84 patents
Page 3 of 5
Utility
Systems and Methods for Diagnosing a Disease Condition Using On-target and Off-target Sequencing Data
8 Apr 21
Systems and methods for determining whether a subject has a disease condition in a set of disease conditions are provided.
Anton Valouev, Jing Xiang, Collin Melton
Filed: 16 Sep 20
Utility
Systems and Methods for Determining Tumor Fraction In Cell-free Nucleic Acid
8 Apr 21
Systems and methods are disclosed for determining tumor fraction in cell-free nucleic acid of a liquid biological sample of a subject.
Oliver Claude VENN, Earl HUBBELL, Onur SAKARYA
Filed: 16 Apr 19
Utility
Methods and Systems for Screening for Conditions
25 Mar 21
Methods are provided to improve the positive predictive value for cancer detection using cell-free nucleic acid samples.
Rongsu QI, Farooq A. SIDDIQUI, Srinka GHOSH
Filed: 11 Sep 20
Utility
Systems and Methods for Determining Tumor Fraction
4 Mar 21
Systems and methods for determining a tumor fraction for a subject are provided.
Anton Valouev, Jing Xiang
Filed: 23 Jul 20
Utility
Systems and Methods for Determining Consensus Base Calls In Nucleic Acid Sequencing
4 Mar 21
Systems and methods for determining consensus base calls in nucleic acid sequencing are provided.
Anton Valouev, Shirley Chen, David Burkhardt, Christopher Chang
Filed: 28 Aug 20
Utility
Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
2 Feb 21
Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample includes double-stranded DNA (dsDNA), damaged dsDNA (e.g., nicked dsDNA), and single-stranded DNA (ssDNA) molecules.
Matthew H. Larson, Hyunsung John Kim, Nick Eattock, Xiao Yang
Filed: 24 Oct 19
Utility
Methylation Markers and Targeted Methylation Probe Panel
28 Jan 21
The present description provides a cancer assay panel for targeted detection of cancer-specific methylation patterns.
Samuel S. Gross, Hamid Amini, Arash Jamshidi, Seyedmehdi Shojaee, Srinka Ghosh, Rongsu Qi, M. Cyrus Maher, Alexander P. Fields, Oliver Claude Venn
Filed: 1 Oct 20
Utility
Methylation Markers and Targeted Methylation Probe Panel
21 Jan 21
The present description provides a cancer assay panel for targeted detection of cancer-specific methylation patterns.
Samuel S. Gross, Hamid Amini, Arash Jamshidi, Seyedmehdi Shojaee, Srinka Ghosh, Rongsu Qi, M. Cyrus Maher, Alexander P. Fields, Oliver Claude Venn
Filed: 1 Oct 20
Utility
Determining Linear and Circular Forms of Circulating Nucleic Acids
30 Dec 20
Techniques are provided for analyzing circular DNA in a biological sample (e.g., including cell-free DNA, such as plasma).
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Lu Ji, Tsz Kwan Sin, Haiqiang Zhang, Jiaen Deng
Filed: 24 Mar 20
Utility
Systems and Methods for Estimating Cell Source Fractions Using Methylation Information
9 Dec 20
Systems and methods are disclosed for determining a cell source fraction in a biological sample of a test subject.
Oliver Claude Venn
Filed: 17 Dec 19
Utility
Systems and Methods for Determining Whether a Subject Has a Cancer Condition Using Transfer Learning
25 Nov 20
Systems and methods for classifier training are provided.
M. Cyrus MAHER
Filed: 21 May 20
Utility
Model-based Featurization and Classification
18 Nov 20
In various embodiments, an analytics system uses models to determine features and classification of disease states.
Alexander P. Fields, John F. Beausang, Oliver Claude Venn, Arash Jamshidi, M. Cyrus Maher, Qinwen Liu, Jan Schellenberger, Joshua Newman, Robert Calef, Samuel S. Gross
Filed: 12 May 20
Utility
Methods for single-stranded nucleic acid library preparation
2 Nov 20
Aspects of the invention relate to methods and compositions for preparing and analyzing a single-stranded sequencing library from a double-stranded DNA (e.g., double-stranded cfDNA) sample.
Arash Jamshidi, Hamed Amini
Filed: 26 Oct 17
Utility
Methylation-based False Positive Duplicate Marking Reduction
28 Oct 20
An analytics system marks duplicate fragments from an initial set of fragments from a subject.
Alexander S. Yip, Samuel S. Gross, Seyedmehdi Shojaee
Filed: 2 Apr 20
Utility
Systems and Methods for Tumor Fraction Estimation from Small Variants
28 Oct 20
Systems and methods for cancer subject tumor fraction estimation comprise obtaining a first plurality of nucleic acid fragment sequences from the subject's liquid biological sample.
Samuel S. Gross, Joshua Newman, Pranav Parmjit Singh, Collin Melton, Oliver Claude Venn, Earl Hubbell
Filed: 15 Apr 20
Utility
Diagnostic Applications Using Nucleic Acid Fragments
7 Oct 20
Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count, the fragmentation patterns, and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wai Kei Lam
Filed: 23 Apr 20
Utility
Stratification of Risk of Virus Associated Cancers
7 Oct 20
Provided herein are methods and systems for stratifying risk for a subject to develop a pathogen-associated disorder based on analysis of cell-free nucleic acid molecules from a biological sample of the subject.
Yuk-Ming Dennis LO, Rossa Wai Kwun CHIU, Kwan Chee CHAN, Peiyong JIANG, Wai Kei LAM, Lu JI
Filed: 31 Mar 20
Utility
Systems and Methods for Enriching for Cancer-derived Fragments Using Fragment Size
16 Sep 20
Systems and methods for determining a cancer class of a subject are provided in which a plurality of sequence reads, in electronic form, are obtained from a biological sample of the subject.
Darya Filippova, Matthew H. Larson, M. Cyrus Maher, Monica Portela dos Santos Pimentel, Robert Abe Paine Calef
Filed: 11 Mar 20
Utility
Methods for Preparing a Sequencing Library from Single-stranded Dna
19 Aug 20
Methods for generating a sequencing library from a sample comprising a plurality of single-stranded DNA molecules are provided, along with methods of using the generated sequencing library for detecting cancer, determining cancer stage, monitoring cancer progression, and/or determining a cancer classification from a test sample obtained from a subject.
Farnaz Absalan, Gordon Cann, Arash Jamshidi
Filed: 13 Sep 18
Utility
Methods of Analyzing Nucleic Acid Fragments
5 Aug 20
Provided herein are methods for enriching a biological sample for a target nucleic acid, and analyzing the nucleic acid.
Eugeni NAMSARAEV, Maneesh JAIN
Filed: 18 Mar 20