112 patents
Page 4 of 6
Utility
Methods, systems, and reagents for direct RNA sequencing
23 Mar 21
Provided are compositions comprising recombinant polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for sequencing RNA or RNA/DNA templates.
Satwik Kamtekar, Jeremiah Hanes
Filed: 15 Mar 19
Utility
Systems, devices, and methods for improved optical waveguide transmission and alignment
16 Mar 21
Provided herein are systems, devices, and methods for improved optical waveguide transmission and alignment in an analytical system.
Alexey Kuritsyn, Mark McDonald, Aaron Rulison, Russell Berman
Filed: 3 Nov 18
Utility
Real-time redox sequencing chips
9 Mar 21
Real time redox sequencing methods, devices, and systems are described.
Jonas Korlach, Stephen Turner, Lei Sun
Filed: 18 Mar 19
Utility
Nucleic acid sequencing with nanoscale electrode pairs
2 Mar 21
Sequencing methods, devices, and systems are described.
Stephen Turner, Jeremiah Hanes, Keith Bjornson
Filed: 8 Dec 17
Utility
Loading extended polymerase-nucleic acid complexes
2 Mar 21
Compositions, methods and systems are provided for the loading of extended polymerase-nucleic acid complexes onto substrates.
Thang Pham, Arunashree Bhamidipati, Kevin Travers, Eric Olivares, Tyson A. Clark, Jonas Korlach
Filed: 13 Jun 18
Utility
Methods and compositions for isolating asymmetric nucleic acid complexes
16 Feb 21
The present disclosure provides improved methods for isolating asymmetrically-primed and/or asymmetrically-tagged nucleic acid complexes that find use in downstream analytical analyses, including sequence analysis.
Lei Sun, Sassan Sheikholeslami, Natasha Popovich, David Christopher Scherer
Filed: 16 Jul 18
Utility
Method for analyzing luminescent species
26 Jan 21
The application relates to methods of analyzing luminescent species.
Jeremy Gray, Lei Sun
Filed: 27 Nov 18
Utility
Methods and compositions for single molecule composition loading
12 Jan 21
The present invention provides methods, compositions, and systems for distributing single polymerase molecules into array regions.
Lei Sun, Natasha Popovich, Gene Shen, Thang Pham, Stephen Turner
Filed: 21 Nov 19
Utility
Compositions and methods for enrichment of nucleic acids
7 Dec 20
Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis.
Yu-Chih Tsai, Igor Vilfan, Khai Luong
Filed: 27 Aug 19
Utility
Arrays of integrated analytical devices
7 Dec 20
Arrays of integrated analytical devices and their methods for production are provided.
Annette Grot, Ravi Saxena, Paul Lundquist
Filed: 13 Mar 19
Utility
Loading nucleic acids onto substrates
26 Oct 20
Methods, compositions, and systems for distributing nucleic acids into array regions are provided.
Lei Sun, Jaime Juan Benitez-Marzan, Natasha Popovich, Sassan Sheikholeslami, Steven Lin, Aparna Vedula
Filed: 16 Nov 16
Utility
Recombinant polymerases with increased phototolerance
26 Oct 20
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing.
Satwik Kamtekar, Arek Bibillo, Keith Bjornson, Fred Christians, Colleen Cutcliffe, Jeremiah Hanes, Lei Jia, Walter Lee, Erik Miller, Pranav Patel
Filed: 6 Jun 19
Utility
Protected fluorescent reagent compounds
12 Oct 20
Protected fluorescent reagent compounds and their methods of synthesis are provided.
Lubomir Sebo, Jeremiah Hanes, Gene Shen, Louis Brogley, Stephen Yue, Frank Zheng, Yuri Lapin, John Lyle, Honey Osuna, Andrei Fedorov
Filed: 29 Apr 18
Utility
Identifying organisms in a sample using sequencing kinetic signatures
5 Oct 20
Methods, compositions, and systems are provided for characterization of modified nucleic acids.
Benjamin Flusberg, Stephen Turner, Jon Sorenson, Kevin Travers, Cheryl Heiner
Filed: 27 Sep 16
Utility
Multimeric protected fluorescent reagents
28 Sep 20
Multimeric protected fluorescent reagents and their methods of synthesis are provided.
Frank Zheng, Jeremiah Hanes, Gene Shen, Louis Brogley, Stephen Yue, Yuri Lapin, John Lyle, Honey Osuna, Andrei Fedorov, Lubomir Sebo
Filed: 3 Dec 18
Utility
De novo diploid genome assembly and haplotype sequence reconstruction
21 Sep 20
Exemplary embodiments provide methods and systems for diploid genome assembly and haplotype sequence reconstruction.
Chen-Shan Chin, Paul Peluso, David Rank
Filed: 22 May 16
Utility
Labeled nucleotide analogs, reaction mixtures, and methods and systems for sequencing
21 Sep 20
Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided.
Lubomir Sebo, Gene Shen, Stephen Yue, Honey Osuna, Yuri Lapin, Louis Brogley, Andrei Fedorov
Filed: 20 Nov 16
Utility
Hierarchical genome assembly method using single long insert library
14 Sep 20
The present invention is generally directed to a hierarchical genome assembly process for producing high-quality de novo genome assemblies.
Chen-Shan Chin, Patrick Marks, David Alexander, Aaron Klammer, Stephen W Turner
Filed: 11 Jul 13
Utility
Arrays of integrated analytical devices and methods for production
7 Sep 20
Arrays of integrated analytical devices and their methods for production are provided.
Ravi Saxena, Michael Tzu Ru, Takashi Whitney Orimoto, Annette Grot, Mathieu Foquet, Hou-Pu Chou
Filed: 2 Jun 19
Utility
Modular nucleotide compositions and uses therefor
17 Aug 20
Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide types through a swappable and preferably non-covalent linkage component.
Jonas Korlach, Jeffrey Wegener
Filed: 14 Nov 18