Health Sciences Fund

Fund Profile

Fund profile

Fund manager

John Hancock Funds II

Total assets

$227.21 mm

Liabilities

$94.80 k

Net assets

$227.11 mm

Number of holdings

186.00

186 Holdings

As of Nov 2024

Security	$Holding	Balance	% of Fund	Category	Position	Country
LLY Eli Lilly and Company	21.28 mm	26.76 k shares	9.37	Common equity	Long	USA
UNH UnitedHealth Group Incorporated	19.23 mm	31.51 k shares	8.47	Common equity	Long	USA
ISRG Intuitive Surgical, Inc.	12.32 mm	22.72 k shares	5.42	Common equity	Long	USA
TMO Thermo Fisher Scientific Inc.	9.56 mm	18.05 k shares	4.21	Common equity	Long	USA
SYK Stryker Corporation	9.31 mm	23.75 k shares	4.10	Common equity	Long	USA
DHR Danaher Corporation	8.02 mm	33.46 k shares	3.53	Common equity	Long	USA
ARGX argenx SE	7.63 mm	12.38 k shares	3.36	Common equity	Long	Netherlands
VRTX Vertex Pharmaceuticals Incorporated	5.67 mm	12.11 k shares	2.50	Common equity	Long	USA
MRK Merck & Co., Inc.	5.55 mm	54.59 k shares	2.44	Common equity	Long	USA
BSX Boston Scientific Corporation	5.24 mm	57.85 k shares	2.31	Common equity	Long	USA
ALNY Alnylam Pharmaceuticals, Inc.	5.05 mm	19.96 k shares	2.22	Common equity	Long	USA
ELV Elevance Health Inc.	4.78 mm	11.75 k shares	2.10	Common equity	Long	USA
ASTRAZENECA PLC ADR	4.44 mm	65.68 k shares	1.96	Common equity	Long	UK
REGN Regeneron Pharmaceuticals, Inc.	4.07 mm	5.42 k shares	1.79	Common equity	Long	USA
AMGN Amgen Inc.	3.97 mm	14.04 k shares	1.75	Common equity	Long	USA
Cigna Holding Co	3.91 mm	11.58 k shares	1.72	Common equity	Long	USA
INSM Insmed Incorporated	3.11 mm	41.35 k shares	1.37	Common equity	Long	USA
BPMC Blueprint Medicines Corporation	2.65 mm	27.51 k shares	1.17	Common equity	Long	USA
ONC BeiGene, Ltd.	2.55 mm	11.88 k shares	1.12	Common equity	Long	USA
BDX Becton, Dickinson and Company	2.46 mm	11.07 k shares	1.08	Common equity	Long	USA
PEN Penumbra, Inc.	2.34 mm	9.58 k shares	1.03	Common equity	Long	USA
ASND Ascendis Pharma A/S	2.11 mm	15.48 k shares	0.93	Common equity	Long	Denmark
RNA Avidity Biosciences, Inc.	1.83 mm	42.61 k shares	0.81	Common equity	Long	USA
SNY Sanofi	1.80 mm	37.11 k shares	0.79	Common equity	Long	France
PCVX Vaxcyte, Inc.	1.76 mm	18.66 k shares	0.77	Common equity	Long	USA
HCA HCA Healthcare, Inc.	1.76 mm	5.38 k shares	0.77	Common equity	Long	USA
UTHR United Therapeutics Corporation	1.66 mm	4.48 k shares	0.73	Common equity	Long	USA
THC Tenet Healthcare Corporation	1.63 mm	11.44 k shares	0.72	Common equity	Long	USA
MOH Molina Healthcare, Inc.	1.54 mm	5.18 k shares	0.68	Common equity	Long	USA
NVO Novo Nordisk A/S	1.53 mm	14.36 k shares	0.68	Common equity	Long	Denmark
RVMD Revolution Medicines, Inc.	1.51 mm	26.08 k shares	0.66	Common equity	Long	USA
BHVN Biohaven Ltd.	1.44 mm	31.40 k shares	0.64	Common equity	Long	USA
SMMT Summit Therapeutics Inc.	1.44 mm	78.19 k shares	0.64	Common equity	Long	USA
NTRA Natera, Inc.	1.41 mm	8.41 k shares	0.62	Common equity	Long	USA
AGIO Agios Pharmaceuticals, Inc.	1.33 mm	22.36 k shares	0.58	Common equity	Long	USA
SSC GOVERNMENT MM GVMXX 20301231 00001.0000000000	1.32 mm	1.32 mm shares	0.58	Short-term investment vehicle	Long	USA
SRRK Scholar Rock Holding Corporation	1.31 mm	32.75 k shares	0.58	Common equity	Long	USA
MLTX MoonLake Immunotherapeutics	1.29 mm	23.66 k shares	0.57	Common equity	Long	Switzerland
ACLX Arcellx, Inc.	1.26 mm	14.36 k shares	0.56	Common equity	Long	USA
EXAS Exact Sciences Corporation	1.19 mm	19.21 k shares	0.53	Common equity	Long	USA
SONOVA HOLDING AG COMMON STOCK CHF.05	1.16 mm	3.39 k shares	0.51	Common equity	Long	Switzerland
NBIX Neurocrine Biosciences, Inc.	1.14 mm	9.01 k shares	0.50	Common equity	Long	USA
A Agilent Technologies, Inc.	1.14 mm	8.27 k shares	0.50	Common equity	Long	USA
CRNX Crinetics Pharmaceuticals, Inc.	1.12 mm	19.61 k shares	0.49	Common equity	Long	USA
CHUGAI PHARMACEUTICAL CO LTD COMMON STOCK	1.10 mm	25.10 k shares	0.49	Common equity	Long	Japan
KYMR Kymera Therapeutics, Inc.	993.03 k	21.20 k shares	0.44	Common equity	Long	USA
VERA Vera Therapeutics, Inc.	971.92 k	19.54 k shares	0.43	Common equity	Long	USA
TECH Bio-Techne Corporation	971.39 k	12.89 k shares	0.43	Common equity	Long	USA
CNTA Centessa Pharmaceuticals plc	959.81 k	53.59 k shares	0.42	Common equity	Long	USA
Madrigal Pharmaceuticals, Inc.	933.37 k	2.84 k shares	0.41	Common equity	Long	USA
OSCR Oscar Health, Inc.	911.96 k	52.62 k shares	0.40	Common equity	Long	USA
EW Edwards Lifesciences Corporation	906.36 k	12.70 k shares	0.40	Common equity	Long	USA
ZAI LAB LTD ADR USD.00006	904.65 k	31.36 k shares	0.40	Common equity	Long	China
HOLX Hologic, Inc.	903.12 k	11.36 k shares	0.40	Common equity	Long	USA
CYTK Cytokinetics, Incorporated	851.75 k	16.42 k shares	0.38	Common equity	Long	USA
IDXX IDEXX Laboratories, Inc.	827.05 k	1.96 k shares	0.36	Common equity	Long	USA
DGX Quest Diagnostics Incorporated	824.36 k	5.07 k shares	0.36	Common equity	Long	USA
VRNA Verona Pharma plc	819.23 k	20.67 k shares	0.36	Common equity	Long	UK
RVTY Revvity, Inc.	790.56 k	6.81 k shares	0.35	Common equity	Long	USA
CAH Cardinal Health, Inc.	749.82 k	6.13 k shares	0.33	Common equity	Long	USA
PTGX Protagonist Therapeutics, Inc.	746.26 k	17.04 k shares	0.33	Common equity	Long	USA
COR Cencora	742.58 k	2.95 k shares	0.33	Common equity	Long	USA
HUM Humana Inc.	727.02 k	2.45 k shares	0.32	Common equity	Long	USA
PRCT PROCEPT BioRobotics Corporation	722.56 k	7.56 k shares	0.32	Common equity	Long	USA
KRYS Krystal Biotech, Inc.	718.21 k	3.64 k shares	0.32	Common equity	Long	USA
MCK McKesson Corporation	698.26 k	1.11 k shares	0.31	Common equity	Long	USA
INCY Incyte Corporation	685.63 k	9.19 k shares	0.30	Common equity	Long	USA
DNLI Denali Therapeutics Inc.	682.85 k	27.31 k shares	0.30	Common equity	Long	USA
BTSG BrightSpring Health Services, Inc. Common Stock	671.39 k	34.79 k shares	0.30	Common equity	Long	USA
RGEN Repligen Corporation	645.06 k	4.29 k shares	0.28	Common equity	Long	USA
CNC Centene Corporation	637.14 k	10.62 k shares	0.28	Common equity	Long	USA
SWTX SpringWorks Therapeutics, Inc.	625.31 k	15.08 k shares	0.28	Common equity	Long	USA
Alkermes Plc	618.97 k	21.33 k shares	0.27	Common equity	Long	Ireland
IMCR Immunocore Holdings plc	618.23 k	18.88 k shares	0.27	Common equity	Long	UK
RARE Ultragenyx Pharmaceutical Inc.	606.38 k	12.73 k shares	0.27	Common equity	Long	USA
IONS Ionis Pharmaceuticals, Inc.	585.58 k	16.39 k shares	0.26	Common equity	Long	USA
SARTORIUS AG PREFERENCE	543.77 k	2.36 k shares	0.24	Preferred equity	Long	Germany
DXCM DexCom, Inc.	543.59 k	6.97 k shares	0.24	Common equity	Long	USA
NVCR NovoCure Limited	539.16 k	26.90 k shares	0.24	Common equity	Long	Jersey
COO The Cooper Companies, Inc.	534.94 k	5.12 k shares	0.24	Common equity	Long	USA
AKRO Akero Therapeutics, Inc.	532.35 k	16.58 k shares	0.23	Common equity	Long	USA
LEGN Legend Biotech Corporation	525.41 k	12.49 k shares	0.23	Common equity	Long	USA
BEAM Beam Therapeutics Inc.	523.29 k	19.12 k shares	0.23	Common equity	Long	USA
WVE Wave Life Sciences Ltd.	514.00 k	34.04 k shares	0.23	Common equity	Long	USA
BNTX BioNTech SE	497.12 k	4.20 k shares	0.22	Common equity	Long	Germany
ICLR ICON Public Limited Company	488.41 k	2.32 k shares	0.22	Common equity	Long	Ireland
PRAX Praxis Precision Medicines, Inc.	487.99 k	6.09 k shares	0.21	Common equity	Long	USA
BCYC Bicycle Therapeutics plc	471.55 k	23.12 k shares	0.21	Common equity	Long	UK
NUVL Nuvalent, Inc.	468.80 k	4.85 k shares	0.21	Common equity	Long	USA
BMRN BioMarin Pharmaceutical Inc.	466.24 k	7.06 k shares	0.21	Common equity	Long	USA
IMNM Immunome, Inc.	465.24 k	34.34 k shares	0.20	Common equity	Long	USA
BIIB Biogen Inc.	464.86 k	2.89 k shares	0.20	Common equity	Long	USA
APGE Apogee Therapeutics, Inc.	453.71 k	10.05 k shares	0.20	Common equity	Long	USA
REPL Replimune Group, Inc.	450.79 k	32.02 k shares	0.20	Common equity	Long	USA
SLNO Soleno Therapeutics, Inc.	448.46 k	8.51 k shares	0.20	Common equity	Long	USA
TEMPUS AI INC COMMON STOCK USD.0001	446.96 k	7.14 k shares	0.20	Common equity	Long	USA
CRGX CARGO Therapeutics, Inc. Common Stock	438.70 k	24.13 k shares	0.19	Common equity	Long	USA
LENZ LENZ Therapeutics, Inc.	427.20 k	12.00 k shares	0.19	Common equity	Long	USA
XNCR Xencor, Inc.	410.57 k	16.04 k shares	0.18	Common equity	Long	USA
GLUE Monte Rosa Therapeutics, Inc.	392.56 k	37.89 k shares	0.17	Common equity	Long	USA
GPCR Structure Therapeutics Inc.	392.20 k	11.83 k shares	0.17	Common equity	Long	USA
LANTHEUS HOLDINGS INC COMMON STOCK USD.01	387.52 k	4.34 k shares	0.17	Common equity	Long	USA
KROS Keros Therapeutics, Inc.	372.54 k	6.45 k shares	0.16	Common equity	Long	USA
RAPP Rapport Therapeutics, Inc. Common Stock	369.39 k	16.17 k shares	0.16	Common equity	Long	USA
RYTM Rhythm Pharmaceuticals, Inc.	361.20 k	5.82 k shares	0.16	Common equity	Long	USA
JANX Janux Therapeutics, Inc.	357.07 k	7.90 k shares	0.16	Common equity	Long	USA
IRON Disc Medicine, Inc.	353.92 k	5.58 k shares	0.16	Common equity	Long	USA
ALHC Alignment Healthcare, Inc.	353.41 k	28.03 k shares	0.16	Common equity	Long	USA
DYN Dyne Therapeutics, Inc.	352.02 k	11.50 k shares	0.15	Common equity	Long	USA
CLDX Celldex Therapeutics, Inc.	347.58 k	12.67 k shares	0.15	Common equity	Long	USA
MRUS Merus N.V.	345.13 k	7.70 k shares	0.15	Common equity	Long	Netherlands
TXG 10x Genomics, Inc.	315.57 k	19.85 k shares	0.14	Common equity	Long	USA
BRKR Bruker Corporation	295.26 k	5.10 k shares	0.13	Common equity	Long	USA
TARS Tarsus Pharmaceuticals, Inc.	289.10 k	5.51 k shares	0.13	Common equity	Long	USA
RCKT Rocket Pharmaceuticals, Inc.	282.26 k	19.61 k shares	0.12	Common equity	Long	USA
UCB SA COMMON STOCK	281.80 k	1.44 k shares	0.12	Common equity	Long	Belgium
CGON CG Oncology, Inc. Common stock	277.69 k	7.99 k shares	0.12	Common equity	Long	USA
ROWE T PRICE GOV RES FD 20340919 00000.0000000000	274.49 k	274.49 k shares	0.12	Short-term investment vehicle	Long	USA
IOVA Iovance Biotherapeutics, Inc.	253.37 k	27.19 k shares	0.11	Common equity	Long	USA
IDYA IDEAYA Biosciences, Inc.	247.85 k	9.06 k shares	0.11	Common equity	Long	USA
IMCR Immunocore Holdings plc	237.55 k	276.00 k principal	0.10	Debt	Long	UK
IMTX Immatics N.V.	224.30 k	26.96 k shares	0.10	Common equity	Long	Germany
ARVN Arvinas, Inc.	219.05 k	8.20 k shares	0.10	Common equity	Long	USA
ORIC ORIC Pharmaceuticals, Inc.	203.78 k	20.58 k shares	0.09	Common equity	Long	USA
ALLO Allogene Therapeutics, Inc.	202.33 k	81.58 k shares	0.09	Common equity	Long	USA
GERN Geron Corporation	197.82 k	48.01 k shares	0.09	Common equity	Long	USA
APLS Apellis Pharmaceuticals, Inc.	193.37 k	5.70 k shares	0.09	Common equity	Long	USA
PRTA Prothena Corporation plc	190.53 k	11.75 k shares	0.08	Common equity	Long	Ireland
SYRE Spyre Therapeutics, Inc.	190.51 k	6.70 k shares	0.08	Common equity	Long	USA
BCAX Bicara Therapeutics Inc. Common Stock	185.78 k	8.94 k shares	0.08	Common equity	Long	USA
PLRX Pliant Therapeutics, Inc.	184.88 k	13.40 k shares	0.08	Common equity	Long	USA
MBX MBX Biosciences, Inc. Common Stock	183.85 k	9.04 k shares	0.08	Common equity	Long	USA
ORKA Oruka Therapeutics Inc.	180.25 k	8.30 k shares	0.08	Common equity	Long	USA
IGMS IGM Biosciences, Inc.	178.20 k	17.75 k shares	0.08	Common equity	Long	USA
PHVS Pharvaris N.V.	177.30 k	8.10 k shares	0.08	Common equity	Long	Netherlands
HLXB Helix Acquisition Corp. II	168.86 k	16.22 k shares	0.07	Common equity	Long	Cayman Islands
SEPN Septerna, Inc. Common Stock	163.96 k	6.48 k shares	0.07	Common equity	Long	USA
TRDA Entrada Therapeutics, Inc.	160.81 k	8.09 k shares	0.07	Common equity	Long	USA
OCUL Ocular Therapeutix, Inc.	151.32 k	15.30 k shares	0.07	Common equity	Long	USA
VYGR Voyager Therapeutics, Inc.	147.68 k	21.53 k shares	0.07	Common equity	Long	USA
MRNA Moderna, Inc.	137.79 k	3.20 k shares	0.06	Common equity	Long	USA
ANAB AnaptysBio, Inc.	134.78 k	5.40 k shares	0.06	Common equity	Long	USA
SENSORION SA COMMON STOCK EUR.1	133.04 k	181.94 k shares	0.06	Common equity	Long	France
EYPT EyePoint Pharmaceuticals, Inc.	132.25 k	14.94 k shares	0.06	Common equity	Long	USA
LYEL Lyell Immunopharma, Inc.	131.28 k	138.90 k shares	0.06	Common equity	Long	USA
SANA Sana Biotechnology, Inc.	129.26 k	46.50 k shares	0.06	Common equity	Long	USA
RLAY Relay Therapeutics, Inc.	126.39 k	26.89 k shares	0.06	Common equity	Long	USA
ANNX Annexon, Inc.	123.51 k	22.92 k shares	0.05	Common equity	Long	USA
NMRA Neumora Therapeutics, Inc. Common Stock	119.24 k	12.00 k shares	0.05	Common equity	Long	USA
EHC Encompass Health Corporation	113.23 k	1.10 k shares	0.05	Common equity	Long	USA
AURA Aura Biosciences, Inc.	109.51 k	11.76 k shares	0.05	Common equity	Long	USA
SPRY ARS Pharmaceuticals, Inc.	105.92 k	7.30 k shares	0.05	Common equity	Long	USA
BIOA BioAge Labs, Inc.	98.19 k	5.22 k shares	0.04	Common equity	Long	USA
KOD Kodiak Sciences Inc.	98.05 k	14.70 k shares	0.04	Common equity	Long	USA
ZNTL Zentalis Pharmaceuticals, Inc.	97.31 k	26.96 k shares	0.04	Common equity	Long	USA
MGNX MacroGenics, Inc.	90.70 k	25.26 k shares	0.04	Common equity	Long	USA
CRBP Corbus Pharmaceuticals Holdings, Inc.	78.41 k	4.40 k shares	0.03	Common equity	Long	USA
AUTL Autolus Therapeutics plc	77.93 k	23.47 k shares	0.03	Common equity	Long	UK
WGS GeneDx Holdings Corp.	77.61 k	990.00 shares	0.03	Common equity	Long	USA
VRDN Viridian Therapeutics, Inc.	77.58 k	3.60 k shares	0.03	Common equity	Long	USA
IMRX Immuneering Corporation	70.88 k	33.91 k shares	0.03	Common equity	Long	USA
NxStage Medical, Inc.	70.44 k	36.88 k shares	0.03	Common equity	Long	USA
OBIO Orchestra BioMed Holdings, Inc.	70.39 k	12.50 k shares	0.03	Common equity	Long	USA
SGMT Sagimet Biosciences Inc.	69.42 k	12.20 k shares	0.03	Common equity	Long	USA
GBIO Generation Bio Co.	69.30 k	45.59 k shares	0.03	Common equity	Long	USA
GOSS Gossamer Bio, Inc.	69.09 k	98.96 k shares	0.03	Common equity	Long	USA
URGN UroGen Pharma Ltd.	59.69 k	4.70 k shares	0.03	Common equity	Long	USA
TERN Terns Pharmaceuticals, Inc.	54.09 k	8.67 k shares	0.02	Common equity	Long	USA
KYTX Kyverna Therapeutics, Inc.	51.86 k	8.99 k shares	0.02	Common equity	Long	USA
NGNE Neurogene Inc.	50.86 k	2.00 k shares	0.02	Common equity	Long	USA
SAGE Sage Therapeutics, Inc.	49.85 k	9.11 k shares	0.02	Common equity	Long	USA
KRRO Korro Bio, Inc.	46.85 k	900.00 shares	0.02	Common equity	Long	USA
ANRO Alto Neuroscience, Inc.	43.06 k	9.76 k shares	0.02	Common equity	Long	USA
CABA Cabaletta Bio, Inc.	39.72 k	10.40 k shares	0.02	Common equity	Long	USA
ALEC Alector, Inc.	39.31 k	15.18 k shares	0.02	Common equity	Long	USA
DAWN Day One Biopharmaceuticals, Inc.	34.38 k	2.47 k shares	0.02	Common equity	Long	USA
THRD Third Harmonic Bio, Inc.	33.14 k	2.60 k shares	0.01	Common equity	Long	USA
CCCC C4 Therapeutics, Inc.	25.94 k	5.70 k shares	0.01	Common equity	Long	USA
CLYM Climb Bio, Inc.	25.52 k	7.90 k shares	0.01	Common equity	Long	USA
APLT Applied Therapeutics, Inc.	22.94 k	11.30 k shares	0.01	Common equity	Long	USA
DNA Ginkgo Bioworks Holdings, Inc.	19.81 k	2.28 k shares	0.01	Common equity	Long	USA
PRLD Prelude Therapeutics Incorporated	18.05 k	17.19 k shares	0.01	Common equity	Long	USA
BNTC Benitec Biopharma Inc.	9.68 k	959.00 shares	0.00	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	2.30 k	6.52 k shares	0.00	Common equity	Long	USA
WGS GeneDx Holdings Corp.	1.21 k	7.15 k shares	0.00	Common equity	Long	USA
SLGCW SomaLogic, Inc.	292.90	2.90 k shares	0.00	Common equity	Long	USA