84 patents
Page 2 of 5
Utility
Systems and Methods for Cancer Condition Determination Using Autoencoders
18 Nov 21
A method for discriminating a cancer state is provided.
Virgil Nicula, Joshua Newman
Filed: 4 Mar 21
Utility
Using nucleic acid size range for noninvasive cancer detection
9 Nov 21
Size-band analysis is used to determine whether a chromosomal region exhibits a copy number aberration or an epigenetic alteration.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang
Filed: 1 Nov 18
Utility
Generating Cancer Detection Panels According to a Performance Metric
21 Oct 21
A system generates a cancer detection panel.
Jing Xiang, Anton Valouev
Filed: 19 Apr 21
Utility
Cancer Classification Using Patch Convolutional Neural Networks
21 Oct 21
Methods for determining a disease condition of a subject of a species are provided that comprises obtaining a dataset of fragment methylation patterns determined by methylation sequencing of nucleic acid from a biological sample of the subject.
Virgil Nicula, Ognjen Nikolic, Yasushi Saito, Marius Eriksen, Josh Newman, Darya Filippova, Alexander Yip, Oliver Venn, Joerg Bredno, Qinwen Liu, Alexander P. Fields
Filed: 11 Dec 20
Utility
Cancer Classification with Synthetic Training Samples
7 Oct 21
Methods and systems for detecting cancer and/or determining a cancer tissue of origin are disclosed.
M. Cyrus Maher, Samuel S. Gross, Joshua Newman, Joerg Bredno, Ognjen Nikolic
Filed: 29 Mar 21
Utility
Cancer Classification with Genomic Region Modeling
7 Oct 21
Methods and systems for detecting cancer and/or determining a cancer tissue of origin are disclosed.
Samuel S. Gross, Joshua Newman, Virgil Nicula
Filed: 29 Mar 21
Utility
Systems and Methods for Estimating Cell Source Fractions Using Methylation Information
23 Sep 21
A method of identifying a plurality of features for estimating subject cell source fraction is provided.
Jing XIANG, Robert Abe Paine Calef
Filed: 18 Dec 20
Utility
Identifying Methylation Patterns That Discriminate or Indicate a Cancer Condition
23 Sep 21
Systems and methods of identifying methylation patterns discriminating or indicating a cancer condition are provided.
Collin Melton, Earl Hubbell, Oliver Claude Venn
Filed: 26 Feb 21
Utility
Systems and Methods for Calling Variants Using Methylation Sequencing Data
16 Sep 21
An allelic position variant calling method using a prior genotype probability at the allelic position is provided.
Pranav Singh, Christopher Chang, Collin Melton, Oliver Claude Venn
Filed: 25 Feb 21
Utility
Higher target capture efficiency using probe extension
14 Sep 21
Aspects of the invention include methods for preparing an enriched sequencing library.
Nicholas Eattock, Byoungsok Jung, Justice Williams
Filed: 30 Mar 18
Utility
Method for Accurate Quantification of Genomic Copies In Cell-free Dna
9 Sep 21
Described herein are methods and systems for quantifying low molecular weight nucleic acid molecules in a biological sample amongst a background of high molecular weight contamination.
Hamed AMINI, Sudha NAGARAJU, Alex ARAVANIS, Arash JAMSHIDI
Filed: 11 Aug 17
Utility
Methylation Markers and Targeted Methylation Probe Panel
5 Aug 21
The present description provides a cancer assay panel for targeted detection of cancer-specific methylation patterns.
Samuel S. GROSS, Oliver Claude VENN, Seyedmehdi SHOJAEE, John BEAUSANG, Arash JAMSHIDI
Filed: 26 Mar 21
Utility
Biterminal Dna Fragment Types In Cell-free Samples and Uses Thereof
5 Aug 21
The present disclosure describes techniques for measuring quantities (e.g., relative frequencies) of end motif pairs of cell-free DNA fragments in a biological sample of an organism for measuring a property of the sample (e.g., fractional concentration of clinically-relevant DNA) and/or determining a pathology of the organism based on such measurements.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Diana Siao Cheng Han, Meng Ni
Filed: 7 Jan 21
Utility
Methylation Markers and Targeted Methylation Probe Panel
5 Aug 21
The present description provides a cancer assay panel for targeted detection of cancer-specific methylation patterns.
Samuel S. GROSS, Oliver Claude VENN, Seyedmehdi SHOJAEE, John BEAUSANG, Arash JAMSHIDI
Filed: 26 Mar 21
Utility
Methods for Tagging and Amplifying Rna Template Molecules for Preparing Sequencing Libraries
1 Jul 21
Aspects of the invention include methods for preparing sequencing libraries comprising a plurality of RNA molecules.
Matthew Larson
Filed: 10 Mar 21
Utility
Systems and Methods for Evaluating Longitudinal Biological Feature Data
3 Jun 21
Systems and methods are provided for determining whether a test subject has a disease condition.
M. Cyrus Maher, Alex Aravanis, Angela Lai, Oliver Claude Venn, Richard Rava, Jing Xiang, Joseph Marcus
Filed: 25 Nov 20
Utility
Endpoint Analysis In Early Cancer Detection
6 May 21
A system and method for determining a presence of cancer in a test sample from a test subject comprising a set of fragments of deoxyribonucleic acid (DNA) is described.
Peter D. Freese, Collin Melton, Earl Hubbell
Filed: 9 Oct 20
Utility
Cancer Classification with Tissue of Origin Thresholding
29 Apr 21
Methods and systems for detecting cancer and/or determining a cancer tissue of origin are disclosed.
Qinwen Liu, Oliver Claude Venn, Samuel S. Gross, Robert Abe Paine Calef
Filed: 9 Oct 20
Utility
Methods of Preparing and Analyzing Cell-free Nucleic Acid Sequencing Libraries
22 Apr 21
Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample includes double-stranded DNA (dsDNA), damaged dsDNA (e.g., nicked dsDNA), and single-stranded DNA (ssDNA) molecules.
Matthew H. Larson, Hyunsung John Kim, Nick Eattock, Xiao Yang
Filed: 23 Dec 20
Utility
Systems and Methods for Using Pathogen Nucleic Acid Load to Determine Whether a Subject Has a Cancer Condition
22 Apr 21
Methods for screening for a cancer condition in a subject are provided.
M. Cyrus Maher, Anton Valouev, Seyedmehdi Shojaee, Oliver Claude Venn
Filed: 24 Apr 19