747 patents
Page 6 of 38
Utility
Methods for Detecting Respiratory Viral Infection
29 Jun 23
The present disclosure concerns methods of detecting viral respiratory infections by analyzing biomarkers in a viral transport medium sample.
Ellen FOXMAN, Marie LANDRY
Filed: 11 Oct 17
Utility
Rig-i Agonists and Methods Using Same
29 Jun 23
The present invention provides combination therapies that are useful for treating and/or preventing certain cancers.
Akiko Iwasaki, Anna Marie Pyle, Xiaodong Jiang, Olga Fedorova
Filed: 13 Jul 22
Utility
Drug Therapy to Inhibit Chemotherapy-induced Adverse Effects and Related Pharmaceutical Compositions, Diagnostics, Screening Techniques and Kits
29 Jun 23
The invention provides a method of treatment comprising reducing therapy-induced adverse effects (TIAE), including chemotherapy-induced adverse effects (CIAE), such as chemotherapy-induced peripheral neuropathy (CIPN) and/or chemotherapy-induced cardiovascular adverse effects (CICAE) in a subject being treated with a CIAE-inducing anti-cancer active ingredient by co-administering to the subject a pharmaceutically effective amount of a NCS-1-protective composition.
Barbara Ehrlich, Sara Rockwell, Jennifer Benbow
Filed: 2 Dec 22
Utility
Compounds and Methods for the Enhanced Degradation of Targeted Proteins
29 Jun 23
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention.
Andrew P. Crew, Craig M. Crews, Xin Chen, Hanqing Dong, Caterina Ferraro, Yimin Qian, Kam Siu, Jing Wang, Meizhong Jin, Michael Berlin, Kurt Zimmermann, Lawrence Snyder
Filed: 13 Sep 22
Utility
Novel Precatalyst Scaffolds for Cross-coupling Reactions, and Methods of Making and Using Same
29 Jun 23
The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts.
Nilay HAZARI, Patrick MELVIN, Damian HRUSZKEWYCZ
Filed: 27 Feb 23
Utility
Methods and Compositions to Treat Vascular Leak
29 Jun 23
Provided are anti-syndecan-2 antibodies and compositions comprising said antibody and methods useful for treating acute respiratory distress syndrome, including coronavirus disease 2019-induced acute respiratory distress syndrome, in a subject in need thereof.
Michael Simons, Federico Corti
Filed: 21 May 21
Utility
Compositions and methods of treating or preventing fibrotic lung diseases
30 May 23
The present invention includes a method of preventing and/or treating a fibrotic lung disease in a subject.
Naftali Kaminski, Guoying Yu, Argyrios Tzouvelekis
Filed: 26 Jun 18
Utility
Compositions and Methods for Generating Tick Immunity
25 May 23
In various aspects and embodiments the invention provides methods and compositions for generating tick immunity.
Erol FIKRIG, Sukanya NARASIMHAN
Filed: 16 Nov 22
Utility
Small Molecule Adapter Regulated, Target Specific Chimeric Antigen Receptor Bearing T Cells (Smart Cars)
25 May 23
In one embodiment, the invention provides a chimeric antigen receptor (CAR) T cell which is conjugated to a bi-functional molecule which is specific for both an extracellular binding domain of the chimeric antigen receptor (CAR) T cell and prostate-specific membrane antigen (PSMA).
David Spiegel, Jesse Collins, Viswanathan Muthusamy
Filed: 3 Jul 18
Utility
RIG-I Agonists and Methods of Using Same
25 May 23
The present invention provides RIG-I agonists.
Anna Marie Pyle, Olga Fedorova
Filed: 29 Aug 22
Utility
Leptospiral Proteins and Uses Thereof
18 May 23
The invention provides compositions and methods for using Leptospiral virulence modifying (VM) proteins or fragments or fusions thereof, as vaccines and as therapeutic agents for the treatment of cancer.
Joseph VINETZ, Michael MATTHIAS
Filed: 4 Feb 21
Utility
Systems and Methods for Secure Data Sharing
18 May 23
One aspect of the invention provides a method for secure sharing of data.
Daniel Boffa, Michael Fischer, Jonathan Hochman
Filed: 18 Nov 22
Utility
Tissue engineering of lung
16 May 23
The present invention relates to compositions comprising a decellularized tissue.
Elizabeth Calle, Laura E. Niklason, Thomas Petersen, Liqiong Gui
Filed: 21 Dec 18
Utility
Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids
16 May 23
Compositions, systems, and methods for preparation of polypeptides having multiple iterations of non-standard amino acids are provided.
Farren Isaacs, Miriam Amiram, Adrian Haimovich, Dieter Soil
Filed: 23 Oct 19
Utility
Methods for treating SARS-CoV-2 infection
16 May 23
The present disclosure provides small hairpin nucleic acid molecules capable of stimulating interferon production.
Anna Marie Pyle, Akiko Iwasaki, Tianyang Mao
Filed: 30 Mar 22
Utility
Integrated silicon optical amplifier with reduced residual pump
16 May 23
An optical amplifier device employing a Mach-Zehnder Interferometer (MZI) that reduces the amount of residual pump power in the optical output of the amplifier is disclosed.
Anthony L. Lentine, Michael Gehl, Peter Rakich, Shai Gertler, Nils Otterstrom
Filed: 16 Nov 20
Utility
Biphasic Material and Stretchable Circuit Board
11 May 23
Provided are biphasic compositions including a quantity of a conductive liquid and a plurality of a particulate suspended in the quantity of conductive liquid, wherein there is sufficient wetting between the solid particles and the conductive liquid and wherein the resistance of the compositions are less than the resistance for a bulk conductor when strained as defined by Pouillet's law.
Rebecca Bottiglio, Shanliangzi Liu, Dylan Shah, Lina Mercedes Sanchez Botero
Filed: 30 Dec 22
Utility
CXCR5 Antagonists and Methods of Treating Diseases or Disorders Using Same
11 May 23
The disclosure provides compounds, and compositions comprising such compounds, that can be used to treat CXCR5-expressing cancers, especially angioimmunoblastic T cell lymphoma (AICL) and/or cutaneous T cell lymphoma (CTCL).
Elias Lolis, Francine Foss, Demetrios Braddock, Yulia Surovtseva, Christopher Fanger, Mark Plummer, Denton Hoyer, Elizabeth Spencer
Filed: 30 Mar 21
Utility
Prediction of response to immune-modulatory therapies
9 May 23
The present disclosure provides a method of treating cancer by immune checkpoint blockade, or selecting patients for treatment with immune checkpoint blockers, by detecting tumors with high levels of T-lymphocytes with low levels of activation and proliferation.
David L. Rimm, Kurt Schalper
Filed: 30 Nov 17
Utility
Enhanced chemiluminescent enzyme-linked immunosorbent assay for detection of antibodies against
2 May 23
Identification of immunodominant Babesia microti antigens using genome-wide immunoscreening is described.
Sanjai Kumar, Nitin Verma, Ankit Puri, Peter J. Krause
Filed: 1 Nov 18