.58 mm	601.66 k shares	2.22	Common equity	Long	USA
REGN Regeneron Pharmaceuticals, Inc.	140.91 mm	197.82 k shares	2.21	Common equity	Long	USA
PCVX Vaxcyte, Inc.	137.48 mm	1.68 mm shares	2.16	Common equity	Long	USA
EXAS Exact Sciences Corporation	136.04 mm	2.42 mm shares	2.14	Common equity	Long	USA
VRTX Vertex Pharmaceuticals Incorporated	131.49 mm	326.51 k shares	2.06	Common equity	Long	USA
VKTX Viking Therapeutics, Inc.	124.29 mm	3.09 mm shares	1.95	Common equity	Long	USA
HALO Halozyme Therapeutics, Inc.	117.90 mm	2.47 mm shares	1.85	Common equity	Long	USA
MDGL Madrigal Pharmaceuticals, Inc.	116.44 mm	377.34 k shares	1.83	Common equity	Long	USA
TGTX TG Therapeutics, Inc.	113.63 mm	3.78 mm shares	1.78	Common equity	Long	USA
ADMA ADMA Biologics, Inc.	100.24 mm	5.84 mm shares	1.57	Common equity	Long	USA
Roivant Sciences Ltd	96.03 mm	8.12 mm shares	1.51	Common equity	Long	Bermuda
IONS Ionis Pharmaceuticals, Inc.	94.51 mm	2.70 mm shares	1.48	Common equity	Long	USA
CYTK Cytokinetics, Incorporated	88.54 mm	1.88 mm shares	1.39	Common equity	Long	USA
BPMC Blueprint Medicines Corporation	88.31 mm	1.01 mm shares	1.39	Common equity	Long	USA
APLS Apellis Pharmaceuticals, Inc.	87.77 mm	2.75 mm shares	1.38	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	86.09 mm	1.97 mm shares	1.35	Common equity	Long	USA
EXEL Exelixis, Inc.	80.35 mm	2.41 mm shares	1.26	Common equity	Long	USA
BBIO BridgeBio Pharma, Inc.	78.22 mm	2.85 mm shares	1.23	Common equity	Long	USA
CRISPR Therapeutics AG	74.34 mm	1.89 mm shares	1.17	Common equity	Long	Switzerland
Alkermes PLC	68.66 mm	2.39 mm shares	1.08	Common equity	Long	Ireland
SMMT Summit Therapeutics Inc.	63.36 mm	3.55 mm shares	0.99	Common equity	Long	USA
ACLX Arcellx, Inc.	62.05 mm	809.12 k shares	0.97	Common equity	Long	USA
RNA Avidity Biosciences, Inc.	58.62 mm	2.02 mm shares	0.92	Common equity	Long	USA
Biohaven Ltd	57.54 mm	1.54 mm shares	0.90	Common equity	Long	Virgin Islands (British)
NUVL Nuvalent, Inc.	52.86 mm	675.21 k shares	0.83	Common equity	Long	USA
SWTX SpringWorks Therapeutics, Inc.	50.60 mm	1.40 mm shares	0.79	Common equity	Long	USA
TWST Twist Bioscience Corporation	49.40 mm	1.06 mm shares	0.78	Common equity	Long	USA
RARE Ultragenyx Pharmaceutical Inc.	48.54 mm	1.15 mm shares	0.76	Common equity	Long	USA
KRYS Krystal Biotech, Inc.	48.54 mm	309.85 k shares	0.76	Common equity	Long	USA
GERN Geron Corporation	48.53 mm	13.71 mm shares	0.76	Common equity	Long	USA
CRNX Crinetics Pharmaceuticals, Inc.	47.32 mm	925.53 k shares	0.74	Common equity	Long	USA
IOVA Iovance Biotherapeutics, Inc.	46.71 mm	6.31 mm shares	0.73	Common equity	Long	USA
RXRX Recursion Pharmaceuticals, Inc.	45.85 mm	6.78 mm shares	0.72	Common equity	Long	USA
DYN Dyne Therapeutics, Inc.	44.95 mm	1.91 mm shares	0.71	Common equity	Long	USA
CLDX Celldex Therapeutics, Inc.	43.88 mm	1.74 mm shares	0.69	Common equity	Long	USA
VERA Vera Therapeutics, Inc.	42.24 mm	998.82 k shares	0.66	Common equity	Long	USA
PTGX Protagonist Therapeutics, Inc.	41.97 mm	1.09 mm shares	0.66	Common equity	Long	USA
VCYT Veracyte, Inc.	40.76 mm	1.03 mm shares	0.64	Common equity	Long	USA
PTCT PTC Therapeutics, Inc.	40.12 mm	888.84 k shares	0.63	Common equity	Long	USA
SRRK Scholar Rock Holding Corporation	38.44 mm	889.40 k shares	0.60	Common equity	Long	USA
VRDN Viridian Therapeutics, Inc.	37.77 mm	1.97 mm shares	0.59	Common equity	Long	USA
DVAX Dynavax Technologies Corporation	36.25 mm	2.84 mm shares	0.57	Common equity	Long	USA
FOLD Amicus Therapeutics, Inc.	35.77 mm	3.80 mm shares	0.56	Common equity	Long	USA
TVTX Travere Therapeutics, Inc.	35.01 mm	2.01 mm shares	0.55	Common equity	Long	USA
IDYA IDEAYA Biosciences, Inc.	34.61 mm	1.35 mm shares	0.54	Common equity	Long	USA
SLNO Soleno Therapeutics, Inc.	34.04 mm	757.25 k shares	0.53	Common equity	Long	USA
NTLA Intellia Therapeutics, Inc.	33.90 mm	2.91 mm shares	0.53	Common equity	Long	USA
ARQT Arcutis Biotherapeutics, Inc.	33.38 mm	2.40 mm shares	0.52	Common equity	Long	USA
IMVT Immunovant, Inc.	32.91 mm	1.33 mm shares	0.52	Common equity	Long	USA
NVAX Novavax, Inc.	32.81 mm	4.08 mm shares	0.52	Common equity	Long	USA
DNLI Denali Therapeutics Inc.	32.80 mm	1.61 mm shares	0.52	Common equity	Long	USA
RYTM Rhythm Pharmaceuticals, Inc.	32.14 mm	574.05 k shares	0.50	Common equity	Long	USA
JANX Janux Therapeutics, Inc.	31.82 mm	594.23 k shares	0.50	Common equity	Long	USA
ACAD ACADIA Pharmaceuticals Inc.	31.40 mm	1.71 mm shares	0.49	Common equity	Long	USA
BEAM Beam Therapeutics Inc.	31.38 mm	1.27 mm shares	0.49	Common equity	Long	USA
ARDX Ardelyx, Inc.	30.88 mm	6.09 mm shares	0.48	Common equity	Long	USA
APGE Apogee Therapeutics, Inc.	29.76 mm	656.87 k shares	0.47	Common equity	Long	USA
PRAX Praxis Precision Medicines, Inc.	29.47 mm	382.99 k shares	0.46	Common equity	Long	USA
CDNA CareDx, Inc	29.22 mm	1.36 mm shares	0.46	Common equity	Long	USA
ARWR Arrowhead Pharmaceuticals, Inc.	29.02 mm	1.54 mm shares	0.46	Common equity	Long	USA
CPRX Catalyst Pharmaceuticals, Inc.	27.84 mm	1.33 mm shares	0.44	Common equity	Long	USA
SNDX Syndax Pharmaceuticals, Inc.	26.83 mm	2.03 mm shares	0.42	Common equity	Long	USA
AGIO Agios Pharmaceuticals, Inc.	26.32 mm	800.88 k shares	0.41	Common equity	Long	USA
VCEL Vericel Corporation	26.07 mm	474.83 k shares	0.41	Common equity	Long	USA
KYMR Kymera Therapeutics, Inc.	26.07 mm	647.92 k shares	0.41	Common equity	Long	USA
MYGN Myriad Genetics, Inc.	25.94 mm	1.89 mm shares	0.41	Common equity	Long	USA
CGON CG Oncology, Inc. Common stock	25.72 mm	896.66 k shares	0.40	Common equity	Long	USA
NRIX Nurix Therapeutics, Inc.	24.93 mm	1.32 mm shares	0.39	Common equity	Long	USA
AKRO Akero Therapeutics, Inc.	23.01 mm	826.97 k shares	0.36	Common equity	Long	USA
DAWN Day One Biopharmaceuticals, Inc.	23.01 mm	1.82 mm shares	0.36	Common equity	Long	USA
MNKD MannKind Corporation	22.82 mm	3.55 mm shares	0.36	Common equity	Long	USA
RCKT Rocket Pharmaceuticals, Inc.	22.37 mm	1.78 mm shares	0.35	Common equity	Long	USA
MIRM Mirum Pharmaceuticals, Inc.	21.27 mm	514.37 k shares	0.33	Common equity	Long	USA
SYRE Spyre Therapeutics, Inc.	20.35 mm	874.12 k shares	0.32	Common equity	Long	USA
BCRX BioCryst Pharmaceuticals, Inc.	20.12 mm	2.67 mm shares	0.32	Common equity	Long	USA
IRON Disc Medicine, Inc.	20.04 mm	316.05 k shares	0.31	Common equity	Long	USA
CAPR Capricor Therapeutics, Inc.	19.86 mm	1.44 mm shares	0.31	Common equity	Long	USA
SPRY ARS Pharmaceuticals, Inc.	16.87 mm	1.60 mm shares	0.26	Common equity	Long	USA
IBRX ImmunityBio, Inc.	16.04 mm	6.26 mm shares	0.25	Common equity	Long	USA
EBS Emergent BioSolutions Inc.	15.76 mm	1.65 mm shares	0.25	Common equity	Long	USA
CDMO Avid Bioservices, Inc.	14.77 mm	1.20 mm shares	0.23	Common equity	Long	USA
KURA Kura Oncology, Inc.	14.45 mm	1.66 mm shares	0.23	Common equity	Long	USA
COGT Cogent Biosciences, Inc.	14.29 mm	1.83 mm shares	0.22	Common equity	Long	USA
XNCR Xencor, Inc.	13.61 mm	592.05 k shares	0.21	Common equity	Long	USA
HUMA Humacyte, Inc.	13.29 mm	2.63 mm shares	0.21	Common equity	Long	USA
RCUS Arcus Biosciences, Inc.	13.18 mm	884.87 k shares	0.21	Common equity	Long	USA
ALT Altimmune, Inc.	12.96 mm	1.80 mm shares	0.20	Common equity	Long	USA
ANNX Annexon, Inc.	12.76 mm	2.49 mm shares	0.20	Common equity	Long	USA
CGEM Cullinan Oncology, Inc.	12.44 mm	1.02 mm shares	0.20	Common equity	Long	USA
Prothena Corp PLC	12.25 mm	884.76 k shares	0.19	Common equity	Long	Ireland
IRWD Ironwood Pharmaceuticals, Inc.	11.95 mm	2.70 mm shares	0.19	Common equity	Long	USA
RLAY Relay Therapeutics, Inc.	11.71 mm	2.84 mm shares	0.18	Common equity	Long	USA
GRAL GRAIL, Inc.	11.37 mm	636.84 k shares	0.18	Common equity	Long	USA
Arcturus Therapeutics Holdings, Inc.	11.13 mm	656.03 k shares	0.17	Common equity	Long	USA
ANAB AnaptysBio, Inc.	10.69 mm	807.47 k shares	0.17	Common equity	Long	USA
REPL Replimune Group, Inc.	10.66 mm	880.58 k shares	0.17	Common equity	Long	USA
VIR Vir Biotechnology, Inc.	10.09 mm	1.38 mm shares	0.16	Common equity	Long	USA
IMNM Immunome, Inc.	9.85 mm	927.10 k shares	0.15	Common equity	Long	USA
AVXL Anavex Life Sciences Corp.	9.13 mm	849.80 k shares	0.14	Common equity	Long	USA
ALLO Allogene Therapeutics, Inc.	8.91 mm	4.19 mm shares	0.14	Common equity	Long	USA
VERV Verve Therapeutics, Inc.	8.76 mm	1.55 mm shares	0.14	Common equity	Long	USA
STOK Stoke Therapeutics, Inc.	8.45 mm	765.79 k shares	0.13	Common equity	Long	USA
ArriVent Biopharma Inc	8.28 mm	310.97 k shares	0.13	Common equity	Long	USA
RGNX REGENXBIO Inc.	8.26 mm	1.07 mm shares	0.13	Common equity	Long	USA
KROS Keros Therapeutics, Inc.	8.26 mm	521.68 k shares	0.13	Common equity	Long	USA
ETNB 89bio, Inc.	7.90 mm	1.01 mm shares	0.12	Common equity	Long	USA
DNTH Dianthus Therapeutics, Inc.	7.07 mm	324.13 k shares	0.11	Common equity	Long	USA
TRML Tourmaline Bio, Inc.	6.90 mm	340.00 k shares	0.11	Common equity	Long	USA
ERAS Erasca, Inc.	6.00 mm	2.39 mm shares	0.09	Common equity	Long	USA
LENZ LENZ Therapeutics, Inc.	5.83 mm	201.87 k shares	0.09	Common equity	Long	USA
SANA Sana Biotechnology, Inc.	5.83 mm	3.58 mm shares	0.09	Common equity	Long	USA
MDXG MiMedx Group, Inc.	5.51 mm	572.42 k shares	0.09	Common equity	Long	USA
ABUS Arbutus Biopharma Corporation	5.47 mm	1.67 mm shares	0.09	Common equity	Long	Canada
OLMA Olema Pharmaceuticals, Inc.	5.41 mm	927.52 k shares	0.08	Common equity	Long	USA
CRGX CARGO Therapeutics, Inc. Common Stock	5.39 mm	373.76 k shares	0.08	Common equity	Long	USA
KalVista Pharmaceuticals Inc	5.25 mm	620.37 k shares	0.08	Common equity	Long	USA
SVRA Savara Inc.	5.14 mm	1.67 mm shares	0.08	Common equity	Long	USA
TSHA Taysha Gene Therapies, Inc.	4.97 mm	2.87 mm shares	0.08	Common equity	Long	USA
ORIC ORIC Pharmaceuticals, Inc.	4.72 mm	585.45 k shares	0.07	Common equity	Long	USA
CELC Celcuity Inc.	4.60 mm	351.66 k shares	0.07	Common equity	Long	USA
SGMO Sangamo Therapeutics, Inc.	4.08 mm	4.00 mm shares	0.06	Common equity	Long	USA
AKBA Akebia Therapeutics, Inc.	3.89 mm	2.05 mm shares	0.06	Common equity	Long	USA
ATXS Astria Therapeutics, Inc.	3.83 mm	428.00 k shares	0.06	Common equity	Long	USA
YMAB Y-mAbs Therapeutics, Inc.	3.68 mm	469.95 k shares	0.06	Common equity	Long	USA
State Street Institutional US Government Money Market Fund	3.62 mm	3.62 mm shares	0.06	Short-term investment vehicle	Long	USA
SCLX Scilex Holding Company	2.53 mm	5.94 mm shares	0.04	Common equity	Long	USA
GLUE Monte Rosa Therapeutics, Inc.	2.18 mm	314.50 k shares	0.03	Common equity	Long	USA
CONTRA INHIBRX INC	1.07 mm	1.65 mm shares	0.02	Equity derivative	N/A	USA
CONTRA MIRATI THERAPEU	958.69 k	1.37 mm shares	0.02	Equity derivative	N/A	USA
State Street Institutional US Government Money Market Fund	18.69 k	18.69 k shares	0.00	Short-term investment vehicle	Long	USA
OABI OmniAb, Inc.	0	161.96 k shares	0.00	Common equity	Long	USA
OABI OmniAb, Inc.	0	161.96 k shares	0.00	Common equity	Long	USA