Health Sciences Trust

Fund Profile

Fund profile

Tickers

JAFMX, JEHSX, JAFKX

Fund manager

John Hancock Variable Insurance Trust

Total assets

$235.95 mm

Liabilities

$133.26 k

Net assets

$235.81 mm

Number of holdings

176.00

176 Holdings

As of Dec 2024

Security	$Holding	Balance	% of Fund	Category	Position	Country
LLY Eli Lilly and Company	24.15 mm	31.28 k shares	10.24	Common equity	Long	USA
UNH UnitedHealth Group Incorporated	14.67 mm	29.01 k shares	6.22	Common equity	Long	USA
ISRG Intuitive Surgical, Inc.	13.76 mm	26.37 k shares	5.84	Common equity	Long	USA
TMO Thermo Fisher Scientific Inc.	10.87 mm	20.89 k shares	4.61	Common equity	Long	USA
SYK Stryker Corporation	9.90 mm	27.50 k shares	4.20	Common equity	Long	USA
DHR Danaher Corporation	8.87 mm	38.64 k shares	3.76	Common equity	Long	USA
ARGENX SE ADR	8.73 mm	14.19 k shares	3.70	Common equity	Long	Netherlands
MRK Merck & Co., Inc.	6.06 mm	60.93 k shares	2.57	Common equity	Long	USA
BSX Boston Scientific Corporation	5.99 mm	67.03 k shares	2.54	Common equity	Long	USA
VRTX Vertex Pharmaceuticals Incorporated	5.74 mm	14.25 k shares	2.43	Common equity	Long	USA
ALNY Alnylam Pharmaceuticals, Inc.	5.51 mm	23.41 k shares	2.34	Common equity	Long	USA
ASTRAZENECA PLC ADR	4.98 mm	76.02 k shares	2.11	Common equity	Long	UK
ELV Elevance Health Inc.	4.44 mm	12.05 k shares	1.88	Common equity	Long	USA
REGN Regeneron Pharmaceuticals, Inc.	4.35 mm	6.11 k shares	1.85	Common equity	Long	USA
AMGN Amgen Inc.	3.60 mm	13.81 k shares	1.53	Common equity	Long	USA
INSM Insmed Incorporated	3.36 mm	48.72 k shares	1.43	Common equity	Long	USA
Cigna Holding Co	3.15 mm	11.42 k shares	1.34	Common equity	Long	USA
BDX Becton, Dickinson and Company	2.99 mm	13.16 k shares	1.27	Common equity	Long	USA
BPMC Blueprint Medicines Corporation	2.70 mm	30.91 k shares	1.14	Common equity	Long	USA
PEN Penumbra, Inc.	2.62 mm	11.04 k shares	1.11	Common equity	Long	USA
ASND Ascendis Pharma A/S	2.58 mm	18.75 k shares	1.09	Common equity	Long	Denmark
ONC BeiGene, Ltd.	2.49 mm	13.46 k shares	1.05	Common equity	Long	USA
SNY Sanofi	2.44 mm	50.60 k shares	1.03	Common equity	Long	France
UTHR United Therapeutics Corporation	1.80 mm	5.11 k shares	0.76	Common equity	Long	USA
HCA HCA Healthcare, Inc.	1.79 mm	5.97 k shares	0.76	Common equity	Long	USA
SRRK Scholar Rock Holding Corporation	1.74 mm	40.31 k shares	0.74	Common equity	Long	USA
SMMT Summit Therapeutics Inc.	1.68 mm	94.14 k shares	0.71	Common equity	Long	USA
PCVX Vaxcyte, Inc.	1.66 mm	20.22 k shares	0.70	Common equity	Long	USA
MLTX MoonLake Immunotherapeutics	1.60 mm	29.55 k shares	0.68	Common equity	Long	Switzerland
MOH Molina Healthcare, Inc.	1.58 mm	5.42 k shares	0.67	Common equity	Long	USA
NTRA Natera, Inc.	1.57 mm	9.94 k shares	0.67	Common equity	Long	USA
THC Tenet Healthcare Corporation	1.53 mm	12.14 k shares	0.65	Common equity	Long	USA
SONOVA HOLDING AG COMMON STOCK CHF.05	1.48 mm	4.51 k shares	0.63	Common equity	Long	Switzerland
NBIX Neurocrine Biosciences, Inc.	1.41 mm	10.32 k shares	0.60	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	1.40 mm	31.94 k shares	0.59	Common equity	Long	USA
RNA Avidity Biosciences, Inc.	1.34 mm	45.92 k shares	0.57	Common equity	Long	USA
EW Edwards Lifesciences Corporation	1.33 mm	17.99 k shares	0.56	Common equity	Long	USA
BHVN Biohaven Ltd.	1.32 mm	35.42 k shares	0.56	Common equity	Long	USA
CHUGAI PHARMACEUTICAL CO LTD COMMON STOCK	1.30 mm	29.60 k shares	0.55	Common equity	Long	Japan
ACLX Arcellx, Inc.	1.29 mm	16.79 k shares	0.55	Common equity	Long	USA
VRNA Verona Pharma plc	1.28 mm	27.49 k shares	0.54	Common equity	Long	UK
EXAS Exact Sciences Corporation	1.26 mm	22.44 k shares	0.53	Common equity	Long	USA
CRNX Crinetics Pharmaceuticals, Inc.	1.15 mm	22.39 k shares	0.49	Common equity	Long	USA
A Agilent Technologies, Inc.	1.14 mm	8.50 k shares	0.48	Common equity	Long	USA
CNTA Centessa Pharmaceuticals plc	1.12 mm	67.00 k shares	0.48	Common equity	Long	USA
TECH Bio-Techne Corporation	1.07 mm	14.80 k shares	0.45	Common equity	Long	USA
KYMR Kymera Therapeutics, Inc.	1.06 mm	26.35 k shares	0.45	Common equity	Long	USA
SCC GOVERMENT MM GVXX 20301231 00001.0000000000	999.34 k	999.34 k shares	0.42	Short-term investment vehicle	Long	USA
IDXX IDEXX Laboratories, Inc.	965.80 k	2.34 k shares	0.41	Common equity	Long	USA
VERA Vera Therapeutics, Inc.	959.14 k	22.68 k shares	0.41	Common equity	Long	USA
MDGL Madrigal Pharmaceuticals, Inc.	938.98 k	3.04 k shares	0.40	Common equity	Long	USA
ZAI LAB LTD ADR USD.00006	928.10 k	35.44 k shares	0.39	Common equity	Long	China
DGX Quest Diagnostics Incorporated	925.07 k	6.13 k shares	0.39	Common equity	Long	USA
RVTY Revvity, Inc.	880.49 k	7.89 k shares	0.37	Common equity	Long	USA
CAH Cardinal Health, Inc.	829.19 k	7.01 k shares	0.35	Common equity	Long	USA
CNC Centene Corporation	797.11 k	13.16 k shares	0.34	Common equity	Long	USA
DXCM DexCom, Inc.	793.80 k	10.21 k shares	0.34	Common equity	Long	USA
KRYS Krystal Biotech, Inc.	788.16 k	5.03 k shares	0.33	Common equity	Long	USA
OSCR Oscar Health, Inc.	785.50 k	58.45 k shares	0.33	Common equity	Long	USA
PTGX Protagonist Therapeutics, Inc.	785.43 k	20.35 k shares	0.33	Common equity	Long	USA
NVCR NovoCure Limited	764.64 k	25.66 k shares	0.32	Common equity	Long	Jersey
MCK McKesson Corporation	760.83 k	1.34 k shares	0.32	Common equity	Long	USA
Alkermes Plc	759.24 k	26.40 k shares	0.32	Common equity	Long	Ireland
COR Cencora	758.74 k	3.38 k shares	0.32	Common equity	Long	USA
PRCT PROCEPT BioRobotics Corporation	756.16 k	9.39 k shares	0.32	Common equity	Long	USA
HOLX Hologic, Inc.	754.28 k	10.46 k shares	0.32	Common equity	Long	USA
SARTORIUS AG PREFERENCE	740.93 k	3.33 k shares	0.31	Preferred equity	Long	Germany
NVO Novo Nordisk A/S	740.46 k	8.61 k shares	0.31	Common equity	Long	Denmark
INCY Incyte Corporation	739.95 k	10.71 k shares	0.31	Common equity	Long	USA
APGE Apogee Therapeutics, Inc.	720.18 k	15.90 k shares	0.31	Common equity	Long	USA
BTSG BrightSpring Health Services, Inc. Common Stock	703.97 k	41.34 k shares	0.30	Common equity	Long	USA
AGIO Agios Pharmaceuticals, Inc.	684.74 k	20.84 k shares	0.29	Common equity	Long	USA
IMCR Immunocore Holdings plc	667.73 k	22.64 k shares	0.28	Common equity	Long	UK
IONS Ionis Pharmaceuticals, Inc.	658.47 k	18.84 k shares	0.28	Common equity	Long	USA
DNLI Denali Therapeutics Inc.	657.70 k	32.27 k shares	0.28	Common equity	Long	USA
RGEN Repligen Corporation	656.08 k	4.56 k shares	0.28	Common equity	Long	USA
CYTK Cytokinetics, Incorporated	644.02 k	13.69 k shares	0.27	Common equity	Long	USA
MASI Masimo Corporation	596.57 k	3.61 k shares	0.25	Common equity	Long	USA
COO The Cooper Companies, Inc.	582.65 k	6.34 k shares	0.25	Common equity	Long	USA
TEVA PHARMACEUTICAL INDUSTRIES ADR	579.17 k	26.28 k shares	0.25	Common equity	Long	Israel
BEAM Beam Therapeutics Inc.	573.92 k	23.14 k shares	0.24	Common equity	Long	USA
SWTX SpringWorks Therapeutics, Inc.	552.61 k	15.30 k shares	0.23	Common equity	Long	USA
BIIB Biogen Inc.	542.87 k	3.55 k shares	0.23	Common equity	Long	USA
PRAX Praxis Precision Medicines, Inc.	533.49 k	6.93 k shares	0.23	Common equity	Long	USA
AKRO Akero Therapeutics, Inc.	530.22 k	19.06 k shares	0.22	Common equity	Long	USA
RARE Ultragenyx Pharmaceutical Inc.	523.77 k	12.45 k shares	0.22	Common equity	Long	USA
JANX Janux Therapeutics, Inc.	516.66 k	9.65 k shares	0.22	Common equity	Long	USA
BMRN BioMarin Pharmaceutical Inc.	510.66 k	7.77 k shares	0.22	Common equity	Long	USA
WVE Wave Life Sciences Ltd.	493.17 k	39.87 k shares	0.21	Common equity	Long	USA
BNTX BioNTech SE	487.25 k	4.28 k shares	0.21	Common equity	Long	Germany
HUM Humana Inc.	471.65 k	1.86 k shares	0.20	Common equity	Long	USA
NUVL Nuvalent, Inc.	470.85 k	6.02 k shares	0.20	Common equity	Long	USA
ORKA Oruka Therapeutics Inc.	467.32 k	24.10 k shares	0.20	Common equity	Long	USA
ICLR ICON Public Limited Company	461.15 k	2.20 k shares	0.20	Common equity	Long	Ireland
UCB SA COMMON STOCK	458.24 k	2.30 k shares	0.19	Common equity	Long	Belgium
REPL Replimune Group, Inc.	448.42 k	37.03 k shares	0.19	Common equity	Long	USA
LEGN Legend Biotech Corporation	437.50 k	13.45 k shares	0.19	Common equity	Long	USA
CRGX CARGO Therapeutics, Inc. Common Stock	400.62 k	27.78 k shares	0.17	Common equity	Long	USA
IMNM Immunome, Inc.	398.96 k	37.57 k shares	0.17	Common equity	Long	USA
LENZ LENZ Therapeutics, Inc.	397.40 k	13.77 k shares	0.17	Common equity	Long	USA
SLNO Soleno Therapeutics, Inc.	393.31 k	8.75 k shares	0.17	Common equity	Long	USA
TARS Tarsus Pharmaceuticals, Inc.	393.29 k	7.10 k shares	0.17	Common equity	Long	USA
LNTH Lantheus Holdings, Inc.	388.44 k	4.34 k shares	0.16	Common equity	Long	USA
IRON Disc Medicine, Inc.	388.20 k	6.12 k shares	0.16	Common equity	Long	USA
CLDX Celldex Therapeutics, Inc.	378.04 k	14.96 k shares	0.16	Common equity	Long	USA
RYTM Rhythm Pharmaceuticals, Inc.	370.87 k	6.63 k shares	0.16	Common equity	Long	USA
MRUS Merus N.V.	368.65 k	8.77 k shares	0.16	Common equity	Long	Netherlands
ALHC Alignment Healthcare, Inc.	363.11 k	32.28 k shares	0.15	Common equity	Long	USA
GPCR Structure Therapeutics Inc.	362.78 k	13.38 k shares	0.15	Common equity	Long	USA
BRKR Bruker Corporation	362.10 k	6.18 k shares	0.15	Common equity	Long	USA
BCYC Bicycle Therapeutics plc	358.43 k	25.60 k shares	0.15	Common equity	Long	UK
RAPP Rapport Therapeutics, Inc. Common Stock	352.53 k	19.87 k shares	0.15	Common equity	Long	USA
XNCR Xencor, Inc.	351.11 k	15.28 k shares	0.15	Common equity	Long	USA
CGON CG Oncology, Inc. Common stock	300.05 k	10.46 k shares	0.13	Common equity	Long	USA
TXG 10x Genomics, Inc.	296.30 k	20.63 k shares	0.13	Common equity	Long	USA
RCKT Rocket Pharmaceuticals, Inc.	295.83 k	23.54 k shares	0.13	Common equity	Long	USA
VEEV Veeva Systems Inc.	290.15 k	1.38 k shares	0.12	Common equity	Long	USA
DYN Dyne Therapeutics, Inc.	269.08 k	11.42 k shares	0.11	Common equity	Long	USA
IDYA IDEAYA Biosciences, Inc.	268.23 k	10.44 k shares	0.11	Common equity	Long	USA
BCAX Bicara Therapeutics Inc. Common Stock	260.24 k	14.94 k shares	0.11	Common equity	Long	USA
APLS Apellis Pharmaceuticals, Inc.	257.74 k	8.08 k shares	0.11	Common equity	Long	USA
ARVN Arvinas, Inc.	235.45 k	12.28 k shares	0.10	Common equity	Long	USA
IOVA Iovance Biotherapeutics, Inc.	234.48 k	31.69 k shares	0.10	Common equity	Long	USA
IMCR Immunocore Holdings plc	232.14 k	277.00 k principal	0.10	Debt	Long	UK
SYRE Spyre Therapeutics, Inc.	226.28 k	9.72 k shares	0.10	Common equity	Long	USA
ALLO Allogene Therapeutics, Inc.	213.42 k	100.20 k shares	0.09	Common equity	Long	USA
GLUE Monte Rosa Therapeutics, Inc.	207.73 k	29.93 k shares	0.09	Common equity	Long	USA
ORIC ORIC Pharmaceuticals, Inc.	206.83 k	25.63 k shares	0.09	Common equity	Long	USA
PRTA Prothena Corporation plc	203.51 k	14.69 k shares	0.09	Common equity	Long	Ireland
TRDA Entrada Therapeutics, Inc.	201.00 k	11.63 k shares	0.09	Common equity	Long	USA
MBX MBX Biosciences, Inc. Common Stock	196.87 k	10.68 k shares	0.08	Common equity	Long	USA
IMTX Immatics N.V.	192.61 k	27.09 k shares	0.08	Common equity	Long	Germany
PHVS Pharvaris N.V.	191.47 k	9.99 k shares	0.08	Common equity	Long	Netherlands
KOD Kodiak Sciences Inc.	184.08 k	18.50 k shares	0.08	Common equity	Long	USA
GERN Geron Corporation	180.77 k	51.07 k shares	0.08	Common equity	Long	USA
PLRX Pliant Therapeutics, Inc.	180.23 k	13.69 k shares	0.08	Common equity	Long	USA
SEPN Septerna, Inc. Common Stock	173.77 k	7.59 k shares	0.07	Common equity	Long	USA
HLXB Helix Acquisition Corp. II Class A Ordinary Shares	171.13 k	16.30 k shares	0.07	Common equity	Long	Cayman Islands
RLAY Relay Therapeutics, Inc.	165.13 k	40.08 k shares	0.07	Common equity	Long	USA
OCUL Ocular Therapeutix, Inc.	121.27 k	14.20 k shares	0.05	Common equity	Long	USA
SENSORION SA COMMON STOCK EUR.1	120.07 k	182.87 k shares	0.05	Common equity	Long	France
EHC Encompass Health Corporation	120.06 k	1.30 k shares	0.05	Common equity	Long	USA
ANNX Annexon, Inc.	113.42 k	22.11 k shares	0.05	Common equity	Long	USA
IGMS IGM Biosciences, Inc.	108.00 k	17.68 k shares	0.05	Common equity	Long	USA
VRDN Viridian Therapeutics, Inc.	103.52 k	5.40 k shares	0.04	Common equity	Long	USA
VYGR Voyager Therapeutics, Inc.	90.52 k	15.96 k shares	0.04	Common equity	Long	USA
SANA Sana Biotechnology, Inc.	89.28 k	54.77 k shares	0.04	Common equity	Long	USA
EYPT EyePoint Pharmaceuticals, Inc.	87.06 k	11.69 k shares	0.04	Common equity	Long	USA
KROS Keros Therapeutics, Inc.	86.13 k	5.44 k shares	0.04	Common equity	Long	USA
AURA Aura Biosciences, Inc.	85.70 k	10.43 k shares	0.04	Common equity	Long	USA
ANAB AnaptysBio, Inc.	84.74 k	6.40 k shares	0.04	Common equity	Long	USA
LYEL Lyell Immunopharma, Inc.	79.31 k	123.93 k shares	0.03	Common equity	Long	USA
ZNTL Zentalis Pharmaceuticals, Inc.	79.09 k	26.10 k shares	0.03	Common equity	Long	USA
MGNX MacroGenics, Inc.	78.29 k	24.09 k shares	0.03	Common equity	Long	USA
WGS GeneDx Holdings Corp.	70.56 k	918.00 shares	0.03	Common equity	Long	USA
ROWE T PRICE GOV RES FD 20340919 00000.0000000000	67.32 k	67.32 k shares	0.03	Short-term investment vehicle	Long	USA
NxStage Medical, Inc.	66.85 k	36.53 k shares	0.03	Common equity	Long	USA
IMRX Immuneering Corporation	65.29 k	29.68 k shares	0.03	Common equity	Long	USA
URGN UroGen Pharma Ltd.	58.58 k	5.50 k shares	0.02	Common equity	Long	USA
OBIO Orchestra BioMed Holdings, Inc.	53.42 k	13.35 k shares	0.02	Common equity	Long	USA
NGNE Neurogene Inc.	52.58 k	2.30 k shares	0.02	Common equity	Long	USA
THRD Third Harmonic Bio, Inc.	51.04 k	4.96 k shares	0.02	Common equity	Long	USA
CRBP Corbus Pharmaceuticals Holdings, Inc.	50.74 k	4.30 k shares	0.02	Common equity	Long	USA
SAGE Sage Therapeutics, Inc.	48.73 k	8.97 k shares	0.02	Common equity	Long	USA
ANRO Alto Neuroscience, Inc.	48.24 k	11.41 k shares	0.02	Common equity	Long	USA
GBIO Generation Bio Co.	39.95 k	37.69 k shares	0.02	Common equity	Long	USA
KYTX Kyverna Therapeutics, Inc.	33.02 k	8.83 k shares	0.01	Common equity	Long	USA
ALEC Alector, Inc.	22.88 k	12.10 k shares	0.01	Common equity	Long	USA
PRLD Prelude Therapeutics Incorporated	22.22 k	17.43 k shares	0.01	Common equity	Long	USA
CABA Cabaletta Bio, Inc.	22.22 k	9.79 k shares	0.01	Common equity	Long	USA
SPOT Spotify Technology S.A.	19.36 k	1.97 k shares	0.01	Common equity	Long	USA
CLYM Climb Bio, Inc.	16.56 k	9.20 k shares	0.01	Common equity	Long	USA
DAWN Day One Biopharmaceuticals, Inc.	14.46 k	1.14 k shares	0.01	Common equity	Long	USA
WGS GeneDx Holdings Corp.	777.92	4.86 k shares	0.00	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	727.52	4.50 k shares	0.00	Common equity	Long	USA
SLGCW SomaLogic, Inc.	207.05	2.05 k shares	0.00	Common equity	Long	USA