1310 patents
Page 4 of 66
Utility
Methods for Radiolabelling Psma Binding Ligands and Their Kits
19 Oct 23
The present disclosure relates to methods for radiolabelling PSMA binding ligands with a radioactive isotope, preferably 68Ga, 67Ga or 64Cu, and their kits.
Donato BARBATO, Elena CASTALDI, Lorenza FUGAZZA, Mattia TEDESCO
Filed: 28 Apr 21
Utility
Method of Treating Tendinopathy Using INTERLEUKIN-17 (IL-17)
19 Oct 23
The present disclosure relates to methods for treating tendinopathy, e.g., rotator cuff tendinopathy, using IL-17 antagonists, e.g., secukinumab.
Gerard Bruin, Shea Carter, Frank Kolbinger, Iain McInnes, Neal Millar, Linda Mindeholm, Matthias Schieker, Eckhard Weber
Filed: 9 Jan 23
Utility
ZBTB32 Inhibitors and Uses Thereof
19 Oct 23
The disclosure provides compositions and methods for treating diseases such as cancer.
Maria ESTEVEZ SILVA, Ye GAN, Yufei XU, Elena ORLANDO
Filed: 11 Jun 21
Utility
Sacubitril calcium salts
17 Oct 23
The invention relates to polymorphic forms of the calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester.
David Hook, Bin Hu, Florian Karl Kleinbeck, Ulrich Meier, Sibylle Mueller, Jean-Paul Mutz, Jan Schlomach, Paul Allen Sutton, Liladhar Murlidhar Waykole, Bernhard Wietfeld
Filed: 2 Jul 15
Utility
Pyrazolopyridine derivatives and uses thereof
17 Oct 23
The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.
Simone Bonazzi, Artiom Cernijenko, Jennifer Stroka Cobb, Natalie Alysia Dales, Janetta Dewhurst, Matthew James Hesse, Rama Jain, John Ryan Kerrigan, Hasnain Ahmed Malik, James R. Manning, Gary O'Brien, Andrew W. Patterson, Noel Marie-France Thomsen, Pamela Y F Ting
Filed: 14 Mar 22
Utility
10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1 ',2':4,5]pyrazino[1,2-B]pyridazine-3,5-dione Derivatives and Related Compounds as Inhibitors of the Orthomyxovirus Replication for Treating Influenza
12 Oct 23
Maxime Dauphinais, Rama Jain, Dennis Christofer Koester, James R. Manning, Vanessa Marx, Daniel Poon, Lifeng Wan, Xiaojing Michael Wang, Aregahegn Yifru, Qian Zhao
Filed: 27 Feb 23
Utility
Viral Vectors for the Treatment of Retinal Dystrophy
12 Oct 23
The present invention relates to viral vectors that are capable of delivering a heterologous gene to the retina and in particular delivering RLBP1 to RPE and Müller cells of the retina.
Chad Eric BIGELOW, Vivian CHOI, Thaddeus Peter DRYJA, Akshata Ninad GUJAR, Shawn Michael HANKS, Terri MCGEE, Seshidhar Reddy POLICE, Joanna VROUVLIANIS
Filed: 26 Jan 23
Utility
Vertebrate Cells and Methods for Recombinantly Expressing a Polypeptide of Interest
12 Oct 23
The present application pertains inter alia to an isolated vertebrate cell suitable for recombinant expression of a polypeptide of interest, wherein the vertebrate cell is altered to impair the function of the endogenous protease matriptase and wherein said cell comprises at least one heterologous polynucleotide encoding a polypeptide of interest and wherein the polypeptide of interest is secreted by the cell.
Holger Laux, Sandrine Romand, Ursula Bodendorf
Filed: 26 Oct 22
Utility
Dosing Regimen Comprising 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE Derivatives
12 Oct 23
The present disclosure relates to dosing regimens comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione compounds or pharmaceutical compositions, pharmaceutical formulations, or combinations comprising the same; and methods of using such compounds, combinations, and compositions in the treatment or prevention IKAROS Family Zinc Finger 2 (IKZF2)-dependent diseases or disorders or where reduction of IKZF2 or IKZF4 protein levels can ameliorate a disease, for example, the treatment of cancers.
Eva Marie Genevieve D'HENNEZEL, Yi GU, Lisa Marie KATTENHORN, Fariba KHANSHAN, Eunice Lee KWAK, Joanne Choi RANDOLPH, Christopher Sean STRAUB
Filed: 21 Jun 21
Utility
Combination Therapy of a Raf Inhibitor and a Mek Inhibitor for the Treatment of Sarcoma
12 Oct 23
The present invention relates to a pharmaceutical combination comprising (a) a Raf inhibitor as defined herein (naporafenib), or a pharmaceutically acceptable salt thereof and (b) a MEK inhibitor, particularly trametinib, particularly for use in the treatment of sarcoma.
Giordano CAPONIGRO, Vesselina COOKE, Angelina VASEVA
Filed: 30 Aug 21
Utility
Methods of Treating Psoriasis Using IL-17 Antagonists
12 Oct 23
The disclosure relates to novel regimens for treating psoriasis, which employ a therapeutically effective amount of an IL-17 antagonist, e.g., an IL-17 binding molecule, e.g., an IL-17 antibody, such as the secukinumab antibody, or an IL-17 receptor binding molecule, e.g., an IL-17 receptor antibody.
Achim GUETTNER, Matthias MACHACEK, Charis PAPAVASSILIS, Oliver SANDER
Filed: 2 Dec 22
Utility
Methods of Treating Generalized Pustular Psoriasis (GPP) Using IL-17 Antagonists
12 Oct 23
The disclosure is directed to methods, treatment regimens, uses, kits and therapies for treating Generalized Pustular Psoriasis (GPP).
Charis PAPAVASSILIS, Oliver SANDER, Tomohiro SHIMA, Susumu KITAMURA
Filed: 19 Dec 22
Utility
Radiolabelled Grpr-antagonist for Use As Theragnostic
12 Oct 23
The present disclosure relates to gastrin-releasing peptide receptor (GRPR) targeting pharmaceuticals and their use in a theragnostic approach for selection and therapy of subjects with GRPR-expressing malignancies.
Daniela CHICCO, Maurizio F. MARIANI, Francesca ORLANDI, Antje WEGENER
Filed: 23 Sep 20
Utility
Anti-CD40 antibodies for use in prevention of graft rejection
10 Oct 23
The disclosure relates to methods, treatment regimens, uses, kits and therapies for preventing graft rejection in solid organ transplantation, by employing anti-CD40 antibodies.
Pascal Espie, Boerje Haraldsson, James Rush
Filed: 11 Apr 19
Utility
Antibodies to PMEL17 and conjugates thereof
10 Oct 23
This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates comprising antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor.
Matthew Burger, Joseph Anthony D'Alessio, Tony Fleming, Vivek Rauniyar, Eusebio Manchado Robles, Christian Kunz, Markus Waldhuber
Filed: 18 Dec 19
Utility
Amino Pyrimidine Derivatives
5 Oct 23
The present invention describes new amino pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk).
Daniela ANGST, François GESSIER, Anna VULPETTI
Filed: 1 May 23
Utility
CD28 Compositions and Methods for Chimeric Antigen Receptor Therapy
5 Oct 23
The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein.
Avery D. Posey, Sonia Guedan Carrio
Filed: 16 Nov 22
Utility
Multi-dose Ocular Fluid Delivery System
28 Sep 23
Multi-dose ocular fluid delivery devices are provided.
Reynaldo Quintana, Yehuda Ivri
Filed: 3 May 23
Utility
Carboxamide Derivatives
28 Sep 23
Kamlesh Jagdis BALA, Andrew BREARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nichola SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef TROXLER-SCHWAB, Joe WRIGGLESWORTH
Filed: 16 May 23
Utility
Compositions and Methods for In Vivo Generation of Car Expressing Cells
28 Sep 23
Aspects of this disclosure relate generally to the use of biomaterials for the in vivo generation of CAR expressing cells.
Sandeep Tharian Koshy, Glenn Dranoff, Maria Anna Sofia Broggi, Chris Bridgeman, Stephen Michael Canham, Yoel Melles, Regis Cebe, Brian Walter Granda, Louise Mary Treanor, Shyamali Jayashankar, Jennifer Yang, Amy Rayo, Andrew Patrick Price, Darko Skegro, Justine Guyot, Tushar Dattu Apsunde, Cameron Chuck-munn Lee, Michael Bardroff, Sandra Miller
Filed: 20 Aug 21