1310 patents
Page 2 of 66
Utility
FGF21 Mimetic Antibodies and Uses Thereof
28 Dec 23
The present disclosure relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human β-klotho, and pharmaceutical compositions and methods of treatment comprising the same.
Regis CEBE, Stephane OLLAND, David Langdon YOWE
Filed: 15 May 23
Utility
Combination Therapy for the Treatment of Cancer
21 Dec 23
The present disclosure relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof.
Yan CHEN, Xizhong HUANG, Sunkyu KIM
Filed: 16 Aug 23
Utility
Method for preparing granules
19 Dec 23
A method for preparing granules.
Markus Krumme, Hans De Waard, Klaus-Peter Moll, Adrian Schmidt, Julien Taillemite
Filed: 30 Aug 18
Utility
1,3-substituted cyclobutyl derivatives and uses thereof
19 Dec 23
Donglei Liu, Julien Papillon, Stefan Peukert, James J. Powers
Filed: 24 Mar 22
Utility
MDM2 Inhibitors and Combinations Thereof
14 Dec 23
The present disclosure relates to a pharmaceutical combination comprising (a) an Mdm2 inhibitor and (b)(i) a MEK inhibitor and/or (b)(ii) Bcl2 inhibitor, particularly for use in the treatment of a cancer.
Giordano CAPONIGRO, Ensar HALILOVIC, Thomas HORN-SPIROHN, Joseph LEHAR
Filed: 13 Jan 23
Utility
Combination Therapy for the Treatment of Cancer
14 Dec 23
The present disclosure relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof.
Yan CHEN, Xizhong HUANG, Sunkyu KIM
Filed: 16 Aug 23
Utility
3-hydroxy-N-(3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)pyrrolidine-1-carboxamide Derivatives
14 Dec 23
Luca ARISTA, Christina HEBACH, Gregory John HOLLINGWORTH, Philipp HOLZER, Patricia IMBACH-WEESE, Rainer MACHAUER, Niko SCHMIEDEBERG, Anna VULPETTI, Thomas ZOLLER
Filed: 1 Dec 22
Utility
Targeted Plasma Protein Degradation
14 Dec 23
The present invention is directed to the bifunctional compounds and the use of such bifunctional compounds to lower plasma levels of extracellular target molecules by lysosomal degradation.
Martin Allan, Jeffrey T. BAGDANOFF, David Weninger Barnes, Kevin Clairmont, Thomas Smith, Shuangxi Wang
Filed: 4 Feb 21
Utility
Polyomavirus Neutralizing Antibodies
14 Dec 23
The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.
Johanna ABEND, Zorica DRAGIC, Adam Lloyd FEIRE, Mark KNAPP, Steven KOVACS, Elisabetta TRAGGIAI, Lichun WANG, Yongqiang WANG, Danqing WU, Qilong WU, Fangmin XU
Filed: 17 Mar 23
Utility
INTERLEUKIN-17 Inhibitors
7 Dec 23
The present invention relates to novel pyridine-N oxide substituted 2-formamido (N-phenyl and N-pyridyl) acetamide compounds that are Interleukin-17 (IL-17) inhibitors, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by IL-17.
Thomas Josef TROXLER, David ORAIN, Pascal FURET, Klaus WEIGAND, Achim SCHLAPBACH
Filed: 1 Nov 21
Utility
3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
5 Dec 23
Rohan Eric John Beckwith, Simone Bonazzi, Artiom Cernijenko, Fupeng Ma, Nathaniel F. Ware
Filed: 4 Oct 21
Utility
CKIT antibody drug conjugates
5 Dec 23
The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
Tinya Abrams, Steven Bruce Cohen, Dylan Daniel, Catrin Finner, Bernhard Hubert Geierstanger, Thomas Huber, William Mallet, Matthew John Meyer, Weijia Ou, Siew Ho Schleyer, Kathrin Ulrike Tissot-Daguette
Filed: 4 Jun 20
Utility
Method of treating structural and/or functional cardiac abnormalities by administering an anti-ActRII receptor antibody
5 Dec 23
The disclosure relates to novel uses and methods for preventing and/or treating heart disease, which employ a therapeutically effective amount of an ActRII receptor antagonist, e.g., an ActRII receptor binding molecule, e.g., an ActRII receptor antibody, such as the bimagrumab antibody.
Anthony Rosenzweig, Jason D. Roh, David J. Glass
Filed: 16 Mar 21
Utility
Antibody molecules to PD-1 and uses thereof
28 Nov 23
Antibody molecules that specifically bind to PD-1 are disclosed.
Gordon James Freeman, Arlene Helen Sharpe, Walter A. Blattler, Jennifer Marie Mataraza, Catherine Anne Sabatos-Peyton, Hwai Wen Chang, Gerhard Johann Frey
Filed: 10 Jul 20
Utility
Drug Containing Dissolvable Ocular Inserts and Method of Using Same
23 Nov 23
Polymeric eye inserts are provided that may be dissolvable when placed in the cul-de-sac of the eye.
Stephen John COLLINS, Howard Allen KETELSON, Walter R. LAREDO
Filed: 5 Oct 21
Utility
Use of an Erk Inhibitor for the Treatment of Myelofibrosis
23 Nov 23
The invention relates to the use of an ERK inhibitor in the treatment of myelofibrosis (MF).
Sime BRKIC, Hans MENSSEN, Sara MEYER, Thomas RADIMERSKI, Simona STIVALA
Filed: 7 Oct 21
Utility
Manufacture of Compounds and Compositions for Inhibiting the Activity of SHP2
23 Nov 23
Zhongbo FEI, Huanqing JIA, Wei LI, Jianhua WANG, Huangchao YU
Filed: 6 Jul 21
Utility
CD20 Therapies, CD22 Therapies, and Combination Therapies with a CD19 Chimeric Antigen Receptor (Car)-expressing Cell
23 Nov 23
The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a.
Hans Bitter, Jennifer Mary Bordeaux, Barbara Brannetti, Jennifer Brogdon, Naveen Kumar Dakappagari, Saar Gill, Steven Highfill, Lu Huang, Carl H. June, Ju Young Kim, Ming Lei, Na Li, Andreas Loew, Elena Orlando, Marco Ruella, Thai Tran, Jimin Zhang, Li Zhou
Filed: 22 Jun 23
Utility
Micro-droplet delivery device and methods
21 Nov 23
Micro-droplet delivery devices and methods are described where the device may comprise a piezoelectric actuator having a piezoelectric chip that is operatively coupled to a drug package under a preloading force.
Yehuda Ivri
Filed: 17 Apr 20
Utility
2-azaspiro[3.4]octane derivatives as M4 agonists
21 Nov 23
Amy Calhoun, Xin Chen, Kevin Matthew Gardinier, Edward Charles Hall, Keith Jendza, Nancy Labbe-Giguere, James Neef, Daniel Steven Palacios, Ming Qian, Michael David Shultz, Christopher G. Thomson, Kate Yaping Wang, Fan Yang
Filed: 8 Aug 22