84 patents
Page 5 of 5
Utility
Inferring Selection In White Blood Cell Matched Cell-free Dna Variants And/or In Rna Variants
20 Nov 19
Methods and systems for detecting positive, neutral, or negative selection at a locus include obtaining a test sample of cell-free nucleic acids from a subject, preparing a sequencing library of the cell-free nucleic acids, sequencing the library to obtain a plurality of sequence reads, analyzing the sequence reads to detect and quantify one or more somatic mutations at the locus, determining a selection coefficient for the locus, and comparing the selection coefficient with a threshold value to detect positive, neutral, or negative selection at the locus.
Oliver Claude Venn, Earl Hubbell
Filed: 19 May 19
Utility
Methods and Systems for High Fidelity Sequencing
6 Nov 19
Systems and methods for high fidelity sequencing and identification of rare mutations at dilute concentrations in a sample are described herein.
Oliver Claude Venn, Alexander Tilo Dilthey
Filed: 21 Jan 17
Utility
Size-tagged Preferred Ends and Orientation-aware Analysis for Measuring Properties of Cell-free Mixtures
6 Nov 19
Various applications can use fragmentation patterns related of cell-free DNA, e.g., plasma DNA and serum DNA.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Kun Sun
Filed: 2 May 19
Utility
Multi-Assay Prediction Model for Cancer Detection
16 Oct 19
A predictive cancer model generates a cancer prediction for an individual of interest by analyzing values of one or more types of features that are derived from cfDNA obtained from the individual.
Earl Hubbell, Samuel S. Gross, Darya Filippova, Ling Shen, Oliver Claude Venn, Alexander Weaver Blocker, Nan Zhang, Tara Maddala, Alex Aravanis, Qinwen Liu, Anton Valouev, Virgil Nicula
Filed: 14 Apr 19