Health Sciences Trust

Fund Profile

Fund profile

Tickers

JAFMX, JEHSX, JAFKX

Fund manager

John Hancock Variable Insurance Trust

Total assets

$268.99 mm

Liabilities

$89.98 k

Net assets

$268.90 mm

Number of holdings

186.00

186 Holdings

As of Sep 2024

Security	$Holding	Balance	% of Fund	Category	Position	Country
LLY Eli Lilly and Company	28.15 mm	31.77 k shares	10.47	Common equity	Long	USA
UNH UnitedHealth Group Incorporated	19.57 mm	33.47 k shares	7.28	Common equity	Long	USA
TMO Thermo Fisher Scientific Inc.	13.44 mm	21.72 k shares	5.00	Common equity	Long	USA
ISRG Intuitive Surgical, Inc.	12.95 mm	26.37 k shares	4.82	Common equity	Long	USA
DHR Danaher Corporation	10.90 mm	39.20 k shares	4.05	Common equity	Long	USA
SYK Stryker Corporation	9.61 mm	26.62 k shares	3.58	Common equity	Long	USA
MRK Merck & Co., Inc.	8.31 mm	73.15 k shares	3.09	Common equity	Long	USA
ELV Elevance Health Inc.	8.01 mm	15.40 k shares	2.98	Common equity	Long	USA
REGN Regeneron Pharmaceuticals, Inc.	7.90 mm	7.51 k shares	2.94	Common equity	Long	USA
ARGX argenx SE	7.60 mm	14.03 k shares	2.83	Common equity	Long	Netherlands
VRTX Vertex Pharmaceuticals Incorporated	6.48 mm	13.93 k shares	2.41	Common equity	Long	USA
ALNY Alnylam Pharmaceuticals, Inc.	6.32 mm	22.98 k shares	2.35	Common equity	Long	USA
AMGN Amgen Inc.	5.96 mm	18.49 k shares	2.22	Common equity	Long	USA
ASTRAZENECA PLC ADR	5.52 mm	70.92 k shares	2.05	Common equity	Long	UK
Cigna Holding Co	4.66 mm	13.44 k shares	1.73	Common equity	Long	USA
BSX Boston Scientific Corporation	4.53 mm	54.07 k shares	1.68	Common equity	Long	USA
INSM Insmed Incorporated	3.32 mm	45.52 k shares	1.24	Common equity	Long	USA
HCA HCA Healthcare, Inc.	3.24 mm	7.97 k shares	1.20	Common equity	Long	USA
MOH Molina Healthcare, Inc.	3.04 mm	8.82 k shares	1.13	Common equity	Long	USA
BDX Becton, Dickinson and Company	3.01 mm	12.49 k shares	1.12	Common equity	Long	USA
NVO Novo Nordisk A/S	2.99 mm	25.09 k shares	1.11	Common equity	Long	Denmark
ONC BeiGene, Ltd.	2.89 mm	12.85 k shares	1.07	Common equity	Long	USA
THC Tenet Healthcare Corporation	2.52 mm	15.16 k shares	0.94	Common equity	Long	USA
ASND Ascendis Pharma A/S	2.34 mm	15.67 k shares	0.87	Common equity	Long	Denmark
BPMC Blueprint Medicines Corporation	2.34 mm	25.27 k shares	0.87	Common equity	Long	USA
PCVX Vaxcyte, Inc.	2.32 mm	20.34 k shares	0.86	Common equity	Long	USA
ROWE T PRICE GOV RES FD 20340919 00000.0000000000	2.29 mm	2.29 mm shares	0.85	Short-term investment vehicle	Long	USA
RNA Avidity Biosciences, Inc.	2.20 mm	47.92 k shares	0.82	Common equity	Long	USA
PEN Penumbra, Inc.	2.09 mm	10.75 k shares	0.78	Common equity	Long	USA
A Agilent Technologies, Inc.	1.86 mm	12.50 k shares	0.69	Common equity	Long	USA
BHVN Biohaven Ltd.	1.63 mm	32.54 k shares	0.60	Common equity	Long	USA
UTHR United Therapeutics Corporation	1.47 mm	4.10 k shares	0.55	Common equity	Long	USA
EXAS Exact Sciences Corporation	1.43 mm	21.04 k shares	0.53	Common equity	Long	USA
NBIX Neurocrine Biosciences, Inc.	1.40 mm	12.19 k shares	0.52	Common equity	Long	USA
SNY Sanofi	1.36 mm	23.54 k shares	0.50	Common equity	Long	France
CHUGAI PHARMACEUTICAL CO LTD COMMON STOCK	1.29 mm	26.60 k shares	0.48	Common equity	Long	Japan
RVMD Revolution Medicines, Inc.	1.27 mm	27.98 k shares	0.47	Common equity	Long	USA
EW Edwards Lifesciences Corporation	1.26 mm	19.05 k shares	0.47	Common equity	Long	USA
SMMT Summit Therapeutics Inc.	1.25 mm	56.98 k shares	0.46	Common equity	Long	USA
MLTX MoonLake Immunotherapeutics	1.23 mm	24.32 k shares	0.46	Common equity	Long	Switzerland
HOLX Hologic, Inc.	1.19 mm	14.56 k shares	0.44	Common equity	Long	USA
TECH Bio-Techne Corporation	1.17 mm	14.60 k shares	0.43	Common equity	Long	USA
ICLR ICON Public Limited Company	1.12 mm	3.90 k shares	0.42	Common equity	Long	Ireland
OSCR Oscar Health, Inc.	1.10 mm	51.68 k shares	0.41	Common equity	Long	USA
ACLX Arcellx, Inc.	1.10 mm	13.12 k shares	0.41	Common equity	Long	USA
SONOVA HOLDING AG COMMON STOCK CHF.05	1.09 mm	3.03 k shares	0.41	Common equity	Long	Switzerland
KYMR Kymera Therapeutics, Inc.	1.06 mm	22.40 k shares	0.39	Common equity	Long	USA
AGIO Agios Pharmaceuticals, Inc.	1.05 mm	23.53 k shares	0.39	Common equity	Long	USA
HUM Humana Inc.	1.03 mm	3.26 k shares	0.38	Common equity	Long	USA
IDXX IDEXX Laboratories, Inc.	1.01 mm	2.00 k shares	0.38	Common equity	Long	USA
RARE Ultragenyx Pharmaceutical Inc.	993.79 k	17.89 k shares	0.37	Common equity	Long	USA
CRNX Crinetics Pharmaceuticals, Inc.	986.38 k	19.30 k shares	0.37	Common equity	Long	USA
CYTK Cytokinetics, Incorporated	981.60 k	18.59 k shares	0.37	Common equity	Long	USA
IONS Ionis Pharmaceuticals, Inc.	958.84 k	23.94 k shares	0.36	Common equity	Long	USA
Madrigal Pharmaceuticals, Inc.	935.68 k	4.41 k shares	0.35	Common equity	Long	USA
NTRA Natera, Inc.	926.74 k	7.30 k shares	0.34	Common equity	Long	USA
RVTY Revvity, Inc.	907.03 k	7.10 k shares	0.34	Common equity	Long	USA
CNTA Centessa Pharmaceuticals plc	905.45 k	56.63 k shares	0.34	Common equity	Long	USA
GPCR Structure Therapeutics Inc.	876.79 k	19.98 k shares	0.33	Common equity	Long	USA
VERA Vera Therapeutics, Inc.	841.17 k	19.03 k shares	0.31	Common equity	Long	USA
DNLI Denali Therapeutics Inc.	828.05 k	28.43 k shares	0.31	Common equity	Long	USA
MCK McKesson Corporation	808.38 k	1.64 k shares	0.30	Common equity	Long	USA
PTGX Protagonist Therapeutics, Inc.	776.39 k	17.25 k shares	0.29	Common equity	Long	USA
KRYS Krystal Biotech, Inc.	737.40 k	4.05 k shares	0.27	Common equity	Long	USA
IMCR Immunocore Holdings plc	735.76 k	23.64 k shares	0.27	Common equity	Long	UK
LEGN Legend Biotech Corporation	722.71 k	14.83 k shares	0.27	Common equity	Long	USA
RGEN Repligen Corporation	719.54 k	4.84 k shares	0.27	Common equity	Long	USA
Alkermes Plc	718.03 k	25.65 k shares	0.27	Common equity	Long	Ireland
LBPH Longboard Pharmaceuticals, Inc.	717.89 k	21.54 k shares	0.27	Common equity	Long	USA
SARTORIUS AG PREFERENCE	699.01 k	2.49 k shares	0.26	Preferred equity	Long	Germany
BIIB Biogen Inc.	688.13 k	3.55 k shares	0.26	Common equity	Long	USA
DGX Quest Diagnostics Incorporated	683.10 k	4.40 k shares	0.25	Common equity	Long	USA
CAH Cardinal Health, Inc.	678.59 k	6.14 k shares	0.25	Common equity	Long	USA
ZAI LAB LTD ADR USD.00006	658.47 k	27.28 k shares	0.24	Common equity	Long	China
PRCT PROCEPT BioRobotics Corporation	656.34 k	8.19 k shares	0.24	Common equity	Long	USA
APGE Apogee Therapeutics, Inc.	648.72 k	11.04 k shares	0.24	Common equity	Long	USA
SWTX SpringWorks Therapeutics, Inc.	635.42 k	19.83 k shares	0.24	Common equity	Long	USA
CNC Centene Corporation	629.72 k	8.37 k shares	0.23	Common equity	Long	USA
TXG 10x Genomics, Inc.	592.36 k	26.23 k shares	0.22	Common equity	Long	USA
LANTHEUS HOLDINGS INC COMMON STOCK USD.01	586.61 k	5.35 k shares	0.22	Common equity	Long	USA
BMRN BioMarin Pharmaceutical Inc.	581.23 k	8.27 k shares	0.22	Common equity	Long	USA
BEAM Beam Therapeutics Inc.	566.98 k	23.14 k shares	0.21	Common equity	Long	USA
VRNA Verona Pharma plc	555.26 k	19.30 k shares	0.21	Common equity	Long	UK
DXCM DexCom, Inc.	553.01 k	8.25 k shares	0.21	Common equity	Long	USA
COR Cencora	542.44 k	2.41 k shares	0.20	Common equity	Long	USA
BCYC Bicycle Therapeutics plc	536.58 k	23.71 k shares	0.20	Common equity	Long	UK
NVCR NovoCure Limited	535.92 k	34.29 k shares	0.20	Common equity	Long	Jersey
CLDX Celldex Therapeutics, Inc.	528.41 k	15.55 k shares	0.20	Common equity	Long	USA
CRGX CARGO Therapeutics, Inc. Common Stock	512.58 k	27.78 k shares	0.19	Common equity	Long	USA
DYN Dyne Therapeutics, Inc.	511.03 k	14.23 k shares	0.19	Common equity	Long	USA
SSC GOVERNMENT MM GVMXX 20301231 00001.0000000000	500.00 k	500.00 k shares	0.19	Short-term investment vehicle	Long	USA
IMNM Immunome, Inc.	496.60 k	33.97 k shares	0.18	Common equity	Long	USA
BTSG BrightSpring Health Services, Inc. Common Stock	458.56 k	31.24 k shares	0.17	Common equity	Long	USA
MRUS Merus N.V.	452.99 k	9.07 k shares	0.17	Common equity	Long	Netherlands
CGON CG Oncology, Inc. Common stock	448.19 k	11.88 k shares	0.17	Common equity	Long	USA
INSP Inspire Medical Systems, Inc.	445.10 k	2.11 k shares	0.17	Common equity	Long	USA
BNTX BioNTech SE	439.45 k	3.70 k shares	0.16	Common equity	Long	Germany
AKRO Akero Therapeutics, Inc.	427.91 k	14.92 k shares	0.16	Common equity	Long	USA
BRKR Bruker Corporation	426.58 k	6.18 k shares	0.16	Common equity	Long	USA
GERN Geron Corporation	425.69 k	93.77 k shares	0.16	Common equity	Long	USA
NUVL Nuvalent, Inc.	420.86 k	4.11 k shares	0.16	Common equity	Long	USA
COO The Cooper Companies, Inc.	408.26 k	3.70 k shares	0.15	Common equity	Long	USA
IMTX Immatics N.V.	403.80 k	35.39 k shares	0.15	Common equity	Long	Germany
PRAX Praxis Precision Medicines, Inc.	398.87 k	6.93 k shares	0.15	Common equity	Long	USA
RCKT Rocket Pharmaceuticals, Inc.	396.66 k	21.48 k shares	0.15	Common equity	Long	USA
XNCR Xencor, Inc.	393.33 k	19.56 k shares	0.15	Common equity	Long	USA
TEMPUS AI INC COMMON STOCK USD.0001	391.05 k	6.91 k shares	0.15	Common equity	Long	USA
SLNO Soleno Therapeutics, Inc.	390.19 k	7.73 k shares	0.15	Common equity	Long	USA
IDYA IDEAYA Biosciences, Inc.	387.67 k	12.24 k shares	0.14	Common equity	Long	USA
RAPP Rapport Therapeutics, Inc. Common Stock	363.93 k	17.77 k shares	0.14	Common equity	Long	USA
INCY Incyte Corporation	337.11 k	5.10 k shares	0.13	Common equity	Long	USA
REPL Replimune Group, Inc.	328.50 k	29.97 k shares	0.12	Common equity	Long	USA
IOVA Iovance Biotherapeutics, Inc.	321.02 k	34.19 k shares	0.12	Common equity	Long	USA
ARVN Arvinas, Inc.	302.51 k	12.28 k shares	0.11	Common equity	Long	USA
SRRK Scholar Rock Holding Corporation	300.70 k	37.54 k shares	0.11	Common equity	Long	USA
IGMS IGM Biosciences, Inc.	292.36 k	17.68 k shares	0.11	Common equity	Long	USA
RLAY Relay Therapeutics, Inc.	283.77 k	40.08 k shares	0.11	Common equity	Long	USA
BCRX BioCryst Pharmaceuticals, Inc.	283.48 k	37.30 k shares	0.11	Common equity	Long	USA
ALLO Allogene Therapeutics, Inc.	280.55 k	100.20 k shares	0.10	Common equity	Long	USA
MBX MBX Biosciences, Inc. Common Stock	277.52 k	10.68 k shares	0.10	Common equity	Long	USA
BCAX Bicara Therapeutics Inc. Common Stock	269.32 k	10.57 k shares	0.10	Common equity	Long	USA
WVE Wave Life Sciences Ltd.	260.58 k	31.78 k shares	0.10	Common equity	Long	USA
PRTA Prothena Corporation plc	257.54 k	15.39 k shares	0.10	Common equity	Long	Ireland
RYTM Rhythm Pharmaceuticals, Inc.	248.28 k	4.74 k shares	0.09	Common equity	Long	USA
ORKA Oruka Therapeutics Inc.	240.59 k	9.82 k shares	0.09	Common equity	Long	USA
IMCR Immunocore Holdings plc	238.81 k	277.00 k principal	0.09	Debt	Long	UK
APLS Apellis Pharmaceuticals, Inc.	232.94 k	8.08 k shares	0.09	Common equity	Long	USA
SANA Sana Biotechnology, Inc.	227.86 k	54.77 k shares	0.08	Common equity	Long	USA
IRON Disc Medicine, Inc.	227.71 k	4.63 k shares	0.08	Common equity	Long	USA
ARDX Ardelyx, Inc.	217.55 k	31.58 k shares	0.08	Common equity	Long	USA
ANAB AnaptysBio, Inc.	214.40 k	6.40 k shares	0.08	Common equity	Long	USA
ORIC ORIC Pharmaceuticals, Inc.	211.15 k	20.60 k shares	0.08	Common equity	Long	USA
PHVS Pharvaris N.V.	192.94 k	10.42 k shares	0.07	Common equity	Long	Netherlands
TRDA Entrada Therapeutics, Inc.	185.77 k	11.63 k shares	0.07	Common equity	Long	USA
NMRA Neumora Therapeutics, Inc. Common Stock	184.94 k	14.00 k shares	0.07	Common equity	Long	USA
SYRE Spyre Therapeutics, Inc.	183.22 k	6.23 k shares	0.07	Common equity	Long	USA
ALHC Alignment Healthcare, Inc.	180.63 k	15.28 k shares	0.07	Common equity	Long	USA
ENOV Enovis Corporation	173.79 k	4.04 k shares	0.06	Common equity	Long	USA
LYEL Lyell Immunopharma, Inc.	171.02 k	123.93 k shares	0.06	Common equity	Long	USA
HLXB Helix Acquisition Corp. II	170.31 k	16.30 k shares	0.06	Common equity	Long	Cayman Islands
GLUE Monte Rosa Therapeutics, Inc.	158.64 k	29.93 k shares	0.06	Common equity	Long	USA
TARS Tarsus Pharmaceuticals, Inc.	155.50 k	4.73 k shares	0.06	Common equity	Long	USA
SENSORION SA COMMON STOCK EUR.1	153.94 k	182.87 k shares	0.06	Common equity	Long	France
PLRX Pliant Therapeutics, Inc.	153.41 k	13.69 k shares	0.06	Common equity	Long	USA
AKESO INC - B COMMON STOCK USD.00001	149.08 k	17.00 k shares	0.06	Common equity	Long	China
ANNX Annexon, Inc.	130.89 k	22.11 k shares	0.05	Common equity	Long	USA
BIOA BioAge Labs, Inc.	128.04 k	6.16 k shares	0.05	Common equity	Long	USA
OCUL Ocular Therapeutix, Inc.	123.54 k	14.20 k shares	0.05	Common equity	Long	USA
JANX Janux Therapeutics, Inc.	113.94 k	2.51 k shares	0.04	Common equity	Long	USA
APLT Applied Therapeutics, Inc.	113.05 k	13.30 k shares	0.04	Common equity	Long	USA
LENZ LENZ Therapeutics, Inc.	110.56 k	4.66 k shares	0.04	Common equity	Long	USA
ANRO Alto Neuroscience, Inc.	105.31 k	9.21 k shares	0.04	Common equity	Long	USA
TVTX Travere Therapeutics, Inc.	103.53 k	7.40 k shares	0.04	Common equity	Long	USA
ZNTL Zentalis Pharmaceuticals, Inc.	96.06 k	26.10 k shares	0.04	Common equity	Long	USA
GOSS Gossamer Bio, Inc.	94.16 k	95.45 k shares	0.04	Common equity	Long	USA
VYGR Voyager Therapeutics, Inc.	93.39 k	15.96 k shares	0.03	Common equity	Long	USA
EYPT EyePoint Pharmaceuticals, Inc.	93.37 k	11.69 k shares	0.03	Common equity	Long	USA
GBIO Generation Bio Co.	93.10 k	37.69 k shares	0.03	Common equity	Long	USA
AURA Aura Biosciences, Inc.	92.90 k	10.43 k shares	0.03	Common equity	Long	USA
SPRY ARS Pharmaceuticals, Inc.	89.90 k	6.20 k shares	0.03	Common equity	Long	USA
CRBP Corbus Pharmaceuticals Holdings, Inc.	88.71 k	4.30 k shares	0.03	Common equity	Long	USA
TERN Terns Pharmaceuticals, Inc.	85.50 k	10.25 k shares	0.03	Common equity	Long	USA
MGNX MacroGenics, Inc.	79.25 k	24.09 k shares	0.03	Common equity	Long	USA
IMRX Immuneering Corporation	73.89 k	29.68 k shares	0.03	Common equity	Long	USA
OBIO Orchestra BioMed Holdings, Inc.	68.64 k	13.35 k shares	0.03	Common equity	Long	USA
AUTL Autolus Therapeutics plc	66.17 k	18.23 k shares	0.02	Common equity	Long	UK
SAGE Sage Therapeutics, Inc.	64.79 k	8.97 k shares	0.02	Common equity	Long	USA
NxStage Medical, Inc.	62.10 k	36.53 k shares	0.02	Common equity	Long	USA
SILENCE THERAPEUTICS PLC ADR GBP.0005	58.18 k	3.20 k shares	0.02	Common equity	Long	UK
ALEC Alector, Inc.	56.40 k	12.10 k shares	0.02	Common equity	Long	USA
PHARMING GROUP NV COMMON STOCK EUR.01	55.49 k	66.46 k shares	0.02	Common equity	Long	Netherlands
BDTX Black Diamond Therapeutics, Inc.	49.16 k	11.30 k shares	0.02	Common equity	Long	USA
RGLS Regulus Therapeutics Inc.	48.98 k	31.20 k shares	0.02	Common equity	Long	USA
CLYM Climb Bio, Inc.	46.83 k	9.20 k shares	0.02	Common equity	Long	USA
CABA Cabaletta Bio, Inc.	46.19 k	9.79 k shares	0.02	Common equity	Long	USA
KYTX Kyverna Therapeutics, Inc.	43.17 k	8.83 k shares	0.02	Common equity	Long	USA
WGS GeneDx Holdings Corp.	38.96 k	918.00 shares	0.01	Common equity	Long	USA
PRLD Prelude Therapeutics Incorporated	36.08 k	17.43 k shares	0.01	Common equity	Long	USA
ABOS Acumen Pharmaceuticals, Inc.	34.10 k	13.75 k shares	0.01	Common equity	Long	USA
CCCC C4 Therapeutics, Inc.	25.65 k	4.50 k shares	0.01	Common equity	Long	USA
DNA Ginkgo Bioworks Holdings, Inc.	16.06 k	1.97 k shares	0.01	Common equity	Long	USA
DAWN Day One Biopharmaceuticals, Inc.	15.89 k	1.14 k shares	0.01	Common equity	Long	USA
RAPT RAPT Therapeutics, Inc.	13.29 k	6.61 k shares	0.00	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	630.28	4.50 k shares	0.00	Common equity	Long	USA
WGS GeneDx Holdings Corp.	358.82	4.86 k shares	0.00	Common equity	Long	USA
SLGCW SomaLogic, Inc.	207.05	2.05 k shares	0.00	Common equity	Long	USA