747 patents
Page 5 of 38
Utility
Superconducting nonlinear asymmetric inductive element and related systems and methods
22 Aug 23
A superconducting device includes two nodes and a Josephson junction coupled between the two nodes, wherein the Josephson junction is characterized by a superconducting phase difference, φ, wherein the superconducting device has a potential that varies as a function of the superconducting phase difference, φ, and has a single potential well.
Nicholas Frattini, Uri Vool, Shyam Shankar, Anirudh Narla, Katrina Sliwa, Michel Devoret, Volodymyr Sivak
Filed: 11 Dec 18
Utility
Chimeric small molecules for the recruitment of antibodies to cancer cells
15 Aug 23
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells.
David Spiegel, Ryan Murelli, Andrew Zhang
Filed: 17 May 21
Utility
Multiplex genome engineering in eukaryotes
15 Aug 23
Compositions and methods for gene editing are provided.
Edward Barbieri, Farren Isaacs
Filed: 27 Apr 17
Utility
Compositions and Methods for Selective Detection and/or Inhibition of Bacterial Pathogens in Microbial Communities
10 Aug 23
The present disclosure relates, in one aspect, to the unexpected discovery that the native enzymatic machinery of pathogenic bacteria can be harnessed to develop biosensors and antimicrobials that target disease-causing microbes in the gut.
Stavroula Hatzios, Alicia Decolli
Filed: 25 Jun 21
Utility
Compounds and methods for treating or preventing anterior segment ocular disorders and/or retinal degenerations
8 Aug 23
The invention provides a method of treating retinal degenerations, such as but not limited to anterior segment ocular disorders and/or age-related macular degeneration (AMD), in a subject, the method comprising administering to the subject a pharmaceutical composition comprising an effective amount of a compound of formula (1) or formula (2).
Mark Fields, Lucian Del Priore, Huey Cai, Denton Hoyer
Filed: 8 Jul 20
Utility
Blockade of miR4661-3p binding to IL-17A mRNA with site-specific target site blocker prevents neuro-inflammatory-mediated disease
8 Aug 23
In various aspects and embodiments the invention provides compositions and methods useful in the treatment of inflammatory disease, in particular, multiple sclerosis.
Jeffrey Bender, Vinod Ramgolam, Timur Yarovinsky
Filed: 7 May 19
Utility
Phosphopeptide-encoding oligonucleotide libraries and methods for detecting phosphorylation-dependent molecular interactions
8 Aug 23
The present invention relates to libraries of phosphopeptide-encoding oligonucleotides and methods of preparing such libraries.
Jesse Rinehart, Karl Barber, Farren Isaacs, Jeffrey R Sampson
Filed: 18 Feb 19
Utility
INTERLEUKIN-18 Variants and Methods of Use
3 Aug 23
The present invention provides compositions and methods comprising an activator of interleukin-18 (IL-18) activity for use in therapeutic and non-therapeutic applications.
Aaron Ring, Ting Zhou, Suzanne Fischer
Filed: 15 Nov 22
Utility
PanK Modulators and Methods Using Same
3 Aug 23
The disclosure relates, in certain aspects, to the discovery of certain compounds that are useful to treat and/or prevent fungal infections in a subject.
Choukri Ben Mamoun, Peter Gareiss, Jose Thekkiniath, Denton Hoyer, Yulia Surovtseva, William Hungerford, Mark Plummer, Antonella Stroppa, Joy Chiu
Filed: 23 Jun 21
Utility
Network for Improved Verification Speed with Tamper Resistant Data
27 Jul 23
A method is disclosed.
Mahdi Zamani, Mahnush Movahedi, Mariana Raykova
Filed: 1 Mar 23
Utility
Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins
27 Jul 23
The present disclosure is directed to bifunctional small molecules which contain a circulating protein binding moiety (CPBM) linked through a linker group to a cellular receptor binding moiety (CRBM) which is a membrane receptor of degrading cell such as a hepatocyte or other degrading cell.
David Spiegel, David Caianiello, Mengwen Zhang
Filed: 30 Jan 23
Utility
Poly(amine-co-ester) Polymers with Modified End Groups and Enhanced Pulmonary Delivery
27 Jul 23
Poly(amine-co-ester) polymers, methods of forming active agent-load polyplexes and particles therefrom, and methods of using them for delivery of nucleic acid agents with optimal uptake have been developed.
W. Mark Saltzman, Yuhang Jiang, Molly Grun, Alexandra Suberi
Filed: 27 May 21
Utility
Compositions and Methods for Delivery of Nucleic Acids to Cells
20 Jul 23
Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided.
Elias QUIJANO, Peter GLAZER
Filed: 31 Aug 20
Utility
Methods of Treating, Ameliorating, Shortening Duration, and/or Reversing Symptoms and/or Complications of a Coronavirus Infection
20 Jul 23
The present disclosure relates, in part, to methods of treating, ameliorating, shortening duration, and/or reversing at least one symptom and/or complication in a human subject with a coronavirus infection with camostat, or a pharmaceutically acceptable salt or solvate thereof.
Joseph M. Vinetz
Filed: 29 Jun 21
Utility
Compositions and Methods for Treating And/or Preventing Coagulopathy And/or Sepsis In Patients Suffering from Bacterial And/or Viral Infections
20 Jul 23
The present disclosure includes compositions and methods for treating, ameliorating, and/or preventing immune mediated pathology associated with a bacterial and/or viral infection.
Paul Stabach, Demetrios Braddock
Filed: 8 Jun 21
Utility
Spak/osr Inhibitors and Methods of Using Same
20 Jul 23
The present disclosure provides SPAK/OSR inhibitors.
Jesse RINEHART, Farren ISAACS, Andre LEVCHENKO, Denton HOYER, Apiwat WANGWEERAWONG, William HUNGERFORD, Mark PLUMMER, Alfredo QUINONES-HINOJOSA, Paula Valentina SCHIAPPARELLI
Filed: 4 Dec 20
Utility
Compositions for Treating Ectopic Calcification Disorders, and Methods Using Same
20 Jul 23
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification.
Demetrios Braddock, Enrique DE LA CRUZ
Filed: 19 Dec 22
Utility
Multiplex detection of intracellular or surface molecular targets in single cells
18 Jul 23
This disclosure demonstrates an approach that translates synthetic DNA codes to spatial codes registered in nanoliter microchambers for multiplexed measurement of nearly any type of molecular targets (e.g., miRNAs, mRNAs, intracellular and surface proteins) in single cells.
Rong Fan, Yao Lu, Nayi Wang
Filed: 17 Jul 17
Utility
Treatment of MGMT Deficient Cancer with 2-FLUOROETHYL-SUBSTITUTED Nitrosoureas and Other Compounds
6 Jul 23
Disclosed are nitrosourea and other compounds, pharmaceutical composition, and methods of treating cancers that are MGMT deficient regardless of their MMR status and particularly compounds, pharmaceutical compositions, and methods of treating cancers that are both MGMT and MMR deficient.
Seth Herzon, Ranjit Bindra, Kingson Lin
Filed: 16 Dec 22
Utility
Tnap Locally Administered for Promoting Periodontal Health
29 Jun 23
Methods are disclosed for treating periodontal disease, peri-implantitis, or to preserve a tooth socket in a subject.
Martha J. Somerman, Nadine Laure Samara, Atsuhiro Nagasaki, Demetrios T. Braddock, Brian Lee Foster, Jose Luis Millan
Filed: 31 Dec 20