1919 patents
Page 12 of 96
Utility
CorrectedEngineered Incoherent Feed Forward Loop and Uses Thereof
25 May 23
The present disclosure, at least in part, relates to an engineered incoherent feed forward loop (iFFL) comprising a first transcription unit encoding an endoribonuclease and a second transcription unit encoding an output molecule and an endoribonuclease target site located in the 5′ UTR of the output molecule coding sequence.
Ron Weiss, Ross D. Jones, Breanna E. DiAndreth, Domitilla Del Vecchio, Yili Qian
Filed: 20 Jan 21
Utility
Mitigation of Communication Signal Interference Using Adaptive Transmit Power
25 May 23
In some embodiments, a method for mitigating interference in a channel having multiple users includes: transmitting, by a transmitter, a signal of interest (SOI) to a sequential interference cancellation (SIC) receiver at a transmit power; determining a packet drop rate as seen by the receiver; and decreasing the transmit power in response to determining the packet drop rate exceeds a predetermined maximum packet drop rate.
Rachel E. Learned
Filed: 21 May 20
Utility
Polarization-Separated, Phase-Shifted Interferometer
25 May 23
A polarization-separated, phase-shifted interferometer can generate interferograms without moving parts.
Noah GILBERT, Joshua BROWN
Filed: 10 Jan 22
Utility
Engineered Muscle Targeting Compositions
25 May 23
Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs.
Pardis SABETI, Mohammadsharif TABEBORDBAR, Simon YE, Kim LAGERBORG, Alexandra STANTON, Amy WAGERS
Filed: 22 Jul 21
Utility
Methods for Generating Engineered Memory-like NK Cells and Compositions Thereof
18 May 23
The present disclosure relates to cytokine-induced memory-like NK cells expressing a chimeric antigen receptor polypeptide that binds to a neoepitope of mutant nucleophosmin (NPM1c) in complex with, or presented by, a class I major histocompatibility complex (MHC class I) protein, or cells expressing such compounds, and their use in methods for treating, or ameliorating one or more symptoms of, cancer.
Jianzhu Chen, Jerome Ritz, Rizwan Romee, Han Dong, Guozhu Xie, James Dongjoo Ham
Filed: 10 Mar 21
Utility
Small Molecule Binders of the Oncogenic Fusion Transcription Factor PAX3-FOXO1
18 May 23
The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety.
Angela Nicole Koehler, Shelby Doyle, Becky Leifer, Matthew Henley, Beat W. Schaefer, Marco Wachtel
Filed: 16 Sep 22
Utility
Foam Reduction And/or Prevention Methods and Associated Systems and Articles
18 May 23
Foam mitigation using a variety of articles, systems, and methods is generally described.
Kripa K. Varanasi, Leonid Rapoport
Filed: 19 Oct 22
Utility
Lipid Compositions for Delivery of Sting Agonist Compounds and Uses Thereof
18 May 23
The present disclosure provides lipid compositions comprising lipid particles (e.g., lipid nanodiscs), wherein the lipid particles (e.g., lipid nanodiscs) comprise a STING agonist amphiphile conjugate, a phospholipid and a PEG-lipid.
Darrell J. IRVINE, Eric DANE, Masanori OKANIWA
Filed: 20 Apr 21
Utility
Methods of Functionality Screening Biological Sequence Fragments
18 May 23
The invention relates, in part, to methods of accurately and reliably detecting biological sequences corresponding to a particular function.
Kevin Michael Esvelt, Dana Gretton
Filed: 23 Jan 21
Utility
Biodegradable Sustainable Polyesters
18 May 23
Disclosed is a copolymer comprising a hydroxyacid, wherein the copolymer is biodegradable with a decomposition temperature is substantially higher than its melting temperature.
Kristala L. Jones Prather, Desiree Plata, Bradley D. Olsen, Wontae Joo, Sarah Av-Ron, K’yal Rasean Bannister, Omar Tantawi
Filed: 8 Nov 22
Utility
Sequencing-based Population Scale Screening
18 May 23
Provided herein are methods and kits for parallel detection one or more target sequences across multiple samples, comprising separating a set of samples into one or more pooled sets, wherein each sample may comprise an initial amplicon comprising one or more target sequences and at least one barcode; conducting an amplification reaction on the one or more pooled sets to further amplify the amplicons, and optionally further adding an additional barcode to the amplicon; sequencing the amplicons; identifying individual samples from the pooled sample set that are positive for the one or more target sequences based on sequencing of the amplicons, wherein identification is based, at least in part, on detection of the unique combination of barcodes.
Feng Zhang, Jonathan Schmid-Burgk, David Li
Filed: 2 Apr 21
Utility
SARS-COV2 Spike Protein Binding Peptides
18 May 23
The disclosure provides peptides that are useful for the prevention of infection of coronaviruses, especially SARS-CoV-2.
Bradley L. Pentelute, Genwei Zhang, Sebastian Pomplun, Alexander R. Loftis, Andrei Loas
Filed: 19 Mar 21
Utility
System and Method for Analyzing and Steering Use of Third-party Libraries
18 May 23
A system for analysis and steering use of online libraries, contains program source code comprising a plurality of modules, at least one third party library, and a processor and a memory configured to store non-transitory instructions that, when executed by the processor, run a module recontextualization application.
Martin C. Rinard, Nikolaos Vasilakis
Filed: 16 Nov 22
Utility
Composite Feature Engineering
18 May 23
A domain of an input dataset is identified and one or more archived domain knowledge features corresponding to the identified domain are identified.
Dakuo Wang, Udayan Khurana, Chuang Gan, Gregory Bramble, Abel Valente, Arunima Chaudhary, Carolina Maria Spina, Micah Smith
Filed: 14 Nov 21
Utility
Boiling Assisted Channel Templating for Adsorbent Coating Fabrication
11 May 23
A simplified method of making an adsorbent layer can permit design and analysis of sorption systems having improved performance can include generation of one dimensional channels.
Evelyn Wang, Cody Jacobucci, Xiangyu LI, Bachir EL FIL
Filed: 8 Nov 22
Utility
Dopamine D2 Receptor Ligands
11 May 23
The present invention relates to novel dopamine D2 receptor ligands.
Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Edward Scolnick, Michelle Palmer, Luka Dordevic, Michael C. Lewis, Jennifer Q. Pan, Yan-Ling Zhang, Qihong Xu
Filed: 7 Oct 22
Utility
Human Gut Microbiome-derived Biosynthetic Enzymes for Production of Fatty Acid Amides
11 May 23
Disclosed herein, in some embodiments, are vectors encoding biosynthetic enzymes from gut microbiome-derived bacterium (e.g., Clostridia enzymes), engineered cells comprising the vectors, and methods of using biosynthetic enzymes from gut microbiome-derived bacterium (e.g., Clostridia enzymes) to produce fatty acid amides.
Christopher A. Voigt, Fang-Yuan Chang
Filed: 12 Jul 22
Utility
Precision Delivery of Multi-scale Payloads to Tissue-specific Targets In Plants
11 May 23
The invention provides a silk-based biomaterial designed to fabricate a microneedle-like device with controlled degradation rate in planta via tuning material composition and methods of manufacture thereof.
Benedetto MARELLI, Yunteng CAO
Filed: 16 Apr 21
Utility
Passive Quench Protection Techniques for Non-insulated Superconducting Magnets
11 May 23
According to some aspects, techniques are described for designing non-insulated (NI) high temperature superconductor (HTS) magnets that mitigate problems that may arise during quench initiation and propagation.
Brian LABOMBARD, Krishna Kiran Kumar UPPALAPATI
Filed: 25 Mar 21
Utility
Transdermal Optogenetic Peripheral Nerve Stimulation
11 May 23
A nerve in a mammal is optogenetically transduced, wherein the nerve is susceptible to stimulus by selective application of transdermal light, and a light source is applied to dermis of the mammal at or proximate to the optogenetically transduced nerve, to thereby stimulate the nerve.
Hugh M. Herr, Benjamin Maimon, Anthony Zorzos
Filed: 25 Oct 22