1919 patents
Page 14 of 96
Utility
Amino Acid-, Peptide- and Polypeptide-lipids, Isomers, Compositions, and Uses Thereof
20 Apr 23
Yizhou Dong, Kevin Thomas Love, Robert S. Langer, Daniel Griffith Anderson, Delai Chen, Yi Chen, Arturo Jose Vegas, Akinleye C. Alabi, Yunlong Zhang
Filed: 23 Aug 22
Utility
Qty FC Fusion Receptor Proteins
20 Apr 23
The present invention is directed to QTY CCR9 and CXCR2 variant Fc receptor fusion proteins, methods for the preparation thereof and methods of use thereof.
Shuguang Zhang, David Jin, Rui Qing, Uwe Sleytr
Filed: 29 Jul 22
Utility
Multiplexed Detection with Isotope-coded Reporters
13 Apr 23
Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (LC MS/MS).
Gabriel A. Kwong, Sangeeta N. Bhatia
Filed: 8 Dec 22
Utility
Fabrication of Three-Dimensional Kirigami Structures with Tunable Properties
13 Apr 23
A method of forming a structural honeycomb includes cutting and folding a substrate sheet according to predetermined cutting and folding patterns and fold angles that cause the sheet to form a honeycomb having cells that each have at least one face abutting, or nearly abutting, the face of another cell.
Samuel Eli Calisch, Neil A. Gershenfeld
Filed: 2 Sep 22
Utility
Heme-binding Small Peptide
13 Apr 23
The disclosure provides heme binding peptides and their use for treating disorders that can benefit from sequestering free heme.
Graham C. Walker, Siva Sankari Iyer Mani Sankaran, Vigneshbabu Musuri Periasamy
Filed: 12 Oct 22
Utility
Single-molecule Protein and Peptide Sequencing
6 Apr 23
The present description provides methods, assays and reagents for linearly expanding a peptide.
Daniel Masao Estandian, Edward Stuart Boyden, Jacob Joshua Lee Rodriguez
Filed: 21 Sep 22
Utility
Combination Therapies and Methods of Use Thereof for Treating Cancer
6 Apr 23
Pharmaceutical compositions including an effective amount of an antiandrogen or androgen antagonist in combination with a Plk inhibitor and methods of use thereof for treating cancer are disclosed.
Michael B. Yaffe, Jesse C. Patterson
Filed: 9 Jun 22
Utility
Transferable Ultra-thin Substrates and Related Techniques
6 Apr 23
A device, comprising: a flexible carrier; a release layer that is formed on the flexible carrier; a releasable substrate formed over the release layer; and a semiconductor structure that is formed over the releasable substrate.
Vladimir Bulovic, Mayuran Saravanapavanantham, Jeremiah Mwaura
Filed: 5 Oct 22
Utility
Engineered Alum-binding SARS-CoV-2 Immunogens
6 Apr 23
Compositions are disclosed that include alum and a SARS-CoV-2 Spike (S) glycoprotein variant covalently bound to the alum via at least one linker having 2-12 phosphoserine residues, where the S glycoprotein variant includes a receptor binding domain (RBD) having a mutation of at least one amino acid residue in an angiotensin-converting enzyme 2 (ACE2) receptor binding motif (RBM) relative to a wild-type RBD, where the residue is (i) hydrophobic; and (ii) within an aggregation-prone region of about 3-15 amino acid residues, and the mutation is a substitution of the hydrophobic residue with a different amino acid residue; as are compositions and vaccines including the compositions, and methods for their use.
Kristen Alexandra Rodrigues, Sergio A. Rodriguez Aponte, Neil Dalvie, Darrell Irvine, J. Christopher Love
Filed: 29 Jul 22
Utility
Novel Crispr Enzymes and Systems
6 Apr 23
Embodiments disclosed herein are directed to engineered CRISPR-Cas effector proteins that comprise at least one modification compared to an unmodified CRISPR-Cas effector protein that enhances binding of the of the CRISPR complex to the binding site and/or alters editing preference as compared to wild type.
Feng Zhang, David Arthur Scott, Winston Xia Yan, Sourav Choudhury, Matthias Heidenreich
Filed: 11 May 22
Utility
Fabrication-Free Microfluidic Device for Scalable, High-Volume Bacterial Electroporation
6 Apr 23
A disposable, fabrication-free, high-volume electroporation device may process cell samples of large volume without compromising transformation efficiency and cell viability, while precipitously reducing the entire processing time and effort.
Po-Hsun Huang, Cullen Richard Buie, Sijie Chen
Filed: 27 Sep 22
Utility
Antibody-free Rapid Detection of SARS-COV-2 Proteins Using Corona Phase Molecular Recognition (Cophmore)
6 Apr 23
Corona phase molecular recognition (CoPhMoRe) that enables the molecular recognition of SARS-CoV-2 viral proteins without the need for antibody or enzymatic receptor incorporation.
Sooyeon Cho, Michael Strano, Xiaojia Jin, Xun Gong, Sungyun Yang, Jianqiao Cui
Filed: 5 Aug 22
Utility
Engineered 3D-Printed Artificial Axons
6 Apr 23
Materials and methods for cell-mimetics having mechanical properties of biological neural axons are provided.
Daniela Espinosa-Hoyos, Anna E. Jagielska, Huifeng Du, Nicholas X. Fang, Krystyn J. Van Vliet
Filed: 7 Dec 22
Utility
Synergistic Combination of Alum and Non-Liposome, Non-Micelle Particle Vaccine Adjuvants
6 Apr 23
Compositions are disclosed that include alum and a non-liposome, non-micelle particle, where the particle comprises a lipid, a sterol, a saponin, and an optional additional non-alum adjuvant, wherein the particle is optionally bound to the alum, and the use of the compositions as vaccine adjuvants and methods for eliciting immune responses.
Darrell Irvine, Kristen Alexandra Rodrigues
Filed: 29 Jul 22
Utility
Protection of Next-Generation Probiotics during Processing
6 Apr 23
Prokaryotic cells having a metal-phenolic network coating are disclosed, as are compositions including such cells, methods for their use, and methods for producing such cells.
Chelsea Catania, Ariel Furst, Gang Fan, Pris Wasuwanich
Filed: 5 Aug 22
Utility
an Implantable Medical Device
30 Mar 23
An implantable medical device having a soft tissue interfacing surface comprises at least one soft actuatable capsule having a soft tissue interfacing deflectable membrane configured for cyclical deflection upon actuation of the capsule to modulate the biomechanics of the soft tissue interface during use.
Ellen ROCHE, Eimear DOLAN, Garry DUFFY, Sandra ROTHENBUCHER, William WHYTE, Claudia VARELA, Scott ROBINSON, Keegan MENDEZ
Filed: 29 Jun 20
Utility
Ex Vivo Tissue Explant and Graft Platform and Uses Thereof
30 Mar 23
An ex vivo tissue composition comprising an isolated tissue explant and tissue graft is provided.
Carlo Giovanni Traverso, Yunhua Shi, Vance Soares, Daniel Reker, Robert S. Langer
Filed: 6 May 22
Utility
Partitioned Superconducting Cable
30 Mar 23
Described is a cable comprising a plurality of high temperature superconductor (HTS) components, a plurality of electrically conductive segments extending along a length of the cable, each of the plurality of electrically conductive segments comprising one of the plurality of HTS components, and an electrically insulating material arranged between adjacent ones of the plurality of electrically conductive segments.
Alexey RADOVINSKY, Charlie SANABRIA, Christopher CRAIGHILL, Krishna Kiran Kumar UPPALAPATI, Alexander CREELY, Daniel BRUNNER
Filed: 4 Mar 21
Utility
Synthetic Tissue Barriers and Uses Thereof
30 Mar 23
The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject.
Carlo Giovanni Traverso, Ameya R. Kirtane, Junwei Li, Thomas Wang, James Byrne, Alexis Jones
Filed: 10 Dec 20
Utility
Emergency Shutdown of A No-Insulation Magnet
30 Mar 23
Structures and methods enable emergency or rapid shutdown of an energized no-insulation (NI) superconducting magnet, without damage due to thermal effects of a quench.
Alexey RADOVINSKY, Krishna Kiran Kumar UPPALAPATI
Filed: 25 Mar 21