230 patents
Page 9 of 12
Utility
Sample Injection for Liquid Chromatography Using Split Solvent Flow
27 May 21
Described herein are a selectable flow restriction device and a fluidic network for chromatographic sample dilution during injection.
Jason F. Hill, Sylvain Gilles Cormier, Martin Gilar
Filed: 11 Nov 20
Utility
Gradient Proportioning Valve
27 May 21
Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, an actuation mechanism having a piston located within a bored structure surrounding the piston, the actuation mechanism configured to open and close at least one of the plurality of conduits in a controlled manner where the piston and the bored structure have a tight tolerance configured to create a fluid tight seal, and a common outlet port configured to receive the fluid composition.
Timothy M. Raymond, Christopher Walden, Sean Anderson
Filed: 25 Nov 20
Utility
Passive Dampening Gradient Proportioning Valve
27 May 21
Disclosed is a gradient proportioning valve for liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of fluid conduits internal to the manifold, each of the plurality of fluid conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of fluid conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of fluid conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and a passive fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold where at least one of the plurality of fluid conduits is compliant.
Timothy M. Raymond, Christopher Walden, Sean Anderson
Filed: 25 Nov 20
Utility
Active Dampening Gradient Proportioning Valve
27 May 21
Disclosed is a gradient proportioning valve for use in liquid chromatography that includes a plurality of inlet ports configured to receive a plurality of fluids, a manifold connected to each of the plurality of inlet ports configured to mix the plurality of fluids in a controlled manner to provide a fluid composition, the manifold including a plurality of conduits internal to the manifold, each of the plurality of conduits receiving fluid through a respective one of the plurality of inlet ports, each of the plurality of conduits operatively communicable to a respective actuation mechanism configured to open and close each of the plurality of conduits in a controlled manner, a common outlet port configured to receive the fluid composition, and an active fluidic dampening system configured to dampen unwanted fluidic pressure pulses in the manifold.
Timothy M. Raymond, Christopher Walden, Sean Anderson
Filed: 25 Nov 20
Utility
Materials and Methods for Mixed Mode, Anion Exchange Reversed Phase Liquid Chromatography
13 May 21
In various aspects, the present disclosure pertains to high purity chromatographic materials that comprise a chromatographic surface wherein the chromatographic surface comprises a hydrophobic modifier and an ionizable modifier comprising one or more anion exchange moieties that are positively charged when ionized, as well as devices containing such materials.
Matthew A. Lauber, Xiaoxiao Liu, Qi Wang, Nicole Lawrence
Filed: 6 Nov 20
Utility
Techniques for Temperature Control of Separation Devices and Optical Detection Devices of Mass Analysis Systems
6 May 21
Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described.
Mark J. Basile, Jeffrey Musacchio, Michael O. Fogwill, Sebastien Besner, Joseph D. Michienzi, Wade P. Leveille
Filed: 30 Oct 20
Utility
Solvent Delivery System for Liquid Chromatography That Maintains Fluid Integrity and Pre-forms Gradients
29 Apr 21
A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column.
Steven J. Ciavarini, Stanley P. Pensak, JR., Jeffrey W. Finch, Keith Fadgen, Hongji Liu
Filed: 7 Jan 21
Utility
Method for Determining a Dwell Volume of a Chromatographic System
25 Feb 21
Described is a method for determining a dwell volume of a liquid chromatography system and a liquid chromatography system that can determined the system dwell volume.
Jason F. Hill, Martin Gilar, Abhijit Tarafder, Christopher DesJardins
Filed: 19 Aug 20
Utility
Chromatographic Compositions
18 Feb 21
Provided herein are stationary phase compositions comprising a chromatographic surface of porous or non-porous core material comprising a surface modifier for use in chromatographic separations.
Matthew A. Lauber, Daniel P. Walsh
Filed: 26 Oct 20
Utility
Affinity Resins and Sample Preparation Devices Based on Cartilaginous Fish Ignar Derived Binding Domains
18 Feb 21
The present disclosure relates to protein arrays and methods of using the same for the detection, quantification and characterization of biomolecules that specifically bind to the array among various other biomolecules in a biological sample.
Matthew A. Lauber, Xiaoxiao Liu, Beatrice Muriithi, Edouard S. P. Bouvier
Filed: 11 Aug 20
Utility
Mixer for Chromatography System
18 Feb 21
Described is a mixer for a chromatography system.
Peyton C. Beals, Sylvain Gilles Cormier, Richard Wayne Andrews
Filed: 10 Aug 20
Utility
Fitting for Fluidic Coupling In a Chromatography System
18 Feb 21
A fitting for fluidic coupling in a chromatography system includes a compression screw including an axial bore, a threaded portion, and a drive end, a tube assembly including a tube sleeve and an inner tube disposed through the sleeve, the tube sleeve and the inner tube each extending to an endface of the tube assembly, the tube sleeve including an outer surface, a seal body extending between a first endface and a second endface, the first endface abutting the endface of the tube assembly, the seal body including an outer surface, and a collar secured to the outer surface of the tube sleeve and the outer surface of the seal body.
Mark W. Moeller, William B. Clark, Charles T. Murphy
Filed: 12 Aug 20
Utility
Pressure Transducer, System and Method
4 Feb 21
A diaphragm pressure transducer includes a body having an outer surface and a diaphragm, a strain gauge including a resistive element located on the outer surface, a fluidic inlet, and a fluidic cavity enclosed by the body in fluidic communication with the fluidic inlet, the fluidic cavity having an upper surface.
Zongren Shang
Filed: 2 Apr 19
Utility
Interface Module for Robotic Loading and Unloading of a Sample Manager for Liquid Chromatography
4 Feb 21
Described is an interface module for robotic loading and unloading of a liquid chromatography sample manager.
Jeffrey Musacchio, Scott Kelley
Filed: 27 Jul 20
Utility
Link Chain, Chain System and Method
4 Feb 21
Described is a chain including a plurality of links pivotally connected to each other such that the chain is configured to bend in one direction without back-bending.
Jeffrey Musacchio
Filed: 28 Jul 20
Utility
Method of Loading Samples into a Sample Manager of a Chromatography System
4 Feb 21
Described is a method for loading a sample-vial carrier into a sample manager of a liquid chromatography system.
Jeffrey Musacchio
Filed: 27 Jul 20
Utility
Chromatographic Materials for the Separation of Unsaturated Molecules
28 Jan 21
The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture.
Darryl W. Brousmiche, Jacob N. Fairchild, Jason F. Hill, Giorgis Isaac, Michael F. Morris, Kevin D. Wyndham
Filed: 10 Jul 20
Utility
Multi-dimensional Chromatographic System for Analyzing Multiple Sample Components
30 Dec 20
A chromatography system includes a first chromatography column for receiving and separating a flow stream, a plurality of traps configured to trap a plurality of distinct flow segments exiting the first chromatography column during separation of the flow stream, and a second chromatography column operatively associated with the plurality of traps for receiving and separating the distinct flow segments.
Amanda B. Dlugasch, Thomas E. Wheat, Daniel Root, Jean-Michel Plankeele, Isabelle Francois, Edward R. Aig
Filed: 15 Sep 20
Utility
Coatings with Immobilized Affinity Ligands and Enzymes and Use Thereof In Liquid Chromatography Assays
30 Dec 20
A sample preparation device is provided for enriching a component of a sample.
Matthew A. Lauber, Mathew H. DeLano, Beatrice Muriithi, Xiaoxiao Liu, Anna Boardman
Filed: 25 Jun 20
Utility
Aptamer Based Affinity Capture Methods for the Selective Enrichment of Human Immunoglobulin FC Domains
30 Dec 20
A method of capturing human immunoglobulin Fc domains in a biofluid sample is provided.
Xiaoxiao Liu, Matthew A. Lauber
Filed: 25 Jun 20