1310 patents
Page 5 of 66
Utility
Methods of Treating New-onset Plaque Type Psoriasis Using IL-17 Antagonists
28 Sep 23
The present disclosure relates to methods for treating new-onset plaque-type psoriasis patients and inhibiting the progression of structural damage in these patients, using IL-17 antagonists, e.g., secukinumab.
Andreas FASTH, Jaime OLIVER
Filed: 7 Oct 22
Utility
Therapeutic Fusion Proteins
28 Sep 23
A determination is made that a mobile device is associated with a reference activity of a user based on motion, orientation, rotational, magnetic field, and/or location data provided by sensors of the device.
Sebastien IRIGARAY, Laurent KLEIN, Darko SKEGRO, Marco VILLANI, Karl WELZENBACH
Filed: 4 Sep 20
Utility
Process for concentration of antibodies and therapeutic products thereof
26 Sep 23
This present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C.
Charles M. Winter
Filed: 1 Nov 22
Utility
Collaboration platform for enabling collaboration on data analysis across multiple disparate databases
26 Sep 23
A platform and method for enabling collaboration on data analysis of life sciences data across disparate databases are disclosed.
Sidhyansh Saxena, Achim Plueckebaum, Badhri Srinivasan, Christian Diehl
Filed: 3 Dec 21
Utility
Binding Molecules Against Bcma and Uses Thereof
21 Sep 23
The present disclosure provides BCMA binding molecules that specifically bind to human BCMA, conjugates comprising the BCMA binding molecules, and pharmaceutical compositions comprising the BCMA binding molecules and the conjugates.
Aida ABUJOUB, John BLANKENSHIP, Tony FLEMING, Brian HOLMBERG, Connie HONG, Lu HUANG, Haihui LU
Filed: 21 Sep 22
Utility
Dosing Regimens for N-((5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL)-8-(2-METHYLPYRIDIN-3-YL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-5-AMINE, or a Pharmaceutically Acceptable Salt Thereof, for Use In Treating PRC2-MEDIATED Diseases or Disorders
21 Sep 23
Yi GU, Sebastien JEAY, Yi JIN, Marc LAISNEY, Christophe MEILLE, Prakash Dahyabhai MISTRY, Jonathan Guy MOGGS, Andreas WEISS, Mélanie Monique Laura WILBAUX
Filed: 25 May 21
Utility
Methods of Treating Ankylosing Spondylitis Using IL-17 Antagonists
21 Sep 23
The disclosure relates to novel regimens for treating an inflammatory arthritis, e.g., psoriatic arthritis, which employ a therapeutically effective amount of an Interleukin-17 (IL-17) antagonist, e.g., IL-17 binding molecule (e.g., IL-17 antibody or antigen binding fragment thereof, e.g., secukinumab) or IL-17 receptor binding molecule (e.g., IL-17 antibody or antigen binding fragment thereof).
Shephard MPOFU, Hanno RICHARDS, Karthinathan THANGAVELU, Matthias MACHACEK
Filed: 21 Oct 22
Utility
Engineered Heterodimeric Proteins
21 Sep 23
The present invention provides heterodimeric antibodies and fragments thereof and methods for their preparation, wherein the pairing of heavy and light chains has been improved.
Regis CEBE, Sebastien IRIGARAY, Darko SKEGRO
Filed: 26 Oct 22
Utility
Methods of Making Chimeric Antigen Receptor-expressing Cells
21 Sep 23
The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), and compositions and reaction mixtures comprising the same.
Felipe Bedoya, Saba Ghassemi, Carl H. June, Bruce L. Levine, Jan J. Melenhorst, Michael C. Milone, Daniel J. Powell, Jr., Zoe Zheng
Filed: 31 Jan 23
Utility
Compounds and compositions for treating conditions associated with NLRP activity
19 Sep 23
Gary Glick, Shomir Ghosh, William R. Roush
Filed: 1 Apr 22
Utility
Dosage regimen of an S1P receptor modulator
19 Sep 23
The present invention relates to a dosage regimen of an S1P receptor modulator or agonist in the course of the treatment of patients suffering from multiple sclerosis.
Craig Boulton, Pascale Burtin, Olivier David, Ana de Vera, Thomas Dumortier, Irene Hunt, Robert Schmouder, William C. Collins
Filed: 10 Jan 20
Utility
Crystalline Forms of 4-(7-HYDROXY-2-ISOPROPYL-4-OXO-4H-QUINAZOLIN-3-YL)-BENZONITRILE and Formulations Thereof
14 Sep 23
The present disclosure provides polymorphs and formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I).
Michael MUTZ, Fang WANG, Mei XIA
Filed: 4 Aug 21
Utility
Spiroindolone Compositions and Methods for the Treatment of Malaria
14 Sep 23
The present invention is directed to compositions containing spiroindolone compounds, in particular, (1′R,3′S)-5,7′-dichloro-6′-fluoro-3′-methyl-2′,3′,4′,9′-tetrahydrospiro[indoline-3,1′-pyrido[3,4-b]indol]-2-one, and methods of administering in the treatment of malaria, in particular severe malaria
Priyanga Wickramanayake, Xueyan Wang, Henricus Lambertus Gerrardus Maria Tiemessen, Paolo De Marco, Akouavi Kéli Norbette Asso
Filed: 16 Aug 21
Utility
Compounds and compositions for treating solid tumors by intratumoral administration
12 Sep 23
Michael Cooke, Shailaja Kasibhatla, Andrew T. Miller, Tom Yao-Hsiang Wu
Filed: 17 May 18
Utility
Fatty acids and their use in conjugation to biomolecules
12 Sep 23
Alexandra Marshall Bruce, Aaron Kanter, Aimee Richardson Usera, Jun Yuan, Frederic Zecri
Filed: 1 Jun 20
Utility
Compounds and compositions for inducing chondrogenesis
12 Sep 23
Ha-Soon Choi, Jiqing Jiang, James Paul Lajiness, Bao Nguyen, Hank Michael James Petrassi
Filed: 6 Jul 21
Utility
Treatment of B Cell Malignancies
7 Sep 23
The present disclosure relates to anti-BAFFR antibodies and binding fragments thereof, alone or in combination with additional agents, for use in the treatment of B cell malignancies, for example a B-cell non-Hodgkin's lymphoma.
Nadia HASSOUNAH, Anwesha CHAUDHURY, Somesh CHOUDHURY, Janghee WOO, Nicole Anju Punjabi KUNDAMAL
Filed: 4 Aug 21
Utility
Compositions and Methods for the Treatment of Hemoglobinopathies
7 Sep 23
The present invention is directed to compositions and methods for the treatment of hemoglobinopathies.
Muluken BELEW, Simone BONAZZI, James BRADNER, Artiom CERNIJENKO, Jennifer Stroka COBB, Natalie DALES, John Ryan KERRIGAN, Philip LAM, Hasnain Ahmed MALIK, Carsten RUSS, Frederic SIGOILLOT, Susan C. STEVENSON, Noel Marie-France THOMSEN, Pamela TING
Filed: 16 Dec 20
Utility
Computer method and system for deriving cell-to-cell spatial proximities
5 Sep 23
The invention relates, in part, to systems and methods for scoring a sample containing tumor tissue from a cancer patient.
Brian Little, Jennifer Bordeaux
Filed: 14 Feb 22
Utility
Biomarkers predictive of cytokine release syndrome
5 Sep 23
The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).
Alfred Garfall, Alex Ganetsky, Saar Gill, Simon Lacey, Jan J. Melenhorst, David Teachey, Eric Lancaster, Adam David Cohen, Pamela Shaw
Filed: 2 Sep 16