Health Sciences Fund

Fund Profile

Fund profile

Fund manager

John Hancock Funds II

Total assets

$95.04 mm

Liabilities

$512.09 k

Net assets

$94.53 mm

Number of holdings

169.00

169 Holdings

As of Feb 2025

Security	$Holding	Balance	% of Fund	Category	Position	Country
LLY Eli Lilly and Company	10.58 mm	11.49 k shares	11.19	Common equity	Long	USA
ISRG Intuitive Surgical, Inc.	5.90 mm	10.29 k shares	6.24	Common equity	Long	USA
UNH UnitedHealth Group Incorporated	5.18 mm	10.90 k shares	5.48	Common equity	Long	USA
TMO Thermo Fisher Scientific Inc.	4.45 mm	8.41 k shares	4.71	Common equity	Long	USA
SYK Stryker Corporation	4.20 mm	10.89 k shares	4.45	Common equity	Long	USA
ARGENX SE ADR	3.48 mm	5.57 k shares	3.68	Common equity	Long	Netherlands
VRTX Vertex Pharmaceuticals Incorporated	3.00 mm	6.25 k shares	3.17	Common equity	Long	USA
BSX Boston Scientific Corporation	2.96 mm	28.57 k shares	3.14	Common equity	Long	USA
DHR Danaher Corporation	2.71 mm	13.05 k shares	2.87	Common equity	Long	USA
ALNY Alnylam Pharmaceuticals, Inc.	2.30 mm	9.33 k shares	2.44	Common equity	Long	USA
ASTRAZENECA PLC ADR	2.18 mm	28.60 k shares	2.31	Common equity	Long	UK
ELV Elevance Health Inc.	1.75 mm	4.40 k shares	1.85	Common equity	Long	USA
REGN Regeneron Pharmaceuticals, Inc.	1.59 mm	2.28 k shares	1.69	Common equity	Long	USA
INSM Insmed Incorporated	1.56 mm	19.10 k shares	1.65	Common equity	Long	USA
BEIGENE LTD ADR USD.0001	1.54 mm	5.65 k shares	1.63	Common equity	Long	USA
MRK Merck & Co., Inc.	1.51 mm	16.34 k shares	1.59	Common equity	Long	USA
AMGN Amgen Inc.	1.42 mm	4.60 k shares	1.50	Common equity	Long	USA
Cigna Holding Co	1.36 mm	4.40 k shares	1.44	Common equity	Long	USA
PEN Penumbra, Inc.	1.31 mm	4.59 k shares	1.39	Common equity	Long	USA
BPMC Blueprint Medicines Corporation	1.15 mm	11.90 k shares	1.22	Common equity	Long	USA
ASND Ascendis Pharma A/S	1.01 mm	6.47 k shares	1.07	Common equity	Long	Denmark
SMMT Summit Therapeutics Inc.	964.53 k	46.62 k shares	1.02	Common equity	Long	USA
SANOFI SA ADR	960.91 k	17.64 k shares	1.02	Common equity	Long	France
BDX Becton, Dickinson and Company	877.09 k	3.89 k shares	0.93	Common equity	Long	USA
CHUGAI PHARMACEUTICAL CO LTD COMMON STOCK	869.01 k	17.30 k shares	0.92	Common equity	Long	Japan
VRNA Verona Pharma plc	779.37 k	11.19 k shares	0.82	Common equity	Long	UK
HCA HCA Healthcare, Inc.	709.70 k	2.32 k shares	0.75	Common equity	Long	USA
SONOVA HOLDING AG COMMON STOCK CHF.05	708.37 k	2.20 k shares	0.75	Common equity	Long	Switzerland
ROCHE HOLDING AG COMMON STOCK	679.05 k	2.04 k shares	0.72	Common equity	Long	Switzerland
GILD Gilead Sciences, Inc.	649.28 k	5.68 k shares	0.69	Common equity	Long	USA
NTRA Natera, Inc.	645.85 k	4.15 k shares	0.68	Common equity	Long	USA
SRRK Scholar Rock Holding Corporation	623.84 k	16.07 k shares	0.66	Common equity	Long	USA
MOH Molina Healthcare, Inc.	608.86 k	2.02 k shares	0.64	Common equity	Long	USA
THC Tenet Healthcare Corporation	601.68 k	4.75 k shares	0.64	Common equity	Long	USA
RNA Avidity Biosciences, Inc.	572.97 k	18.70 k shares	0.61	Common equity	Long	USA
NBIX Neurocrine Biosciences, Inc.	557.27 k	4.69 k shares	0.59	Common equity	Long	USA
PCVX Vaxcyte, Inc.	536.11 k	7.34 k shares	0.57	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	529.78 k	13.00 k shares	0.56	Common equity	Long	USA
DGX Quest Diagnostics Incorporated	528.56 k	3.06 k shares	0.56	Common equity	Long	USA
ZAI LAB LTD ADR USD.00006	523.41 k	15.11 k shares	0.55	Common equity	Long	China
IDXX IDEXX Laboratories, Inc.	517.10 k	1.18 k shares	0.55	Common equity	Long	USA
SARTORIUS AG PREFERENCE	504.94 k	2.02 k shares	0.53	Preferred equity	Long	Germany
BHVN Biohaven Ltd.	497.95 k	13.39 k shares	0.53	Common equity	Long	USA
UTHR United Therapeutics Corporation	496.72 k	1.55 k shares	0.53	Common equity	Long	USA
AKRO Akero Therapeutics, Inc.	469.00 k	9.55 k shares	0.50	Common equity	Long	USA
MLTX MoonLake Immunotherapeutics	463.20 k	11.09 k shares	0.49	Common equity	Long	Switzerland
EXAS Exact Sciences Corporation	427.97 k	9.03 k shares	0.45	Common equity	Long	USA
ACLX Arcellx, Inc.	416.14 k	6.42 k shares	0.44	Common equity	Long	USA
CNTA Centessa Pharmaceuticals plc	412.43 k	26.52 k shares	0.44	Common equity	Long	USA
CAH Cardinal Health, Inc.	405.27 k	3.13 k shares	0.43	Common equity	Long	USA
CNC Centene Corporation	385.83 k	6.63 k shares	0.41	Common equity	Long	USA
RVTY Revvity, Inc.	363.03 k	3.24 k shares	0.38	Common equity	Long	USA
KRYS Krystal Biotech, Inc.	360.29 k	2.01 k shares	0.38	Common equity	Long	USA
A Agilent Technologies, Inc.	356.90 k	2.79 k shares	0.38	Common equity	Long	USA
CVS CVS Health Corporation	353.18 k	5.37 k shares	0.37	Common equity	Long	USA
Alkermes Plc	349.82 k	10.19 k shares	0.37	Common equity	Long	Ireland
MDGL Madrigal Pharmaceuticals, Inc.	348.10 k	1.02 k shares	0.37	Common equity	Long	USA
TECH Bio-Techne Corporation	345.37 k	5.59 k shares	0.37	Common equity	Long	USA
RARE Ultragenyx Pharmaceutical Inc.	327.39 k	7.63 k shares	0.35	Common equity	Long	USA
MASI Masimo Corporation	319.40 k	1.69 k shares	0.34	Common equity	Long	USA
VEEV Veeva Systems Inc.	317.83 k	1.42 k shares	0.34	Common equity	Long	USA
DXCM DexCom, Inc.	315.48 k	3.57 k shares	0.33	Common equity	Long	USA
SWTX SpringWorks Therapeutics, Inc.	314.79 k	5.45 k shares	0.33	Common equity	Long	USA
COR Cencora	310.84 k	1.23 k shares	0.33	Common equity	Long	USA
AGIO Agios Pharmaceuticals, Inc.	307.71 k	8.66 k shares	0.33	Common equity	Long	USA
PTGX Protagonist Therapeutics, Inc.	300.91 k	8.01 k shares	0.32	Common equity	Long	USA
KYMR Kymera Therapeutics, Inc.	295.91 k	9.44 k shares	0.31	Common equity	Long	USA
OSCR Oscar Health, Inc.	289.94 k	19.85 k shares	0.31	Common equity	Long	USA
MCKESSON CORP COMMON STOCK USD.01	289.40 k	452.00 shares	0.31	Common equity	Long	USA
BTSG BrightSpring Health Services, Inc. Common Stock	288.00 k	14.94 k shares	0.30	Common equity	Long	USA
RGEN Repligen Corporation	285.23 k	1.79 k shares	0.30	Common equity	Long	USA
VERA Vera Therapeutics, Inc.	281.52 k	9.41 k shares	0.30	Common equity	Long	USA
CRNX Crinetics Pharmaceuticals, Inc.	274.50 k	7.67 k shares	0.29	Common equity	Long	USA
BEAM Beam Therapeutics Inc.	250.97 k	9.53 k shares	0.27	Common equity	Long	USA
INCY Incyte Corporation	240.93 k	3.28 k shares	0.25	Common equity	Long	USA
IMCR Immunocore Holdings plc	237.52 k	8.09 k shares	0.25	Common equity	Long	UK
PRCT PROCEPT BioRobotics Corporation	235.81 k	3.67 k shares	0.25	Common equity	Long	USA
DNLI Denali Therapeutics Inc.	233.03 k	14.07 k shares	0.25	Common equity	Long	USA
IMCR Immunocore Holdings plc	231.51 k	276.00 k principal	0.24	Debt	Long	UK
COO The Cooper Companies, Inc.	227.40 k	2.52 k shares	0.24	Common equity	Long	USA
UCB SA COMMON STOCK	203.89 k	1.08 k shares	0.22	Common equity	Long	Belgium
EW Edwards Lifesciences Corporation	184.14 k	2.57 k shares	0.19	Common equity	Long	USA
IMNM Immunome, Inc.	179.98 k	19.15 k shares	0.19	Common equity	Long	USA
HELIX ACQUISITION CORP II COMMON STOCK USD.0001	179.24 k	16.22 k shares	0.19	Common equity	Long	Cayman Islands
BIIB Biogen Inc.	178.72 k	1.27 k shares	0.19	Common equity	Long	USA
REPL Replimune Group, Inc.	177.13 k	13.97 k shares	0.19	Common equity	Long	USA
LEGN Legend Biotech Corporation	174.24 k	4.98 k shares	0.18	Common equity	Long	USA
LNTH Lantheus Holdings, Inc.	168.88 k	1.80 k shares	0.18	Common equity	Long	USA
ALHC Alignment Healthcare, Inc.	164.29 k	10.47 k shares	0.17	Common equity	Long	USA
CYTK Cytokinetics, Incorporated	162.20 k	3.53 k shares	0.17	Common equity	Long	USA
APGE Apogee Therapeutics, Inc.	157.80 k	5.02 k shares	0.17	Common equity	Long	USA
NUVL Nuvalent, Inc.	156.48 k	2.09 k shares	0.17	Common equity	Long	USA
IONS Ionis Pharmaceuticals, Inc.	152.54 k	4.60 k shares	0.16	Common equity	Long	USA
IRON Disc Medicine, Inc.	146.97 k	2.62 k shares	0.16	Common equity	Long	USA
JANX Janux Therapeutics, Inc.	127.32 k	3.87 k shares	0.13	Common equity	Long	USA
MTSR Metsera, Inc.	116.96 k	4.72 k shares	0.12	Common equity	Long	USA
MRUS Merus N.V.	116.17 k	2.47 k shares	0.12	Common equity	Long	Netherlands
ICLR ICON Public Limited Company	115.91 k	610.00 shares	0.12	Common equity	Long	Ireland
BCYC Bicycle Therapeutics plc	115.76 k	10.55 k shares	0.12	Common equity	Long	UK
WVE Wave Life Sciences Ltd.	114.13 k	10.80 k shares	0.12	Common equity	Long	USA
RYTM Rhythm Pharmaceuticals, Inc.	113.88 k	2.07 k shares	0.12	Common equity	Long	USA
TARS Tarsus Pharmaceuticals, Inc.	111.64 k	2.51 k shares	0.12	Common equity	Long	USA
CLDX Celldex Therapeutics, Inc.	107.48 k	5.23 k shares	0.11	Common equity	Long	USA
CGON CG Oncology, Inc. Common stock	99.69 k	3.86 k shares	0.11	Common equity	Long	USA
SENSORION SA COMMON STOCK EUR.1	97.32 k	155.87 k shares	0.10	Common equity	Long	France
WGS GeneDx Holdings Corp.	91.95 k	894.00 shares	0.10	Common equity	Long	USA
PRAX Praxis Precision Medicines, Inc.	91.40 k	2.37 k shares	0.10	Common equity	Long	USA
XNCR Xencor, Inc.	89.93 k	5.86 k shares	0.10	Common equity	Long	USA
BCAX Bicara Therapeutics Inc. Common Stock	86.93 k	6.54 k shares	0.09	Common equity	Long	USA
MBX MBX Biosciences, Inc. Common Stock	86.77 k	9.04 k shares	0.09	Common equity	Long	USA
RCKT Rocket Pharmaceuticals, Inc.	85.97 k	9.10 k shares	0.09	Common equity	Long	USA
SLNO Soleno Therapeutics, Inc.	85.58 k	1.75 k shares	0.09	Common equity	Long	USA
SION Sionna Therapeutics, Inc.	81.31 k	5.91 k shares	0.09	Common equity	Long	USA
ORIC ORIC Pharmaceuticals, Inc.	79.00 k	9.84 k shares	0.08	Common equity	Long	USA
ARVN Arvinas, Inc.	77.49 k	4.38 k shares	0.08	Common equity	Long	USA
PRTA Prothena Corporation plc	77.28 k	4.89 k shares	0.08	Common equity	Long	Ireland
NVCR NovoCure Limited	77.14 k	4.05 k shares	0.08	Common equity	Long	Jersey
BNTX BioNTech SE	76.22 k	675.00 shares	0.08	Common equity	Long	Germany
PHVS Pharvaris N.V.	75.60 k	4.76 k shares	0.08	Common equity	Long	Netherlands
GPCR Structure Therapeutics Inc.	73.36 k	3.09 k shares	0.08	Common equity	Long	USA
EWTX Edgewise Therapeutics, Inc.	73.28 k	2.80 k shares	0.08	Common equity	Long	USA
BBNX Beta Bionics, Inc.	70.31 k	3.35 k shares	0.07	Common equity	Long	USA
EHC Encompass Health Corporation	69.70 k	696.00 shares	0.07	Common equity	Long	USA
RAPP Rapport Therapeutics, Inc. Common Stock	64.26 k	6.41 k shares	0.07	Common equity	Long	USA
ALLO Allogene Therapeutics, Inc.	64.06 k	32.85 k shares	0.07	Common equity	Long	USA
GLUE Monte Rosa Therapeutics, Inc.	63.05 k	11.46 k shares	0.07	Common equity	Long	USA
SYRE Spyre Therapeutics, Inc.	61.09 k	3.10 k shares	0.06	Common equity	Long	USA
SANA Sana Biotechnology, Inc.	57.87 k	22.17 k shares	0.06	Common equity	Long	USA
IOVA Iovance Biotherapeutics, Inc.	56.43 k	13.33 k shares	0.06	Common equity	Long	USA
LENZ LENZ Therapeutics, Inc.	55.43 k	2.54 k shares	0.06	Common equity	Long	USA
AURA Aura Biosciences, Inc.	55.23 k	7.37 k shares	0.06	Common equity	Long	USA
TXG 10x Genomics, Inc.	54.44 k	5.09 k shares	0.06	Common equity	Long	USA
VRDN Viridian Therapeutics, Inc.	53.90 k	3.47 k shares	0.06	Common equity	Long	USA
RLAY Relay Therapeutics, Inc.	51.60 k	15.13 k shares	0.05	Common equity	Long	USA
HIMS Hims & Hers Health, Inc.	50.19 k	1.11 k shares	0.05	Common equity	Long	USA
IDYA IDEAYA Biosciences, Inc.	50.15 k	2.44 k shares	0.05	Common equity	Long	USA
EYPT EyePoint Pharmaceuticals, Inc.	49.75 k	7.93 k shares	0.05	Common equity	Long	USA
ORKA Oruka Therapeutics, Inc.	47.47 k	4.68 k shares	0.05	Common equity	Long	USA
LYEL Lyell Immunopharma, Inc.	46.31 k	65.15 k shares	0.05	Common equity	Long	USA
HRTX Heron Therapeutics, Inc.	45.70 k	18.50 k shares	0.05	Common equity	Long	USA
URGN UroGen Pharma Ltd.	44.46 k	4.70 k shares	0.05	Common equity	Long	USA
VYGR Voyager Therapeutics, Inc.	42.75 k	10.48 k shares	0.05	Common equity	Long	USA
TRDA Entrada Therapeutics, Inc.	42.59 k	3.57 k shares	0.05	Common equity	Long	USA
OCUL Ocular Therapeutix, Inc.	41.46 k	5.81 k shares	0.04	Common equity	Long	USA
SEPN Septerna, Inc.	40.00 k	6.18 k shares	0.04	Common equity	Long	USA
KOD Kodiak Sciences Inc.	39.30 k	9.56 k shares	0.04	Common equity	Long	USA
OBIO Orchestra BioMed Holdings, Inc.	37.99 k	8.10 k shares	0.04	Common equity	Long	USA
APLS Apellis Pharmaceuticals, Inc.	37.10 k	1.48 k shares	0.04	Common equity	Long	USA
NxStage Medical, Inc.	36.74 k	25.34 k shares	0.04	Common equity	Long	USA
CGEM Cullinan Oncology, Inc.	36.10 k	4.25 k shares	0.04	Common equity	Long	USA
NGNE Neurogene Inc.	35.38 k	2.00 k shares	0.04	Common equity	Long	USA
ANNX Annexon, Inc.	33.63 k	12.74 k shares	0.04	Common equity	Long	USA
IMRX Immuneering Corporation	33.62 k	20.37 k shares	0.04	Common equity	Long	USA
ANAB AnaptysBio, Inc.	32.95 k	1.96 k shares	0.03	Common equity	Long	USA
DYN Dyne Therapeutics, Inc.	32.27 k	2.37 k shares	0.03	Common equity	Long	USA
MDWD MediWound Ltd.	31.11 k	1.87 k shares	0.03	Common equity	Long	Israel
GBIO Generation Bio Co.	26.44 k	45.59 k shares	0.03	Common equity	Long	USA
KYTX Kyverna Therapeutics, Inc.	25.53 k	8.99 k shares	0.03	Common equity	Long	USA
ALEC Alector, Inc.	24.89 k	15.18 k shares	0.03	Common equity	Long	USA
CABA Cabaletta Bio, Inc.	18.77 k	10.40 k shares	0.02	Common equity	Long	USA
DNA Ginkgo Bioworks Holdings, Inc.	18.76 k	2.28 k shares	0.02	Common equity	Long	USA
ENTA Enanta Pharmaceuticals, Inc.	18.67 k	2.40 k shares	0.02	Common equity	Long	USA
CRGX CARGO Therapeutics, Inc. Common Stock	17.10 k	4.55 k shares	0.02	Common equity	Long	USA
PRLD Prelude Therapeutics Incorporated	13.05 k	17.19 k shares	0.01	Common equity	Long	USA
CLYM Climb Bio, Inc.	11.46 k	7.90 k shares	0.01	Common equity	Long	USA
WGS GeneDx Holdings Corp.	2.00 k	7.15 k shares	0.00	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	561.06	6.52 k shares	0.00	Common equity	Long	USA
SLGCW SomaLogic, Inc.	292.90	2.90 k shares	0.00	Common equity	Long	USA
ROWE T PRICE GOV RES FD 20340919 00000.0000000000	100.00	100.00 shares	0.00	Short-term investment vehicle	Long	USA