112 patents
Page 5 of 6
Utility
Methods and compositions for loading of polymerase complexes
3 Aug 20
The present disclosure provides methods, compositions, and systems for distributing polymerase compositions into array regions.
Sassan Sheikholeslami, Michael Hunkapiller, Natasha Popovich, Lei Sun, Erik Miller, Satwik Kamtekar
Filed: 16 Nov 16
Utility
Integrated analytical system and method
27 Jul 20
An analytical assembly within a unified device structure for integration into an analytical system.
Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
Filed: 15 Apr 19
Utility
Polymerases for nucleotide analogue incorporation
20 Jul 20
Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided.
David R. Rank, Paul S. Peluso, David K. Hanzel, Geoff Otto, Thang Pham, Fred Christians, Arekadiusz Bibillo, Insil Park, Sonya Clark, John Lyle
Filed: 11 Feb 18
Utility
Methods and compositions for delivery of molecules and complexes to reaction sites
13 Jul 20
The present invention provides methods, compositions, and systems for distributing molecules and complexes into reaction sites.
Satwik Kamtekar, Keith Bjornson, Leewin Chern, Steven Lin
Filed: 20 Jul 17
Utility
Analytic device comprising a nanohole extending through an opaque mask layer and into a waveguide cladding
29 Jun 20
This invention provides substrates for use in various applications, including single-molecule analytical reactions.
Cheng Frank Zhong, Paul Lundquist, Mathieu Foquet, Jonas Korlach, Hovig Bayandorian
Filed: 27 Feb 19
Utility
Modified nucleotide reagents
8 Jun 20
Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided.
Gene Shen, Stephen Yue, Lubomir Sebo, Louis Brogley
Filed: 18 May 17
Utility
Protected dye-labeled reagents
1 Jun 20
Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided.
Lubomir Sebo, Honey Osuna, Stephen Yue, Yuri Lapin
Filed: 20 Nov 16
Utility
Methods and compositions for generating asymmetrically-tagged nucleic acid fragments
25 May 20
The present disclosure provides improved methods for generating asymmetrically-tagged nucleic acid constructs, compositions comprising such constructs, and kits and systems for generating such constructs.
Joan Wilson
Filed: 8 May 19
Utility
Modified biotin-binding proteins for immobilization
18 May 20
Compositions comprising covalently modified and mutated biotin-binding proteins, particularly biotin-binding proteins having a negative charge at physiological pH, are provided.
Satwik Kamtekar, Lubomir Sebo, Leewin Chern, Thomas Linsky, Jeremiah Hanes, Erik Miller, Ying Yang, Stephen Yue
Filed: 20 Dec 18
Utility
Articles having localized molecules disposed thereon and methods of producing same
18 May 20
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate.
David R. Rank, Jeffrey Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ronald L. Cicero
Filed: 26 Jun 14
Utility
Compositions and methods for selection of nucleic acids
4 May 20
Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence analysis.
Thang Tat Pham, Yu-Chih Tsai, Jonas Korlach, Tyson A. Clark, Stephen Turner
Filed: 15 Nov 16
Utility
Integrated analytical system and method
4 May 20
An analytical assembly within a unified device structure for integration into an analytical system.
Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
Filed: 16 Oct 17
Utility
Recombinant polymerases for incorporation of protein shield nucleotide analogs
20 Apr 20
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification.
Satwik Kamtekar, Erik Miller
Filed: 13 Dec 17
Utility
Arrays of optical devices comprising integrated bandpass filters and methods of production
20 Apr 20
Arrays of integrated optical devices and their methods for production are provided.
Ravi Saxena, Annette Grot, Nicolaas Tack, Pilar Gonzalez, Bert Du Bois, Simone Severi
Filed: 27 Oct 16
Utility
Sequencing reactions with monovalent cations for pulse width control
6 Apr 20
Compositions, kits, methods and systems for single molecule nucleotide sequencing comprising producing polymerase reactions having monovalent cations that control the median pulse width for incorporated nucleotides are disclosed.
Andrei Fedorov, John Lyle, Keith Bjornson, Jeremiah Hanes
Filed: 11 Dec 18
Utility
Methods and compositions for sequencing modified nucleic acids
16 Mar 20
Methods, compositions, and systems are provided for characterization of modified nucleic acids.
Jonas Korlach, Stephen Turner, Tyson A. Clark
Filed: 18 Jan 18
Utility
Method for nucleic acid sequencing
2 Mar 20
The present invention provides novel compositions, methods and apparatus for DNA sequencing that can be performed, e.g., in a two-electrode chamber.
John G. K. Williams
Filed: 9 May 18
Utility
Illumination of optical analytical devices
2 Mar 20
Optical analytical devices and their methods of use are provided.
Annette Grot, Shang Wang, Hans Callebaut, Paul Lundquist, Stephen Turner
Filed: 8 Jul 18
Utility
Fret-labeled compounds and uses therefor
24 Feb 20
FRET-labeled compounds are provided for use in analytical reactions.
Xiangxu Kong, Gene Shen
Filed: 29 Jul 18
Utility
Integrated illumination of optical analytical devices
24 Feb 20
Optical analytical devices and their methods of use are provided.
Paul Lundquist, Stephen Turner
Filed: 2 Dec 18