206 patents
Page 8 of 11
Utility
Multimeric protected fluorescent reagents
28 Sep 20
Multimeric protected fluorescent reagents and their methods of synthesis are provided.
Frank Zheng, Jeremiah Hanes, Gene Shen, Louis Brogley, Stephen Yue, Yuri Lapin, John Lyle, Honey Osuna, Andrei Fedorov, Lubomir Sebo
Filed: 3 Dec 18
Utility
Protected Dye-labeled Reagents
23 Sep 20
Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided.
Lubomir SEBO, Honey OSUNA, Stephen YUE, Yuri LAPIN
Filed: 30 Jan 20
Utility
Methods and Compositions for Generating Asymmetrically-tagged Nucleic Acid Fragments
23 Sep 20
The present disclosure provides improved methods for generating asymmetrically-tagged nucleic acid constructs, compositions comprising such constructs, and kits and systems for generating such constructs.
Joan Wilson
Filed: 26 Jan 20
Utility
De novo diploid genome assembly and haplotype sequence reconstruction
21 Sep 20
Exemplary embodiments provide methods and systems for diploid genome assembly and haplotype sequence reconstruction.
Chen-Shan Chin, Paul Peluso, David Rank
Filed: 22 May 16
Utility
Labeled nucleotide analogs, reaction mixtures, and methods and systems for sequencing
21 Sep 20
Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided.
Lubomir Sebo, Gene Shen, Stephen Yue, Honey Osuna, Yuri Lapin, Louis Brogley, Andrei Fedorov
Filed: 20 Nov 16
Utility
Hierarchical genome assembly method using single long insert library
14 Sep 20
The present invention is generally directed to a hierarchical genome assembly process for producing high-quality de novo genome assemblies.
Chen-Shan Chin, Patrick Marks, David Alexander, Aaron Klammer, Stephen W Turner
Filed: 11 Jul 13
Utility
Arrays of integrated analytical devices and methods for production
7 Sep 20
Arrays of integrated analytical devices and their methods for production are provided.
Ravi Saxena, Michael Tzu Ru, Takashi Whitney Orimoto, Annette Grot, Mathieu Foquet, Hou-Pu Chou
Filed: 2 Jun 19
Utility
Recombinant Polymerases for Incorporation of Protein Shield Nucleotide Analogs
2 Sep 20
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification.
Satwik Kamtekar, Erik Miller
Filed: 8 Mar 20
Utility
Method for Increasing Polymerase Processivity
19 Aug 20
The present invention provides methods for increasing polymerase processivity.
John G.K. Williams
Filed: 22 Jan 20
Utility
Modular nucleotide compositions and uses therefor
17 Aug 20
Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide types through a swappable and preferably non-covalent linkage component.
Jonas Korlach, Jeffrey Wegener
Filed: 14 Nov 18
Utility
Heteroarylcyanine Dyes
12 Aug 20
The present invention provides heteroaryl functionalized cyanine dyes including a reactive functional moiety, or which are conjugated to a carrier molecule.
Stephen Yue, Gene SHEN, Wei-Chuan (David) SUN
Filed: 18 Sep 19
Utility
Methods and compositions for loading of polymerase complexes
3 Aug 20
The present disclosure provides methods, compositions, and systems for distributing polymerase compositions into array regions.
Sassan Sheikholeslami, Michael Hunkapiller, Natasha Popovich, Lei Sun, Erik Miller, Satwik Kamtekar
Filed: 16 Nov 16
Utility
Systems and Methods for Graph Based Mapping of Nucleic Acid Fragments
29 Jul 20
Technical solutions for mapping long nucleic acid sequence reads to a target sequence are provided.
Ivan Sovic, James Drake
Filed: 23 Jan 20
Utility
Integrated analytical system and method
27 Jul 20
An analytical assembly within a unified device structure for integration into an analytical system.
Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
Filed: 15 Apr 19
Utility
Cyanine Dyes
22 Jul 20
The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes.
Stephen Yue, Gene SHEN, Wei-Chuan (David) SUN
Filed: 19 Aug 19
Utility
Polymerases for nucleotide analogue incorporation
20 Jul 20
Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided.
David R. Rank, Paul S. Peluso, David K. Hanzel, Geoff Otto, Thang Pham, Fred Christians, Arekadiusz Bibillo, Insil Park, Sonya Clark, John Lyle
Filed: 11 Feb 18
Utility
Bis-biotinylation Tags
15 Jul 20
Multi-biotinylated reactants are provided which can be used in divalent complexes for various applications such as colocalization, labeling, immobilization, and purification.
Gene Shen, Natasha Popovich, Erik Miller, Satwik Kamtekar, Keith Bjornson, Jeremiah Hanes, Stephen Yue, Lubomir Sebo, Zhong Wang
Filed: 8 Dec 19
Utility
Methods and compositions for delivery of molecules and complexes to reaction sites
13 Jul 20
The present invention provides methods, compositions, and systems for distributing molecules and complexes into reaction sites.
Satwik Kamtekar, Keith Bjornson, Leewin Chern, Steven Lin
Filed: 20 Jul 17
Utility
Integrated Illumination of Optical Analytical Devices
1 Jul 20
Optical analytical devices and their methods of use are provided.
Paul LUNDQUIST, Stephen TURNER
Filed: 23 Feb 20
Utility
Analytic device comprising a nanohole extending through an opaque mask layer and into a waveguide cladding
29 Jun 20
This invention provides substrates for use in various applications, including single-molecule analytical reactions.
Cheng Frank Zhong, Paul Lundquist, Mathieu Foquet, Jonas Korlach, Hovig Bayandorian
Filed: 27 Feb 19