230 patents
Page 6 of 12
Utility
Chromatographic Dimension Selection In Multidimensional Liquid Chromatography
30 Dec 21
A system capable of performing both single and multidimensional liquid chromatography includes a solvent delivery system, a sample injection system, a first dimension column path configured to perform a separation process in a first dimension, a second dimension column path configured to perform a separation process in a second dimension that is different than the first dimension, a valve system; and a sample injection system fluidically connected to the valve system.
Michael O. Fogwill
Filed: 28 Jun 21
Utility
Methods for Heat-assisted Enzyme Digestion
23 Dec 21
The present disclosure relates to a kit for sample preparation, the kit including a solid support surface with a polymer coating covering the solid support surface, wherein the polymer coating reduces undesired interactions between the sample and the solid support surface, a buffer comprising arginine and methionine, and a vessel for containing the solid support surface and the buffer.
Wenjing Li, Beatrice Muriithi, Anna Boardman, Matthew A. Lauber
Filed: 3 Sep 21
Utility
Parallel Insulated Chromatography Columns
23 Dec 21
The exemplary embodiments may provide a collective insulating sleeve for a plurality of chromatography columns or may provide separate insulating sleeve for each of the chromatography columns in a plurality.
Michael O. Fogwill, Martin Gilar, Joseph D. Michienzi, Wade P. Leveille, Geoff C. Gerhardt, Jeffrey Musacchio, Jason F. Hill, Sylvain G. Cormier
Filed: 22 Jun 21
Utility
Insulated Serial Column Chromatography Arrangements and Systems
23 Dec 21
Exemplary embodiments eliminate the need for column ovens in serial column chromatography arrangements and systems by using insulated sleeves.
Michael O. Fogwill, Martin Gilar, Joseph D. Michienzi, Wade P. Leveille, Geoff C. Gerhardt, Jeffrey Musacchio, Jason F. Hill, Sylvain G. Cormier
Filed: 22 Jun 21
Utility
Desalting Devices and Pressure-resistant Sizing Media
16 Dec 21
The present disclosure relates to a system for separating a sample including a device and a positive pressure source.
Anna Boardman, Wenjing Li, Beatrice Muriithi, Mingcheng Xu, Matthew A. Lauber
Filed: 7 May 21
Utility
Substituted Guanidino and Amidino Reagents and the Use Thereof for Protein Denaturation
16 Dec 21
The present disclosure relates to a system for a composition for protein denaturation.
Xiaoxiao Liu, Wenjing Li, Matthew A. Lauber
Filed: 7 May 21
Utility
Reducing Thermal Gradients In Chromatography Columns with Sub-ambient Cooling/super-ambient Heating and Radial Distribution
16 Dec 21
Exemplary embodiments may compensate for expected frictional heating or Joule-Thomson cooling in chromatography columns.
Michael O. Fogwill, Wade P. Leveille, Joseph D. Michienzi, Fabrice Gritti
Filed: 15 Jun 21
Utility
Solvent Reservoir Configuration for Steady Flow and Monitoring Solvent Level and Density
9 Dec 21
Disclosed herein are solvent reservoir systems for steady flow delivery and simultaneous monitoring of solvent level and solvent density within the solvent reservoir systems and methods for monitoring the solvent reservoir systems and providing feedback to a user or adjusting the systems in response to the monitored characteristics.
Sean Eric Anderson
Filed: 7 Jun 21
Utility
Determination of Dynamic Parameters for Adaptive Actuator Control
9 Dec 21
An actuator control system, mechanical testing system, and method for adaptive control of an actuator of a mechanical testing device is provided.
Kevin Alstrin
Filed: 25 Aug 21
Utility
Systems and Methods for Two-dimensional Liquid Chromatography Using Size Exclusion Chromatography As a First Dimension
9 Dec 21
Described herein are systems and methods used for carrying out a two-dimensional liquid chromatography process using size exclusion chromatography as a first dimension.
Stephan M. Koza, Pamela Iraneta, Hua Yang
Filed: 1 Jun 21
Utility
Device and Method for Tracking Wells In a Multi-well Plate
2 Dec 21
A well tracking device includes a rectangular frame including four sidewalls.
Anna Boardman, Melvin Blaze Muttikal Thomas, Wenhao Zhu, Kathryn Brennan, Jonathan Belanger
Filed: 25 May 21
Utility
Rheometer Having Resistance Heater and Cooling Device
2 Dec 21
Described are a method and device for controlling a temperature of a sample.
Scott Merrullo, Nigel Doe, Peter Foster
Filed: 21 May 21
Utility
Multiple Sample Channel Device for Liquid Chromatography
25 Nov 21
Described is a multi-channel fluidic device that includes a diffusion-bonded body having a device surface and a plurality of fluid channels.
Sylvain Gilles Cormier, Charles T. Murphy, Joseph D. Michienzi
Filed: 20 May 21
Utility
Methods for Heat-assisted Enzyme Digestion
11 Nov 21
The present disclosure relates to a method of digesting a sample comprising protein, the method comprising: adding the sample to an apparatus containing a buffer and a solid support surface comprising a surface coating, wherein the surface coating immobilizes enzyme while reducing undesired interactions between the sample and the solid support surface; immobilizing enzymes on the surface coating for digestion of the protein of the sample; and heating the sample to complete a heat-assisted digestion of the protein.
Wenjing Li, Beatrice Muriithi, Anna Boardman, Matthew A. Lauber
Filed: 7 May 21
Utility
Hetero-functional Coating for Conjugating Biomolecules on a Solid Support and Use Thereof for Bio Analysis
11 Nov 21
The present disclosure relates to a hetero-functional coating applied on a solid support.
Beatrice Muriithi, Wenjing Li, Oksana D. Tchoul, Matthew A. Lauber, Darryl W. Brousmiche
Filed: 7 May 21
Utility
Liquid Chromatography Based Detection and Quantitation of Phospho Prodrugs and Their Active Metabolites
11 Nov 21
The present disclosure relates to the use of vapor deposition coated flow paths for improved chromatography and sample analysis using liquid chromatography-mass spectrometry (LC/MS) or liquid chromatography-optical detection (LC/UV).
Matthew A. Lauber, Kevin Wyndham, Bonnie Alden, Dominic Foley, David Morrissey
Filed: 5 May 21
Utility
Multidimensional Liquid Chromatography System
11 Nov 21
Described are multidimensional liquid chromatography (MDLC) systems and methods of performing MDLC.
Michael O. Fogwill, Sylvain Gilles Cormier, Thomas Swann, Francis Patrick Tracey
Filed: 4 May 21
Utility
Differentiation of Natural Vitamin E from Synthetic Vitamin E and Quantification of Tocopherols by Supercritical Fluid Chromatography
4 Nov 21
The present disclosure provides methods for the separation and quantitation of enantiomers of vitamin E using supercritical fluid chromatography (SFC) or carbon dioxide-based chromatography on chiral columns.
Jinchuan Yang, Paul Rainville
Filed: 29 Apr 21
Utility
Seal for Separation Device
4 Nov 21
Described are apparatuses, devices, and systems implementing seals for separation devices.
Jonathan L. Belanger, Wade P. Leveille, Michael O. Fogwill, Joseph D. Michienzi, Jeffrey Musacchio
Filed: 27 Apr 21
Utility
System and Method for Solvent Mixing In a Chromatography System
4 Nov 21
A solvent mixing system includes a mixing tee, a centrifugal mixing path, and a low frequency blending mixer.
Neal Almeida
Filed: 27 Apr 21