Health Sciences Fund

Fund Profile

Fund profile

Fund manager

John Hancock Funds II

Total assets

$324.74 mm

Liabilities

$416.13 k

Net assets

$324.33 mm

Number of holdings

209.00

Top 200 of 209 Holdings

As of Nov 2022

Security	$Holding	Balance	% of Fund	Category	Position	Country
UNH Unitedhealth Group Inc	27.43 mm	50.08 k shares	8.46	Common equity	Long	USA
TMO Thermo Fisher Scientific Inc.	16.32 mm	29.13 k shares	5.03	Common equity	Long	USA
LLY Lilly(Eli) & Co	14.55 mm	39.21 k shares	4.49	Common equity	Long	USA
DHR Danaher Corp.	12.45 mm	45.52 k shares	3.84	Common equity	Long	USA
ISRG Intuitive Surgical Inc	10.95 mm	40.50 k shares	3.38	Common equity	Long	USA
ASTRAZENECA PLC ADR	10.48 mm	154.17 k shares	3.23	Common equity	Long	UK
ELV Elevance Health Inc	10.21 mm	19.16 k shares	3.15	Common equity	Long	USA
MRK Merck & Co Inc	9.28 mm	84.28 k shares	2.86	Common equity	Long	USA
REGN Regeneron Pharmaceuticals, Inc.	9.03 mm	12.01 k shares	2.78	Common equity	Long	USA
PFE Pfizer Inc.	7.83 mm	156.15 k shares	2.41	Common equity	Long	USA
VRTX Vertex Pharmaceuticals, Inc.	7.80 mm	24.65 k shares	2.40	Common equity	Long	USA
HUM Humana Inc.	7.65 mm	13.91 k shares	2.36	Common equity	Long	USA
SYK Stryker Corp.	6.95 mm	29.71 k shares	2.14	Common equity	Long	USA
ALNY Alnylam Pharmaceuticals Inc	6.43 mm	29.13 k shares	1.98	Common equity	Long	USA
A Agilent Technologies Inc.	6.40 mm	41.29 k shares	1.97	Common equity	Long	USA
CNC Centene Corp.	6.32 mm	72.61 k shares	1.95	Common equity	Long	USA
ARGX Argen X SE	5.77 mm	14.51 k shares	1.78	Common equity	Long	Netherlands
ABBV Abbvie Inc	5.38 mm	33.38 k shares	1.66	Common equity	Long	USA
BDX Becton, Dickinson And Co.	4.98 mm	19.96 k shares	1.53	Common equity	Long	USA
MOH Molina Healthcare Inc	4.84 mm	14.37 k shares	1.49	Common equity	Long	USA
Cigna Holding Co	4.62 mm	14.03 k shares	1.42	Common equity	Long	USA
MRNA Moderna Inc	4.40 mm	25.02 k shares	1.36	Common equity	Long	USA
ABMD Abiomed Inc	3.39 mm	13.35 k shares	1.04	Common equity	Long	USA
DAIICHI SANKYO CO LTD COMMON STOCK	3.20 mm	96.50 k shares	0.99	Common equity	Long	Japan
CLH Clean Harbors, Inc.	3.17 mm	41.67 k shares	0.98	Common equity	Long	USA
GENMAB A/S COMMON STOCK DKK1.0	3.05 mm	6.59 k shares	0.94	Common equity	Long	Denmark
VEEV Veeva Systems Inc	2.88 mm	15.12 k shares	0.89	Common equity	Long	USA
HCA HCA Healthcare Inc	2.81 mm	11.71 k shares	0.87	Common equity	Long	USA
KRTX Karuna Therapeutics Inc	2.75 mm	11.69 k shares	0.85	Common equity	Long	USA
DXCM Dexcom Inc	2.68 mm	23.01 k shares	0.82	Common equity	Long	USA
PEN Penumbra Inc	2.65 mm	12.65 k shares	0.82	Common equity	Long	USA
BRKR Bruker Corp	2.62 mm	38.94 k shares	0.81	Common equity	Long	USA
ROCHE HOLDING AG COMMON STOCK	2.52 mm	7.71 k shares	0.78	Common equity	Long	Switzerland
PODD Insulet Corporation	2.46 mm	8.21 k shares	0.76	Common equity	Long	USA
BIIB Biogen Inc	2.38 mm	7.80 k shares	0.73	Common equity	Long	USA
ADAP Adaptimmune Therapeutics Plc	2.16 mm	17.57 k shares	0.67	Common equity	Long	Denmark
BNTX BioNTech SE	2.12 mm	12.67 k shares	0.65	Common equity	Long	Germany
AVTR Avantor Inc.	1.94 mm	87.00 k shares	0.60	Common equity	Long	USA
SARTORIUS AG PREFERENCE	1.91 mm	5.08 k shares	0.59	Preferred equity	Long	Germany
NVCR NovoCure Ltd	1.86 mm	24.26 k shares	0.57	Common equity	Long	Jersey
WST West Pharmaceutical Services, Inc.	1.85 mm	7.88 k shares	0.57	Common equity	Long	USA
JNJ Johnson & Johnson	1.84 mm	10.32 k shares	0.57	Common equity	Long	USA
TFX Teleflex Incorporated	1.58 mm	6.74 k shares	0.49	Common equity	Long	USA
MTD Mettler-Toledo International, Inc.	1.47 mm	997.00 shares	0.45	Common equity	Long	USA
CRL Charles River Laboratories International Inc.	1.42 mm	6.22 k shares	0.44	Common equity	Long	USA
INCY Incyte Corp.	1.41 mm	17.72 k shares	0.44	Common equity	Long	USA
Royalty Pharma Plc	1.40 mm	31.89 k shares	0.43	Common equity	Long	USA
TXG 10x Genomics Inc	1.27 mm	32.96 k shares	0.39	Common equity	Long	USA
IMCR Immunocore Holdings plc	1.24 mm	19.70 k shares	0.38	Common equity	Long	UK
ZTS Zoetis Inc	1.23 mm	7.95 k shares	0.38	Common equity	Long	USA
ILMN Illumina Inc	1.21 mm	5.55 k shares	0.37	Common equity	Long	USA
IONS Ionis Pharmaceuticals Inc	1.21 mm	29.61 k shares	0.37	Common equity	Long	USA
SSC GOVERNMENT MM GVMXX	1.18 mm	1.18 mm shares	0.36	Short-term investment vehicle	Long	USA
SRPT Sarepta Therapeutics Inc	1.16 mm	9.42 k shares	0.36	Common equity	Long	USA
MRTX Mirati Therapeutics Inc	1.13 mm	12.39 k shares	0.35	Common equity	Long	USA
EXAS Exact Sciences Corp.	1.12 mm	25.01 k shares	0.35	Common equity	Long	USA
DOCS Doximity Inc	1.08 mm	31.85 k shares	0.33	Common equity	Long	USA
NBIX Neurocrine Biosciences, Inc.	1.03 mm	8.13 k shares	0.32	Common equity	Long	USA
OLK Olink Holding AB (publ)	1.03 mm	43.11 k shares	0.32	Common equity	Long	Sweden
GH Guardant Health Inc	1.02 mm	19.40 k shares	0.31	Common equity	Long	USA
CERE Cerevel Therapeutics Holdings Inc	1.01 mm	35.00 k shares	0.31	Common equity	Long	USA
CTLT Catalent Inc.	1.00 mm	20.02 k shares	0.31	Common equity	Long	USA
BPMC Blueprint Medicines Corp	1.00 mm	20.93 k shares	0.31	Common equity	Long	USA
ZBH Zimmer Biomet Holdings Inc	996.11 k	8.29 k shares	0.31	Common equity	Long	USA
STERIS Plc (Ireland)	995.38 k	5.36 k shares	0.31	Common equity	Long	USA
GE General Electric Co.	975.59 k	11.35 k shares	0.30	Common equity	Long	USA
INSM Insmed Inc	944.89 k	51.10 k shares	0.29	Common equity	Long	USA
SGEN Seagen Inc	925.11 k	7.62 k shares	0.29	Common equity	Long	USA
WRBY Warby Parker Inc	902.27 k	52.98 k shares	0.28	Common equity	Long	USA
COO Cooper Companies, Inc.	898.43 k	2.84 k shares	0.28	Common equity	Long	USA
EISAI CO LTD COMMON STOCK	888.13 k	13.00 k shares	0.27	Common equity	Long	Japan
BMRN Biomarin Pharmaceutical Inc. - Registered Shares	879.54 k	8.71 k shares	0.27	Common equity	Long	USA
TECH Bio-Techne Corp	864.86 k	10.18 k shares	0.27	Common equity	Long	USA
WAT Waters Corp.	858.18 k	2.48 k shares	0.26	Common equity	Long	USA
RARE Ultragenyx Pharmaceutical Inc.	855.37 k	23.56 k shares	0.26	Common equity	Long	USA
ROWE T PRICE GOV RES FD 20340919 00000.0000000000	843.72 k	843.72 k shares	0.26	Short-term investment vehicle	Long	USA
EXEL Exelixis Inc	821.65 k	48.11 k shares	0.25	Common equity	Long	USA
ISEE IVERIC bio Inc	806.36 k	34.14 k shares	0.25	Common equity	Long	USA
DNLI Denali Therapeutics Inc	795.07 k	24.92 k shares	0.25	Common equity	Long	USA
PRTA Prothena Corporation plc	786.88 k	12.59 k shares	0.24	Common equity	Long	Ireland
RGEN Repligen Corp.	786.00 k	4.40 k shares	0.24	Common equity	Long	USA
APLS Apellis Pharmaceuticals Inc	780.66 k	15.64 k shares	0.24	Common equity	Long	USA
QDEL QuidelOrtho Corp	715.60 k	8.17 k shares	0.22	Common equity	Long	USA
IRTC iRhythm Technologies Inc	696.61 k	6.39 k shares	0.21	Common equity	Long	USA
ALCON INC COMMON STOCK CHF.04	624.98 k	9.06 k shares	0.19	Common equity	Long	Switzerland
CFRX ContraFect Corp	605.69 k	56.34 k shares	0.19	Common equity	Long	USA
Medtronic Plc	600.70 k	7.60 k shares	0.19	Common equity	Long	Ireland
NARI Inari Medical Inc	598.35 k	8.13 k shares	0.18	Common equity	Long	USA
LEGN Legend Biotech Corp	567.43 k	11.02 k shares	0.17	Common equity	Long	USA
BGNE BeiGene Ltd	563.53 k	2.94 k shares	0.17	Common equity	Long	China
DICE DICE Therapeutics Inc	558.67 k	16.05 k shares	0.17	Common equity	Long	USA
XNCR Xencor Inc	552.02 k	18.57 k shares	0.17	Common equity	Long	USA
PRCT Procept BioRobotics Corp	550.84 k	12.84 k shares	0.17	Common equity	Long	USA
TEF Telefonica S.A	546.51 k	11.75 k shares	0.17	Common equity	Long	USA
RVMD Revolution Medicines Inc	530.14 k	22.47 k shares	0.16	Common equity	Long	USA
CLDX Celldex Therapeutics Inc.	520.85 k	14.04 k shares	0.16	Common equity	Long	USA
SAGE Sage Therapeutics Inc	506.19 k	12.33 k shares	0.16	Common equity	Long	USA
ARVN Arvinas Inc	482.79 k	11.76 k shares	0.15	Common equity	Long	USA
REPL Replimune Group Inc	480.33 k	23.47 k shares	0.15	Common equity	Long	USA
KYMR Kymera Therapeutics Inc	478.08 k	16.50 k shares	0.15	Common equity	Long	USA
RLAY Relay Therapeutics Inc	475.48 k	25.59 k shares	0.15	Common equity	Long	USA
FATE Fate Therapeutics Inc	467.53 k	22.46 k shares	0.14	Common equity	Long	USA
ALLO Allogene Therapeutics Inc	460.84 k	46.74 k shares	0.14	Common equity	Long	USA
IQV IQVIA Holdings Inc	460.02 k	2.11 k shares	0.14	Common equity	Long	USA
ACERTA FUTURE PAYMENTS PP TC30M7746	453.92 k	504.36 k shares	0.14	Common equity	Long	USA
WUXI BIOLOGICS CAYMAN INC COMMON STOCK USD.00001	445.65 k	68.00 k shares	0.14	Common equity	Long	China
OPCH Option Care Health Inc. - Registered Shares	445.00 k	14.78 k shares	0.14	Common equity	Long	USA
ACAD Acadia Pharmaceuticals Inc	428.37 k	27.50 k shares	0.13	Common equity	Long	USA
ALHC Alignment Healthcare Inc	424.32 k	31.90 k shares	0.13	Common equity	Long	USA
NTLA Intellia Therapeutics Inc	423.26 k	8.23 k shares	0.13	Common equity	Long	USA
VTRS Viatris Inc	420.47 k	38.12 k shares	0.13	Common equity	Long	USA
BAYER AG COMMON STOCK	414.33 k	7.14 k shares	0.13	Common equity	Long	Germany
ZLAB Zai Lab Limited	395.47 k	10.26 k shares	0.12	Common equity	Long	China
CRSP CRISPR Therapeutics AG	389.39 k	7.11 k shares	0.12	Common equity	Long	Switzerland
CYTK Cytokinetics Inc	376.68 k	8.86 k shares	0.12	Common equity	Long	USA
RCUS Arcus Biosciences Inc	371.92 k	10.58 k shares	0.11	Common equity	Long	USA
LONZA GROUP AG COMMON STOCK CHF1.0	366.69 k	697.00 shares	0.11	Common equity	Long	Switzerland
LNTH Lantheus Holdings Inc	366.64 k	5.91 k shares	0.11	Common equity	Long	USA
ZNTL Zentalis Pharmaceuticals Inc	347.13 k	15.69 k shares	0.11	Common equity	Long	USA
SRRK Scholar Rock Holding Corp	340.06 k	43.77 k shares	0.10	Common equity	Long	USA
RAPT RAPT Therapeutics Inc	324.00 k	18.33 k shares	0.10	Common equity	Long	USA
BHVN Biohaven Ltd.	320.15 k	20.24 k shares	0.10	Common equity	Long	USA
OVID Ovid Therapeutics Inc	303.80 k	14.31 k shares	0.09	Common equity	Long	USA
GLUE Monte Rosa Therapeutics Inc	297.34 k	35.06 k shares	0.09	Common equity	Long	USA
CERT Certara Inc	294.91 k	17.37 k shares	0.09	Common equity	Long	USA
PTCT PTC Therapeutics Inc	293.87 k	7.08 k shares	0.09	Common equity	Long	USA
VTYX Ventyx Biosciences Inc	291.38 k	10.05 k shares	0.09	Common equity	Long	USA
RNA Avidity Biosciences Inc	288.97 k	24.83 k shares	0.09	Common equity	Long	USA
OSH Oak Street Health Inc	288.35 k	13.34 k shares	0.09	Common equity	Long	USA
SGRY Surgery Partners Inc	287.04 k	10.14 k shares	0.09	Common equity	Long	USA
M3 INC COMMON STOCK	282.26 k	9.00 k shares	0.09	Common equity	Long	Japan
AGIO Agios Pharmaceuticals Inc	281.66 k	9.35 k shares	0.09	Common equity	Long	USA
RCKT Rocket Pharmaceuticals Inc	264.74 k	14.02 k shares	0.08	Common equity	Long	USA
SHIMADZU CORP COMMON STOCK	252.02 k	8.20 k shares	0.08	Common equity	Long	Japan
ELAN Elanco Animal Health Inc	251.74 k	19.56 k shares	0.08	Common equity	Long	USA
IOVA Iovance Biotherapeutics Inc	251.55 k	39.31 k shares	0.08	Common equity	Long	USA
ACHC Acadia Healthcare Company Inc	249.37 k	2.80 k shares	0.08	Common equity	Long	USA
PRME Prime Medicine Inc	248.24 k	14.44 k shares	0.08	Common equity	Long	USA
NVRO Nevro Corp	246.30 k	5.27 k shares	0.08	Common equity	Long	USA
IGMS IGM Biosciences Inc	243.58 k	11.07 k shares	0.08	Common equity	Long	USA
IMRX Immuneering Corp	243.47 k	37.51 k shares	0.08	Common equity	Long	USA
GBIO Generation Bio Co	243.01 k	45.59 k shares	0.07	Common equity	Long	USA
REVH Revolution Healthcare Acquisition Corp	242.20 k	24.12 k shares	0.07	Common equity	Long	USA
EVOTEC SE COMMON STOCK	240.30 k	13.45 k shares	0.07	Common equity	Long	Germany
TRDA Entrada Therapeutics Inc	227.05 k	15.17 k shares	0.07	Common equity	Long	USA
TWST Twist Bioscience Corp	227.03 k	8.30 k shares	0.07	Common equity	Long	USA
AGL Agilon Health Inc	223.06 k	12.70 k shares	0.07	Common equity	Long	USA
KROS Keros Therapeutics Inc	207.18 k	4.16 k shares	0.06	Common equity	Long	USA
ADPT Adaptive Biotechnologies Corp	206.10 k	23.47 k shares	0.06	Common equity	Long	USA
SEER Seer Inc	206.04 k	31.90 k shares	0.06	Common equity	Long	USA
IMTX Immatics N.V	193.79 k	18.39 k shares	0.06	Common equity	Long	Germany
LYEL Lyell Immunopharma Inc	190.32 k	45.21 k shares	0.06	Common equity	Long	USA
OBIO Orchestra BioMed Holdings Inc	189.74 k	19.17 k shares	0.06	Common equity	Long	USA
NUVL Nuvalent Inc	187.15 k	5.69 k shares	0.06	Common equity	Long	USA
MORF Morphic Holding Inc	185.95 k	6.76 k shares	0.06	Common equity	Long	USA
FGEN FibroGen Inc	185.73 k	12.93 k shares	0.06	Common equity	Long	USA
DNA Ginkgo Bioworks Holdings Inc	181.29 k	91.10 k shares	0.06	Common equity	Long	USA
DCPH Deciphera Pharmaceuticals Inc	175.01 k	11.00 k shares	0.05	Common equity	Long	USA
ALLK Allakos Inc	174.32 k	21.13 k shares	0.05	Common equity	Long	USA
NRIX Nurix Therapeutics Inc	172.25 k	13.90 k shares	0.05	Common equity	Long	USA
MLTX MoonLake Immunotherapeutics	170.80 k	17.74 k shares	0.05	Common equity	Long	Switzerland
THRX Theseus Pharmaceuticals Inc	166.21 k	25.22 k shares	0.05	Common equity	Long	USA
SANA Sana Biotechnology Inc	164.75 k	33.02 k shares	0.05	Common equity	Long	USA
ALGN Align Technology, Inc.	157.52 k	801.00 shares	0.05	Common equity	Long	USA
CINC CinCor Pharma Inc	157.28 k	13.33 k shares	0.05	Common equity	Long	USA
ENTA Enanta Pharmaceuticals Inc	150.42 k	3.44 k shares	0.05	Common equity	Long	USA
RXDX Prometheus Biosciences Inc	146.76 k	3.57 k shares	0.05	Common equity	Long	USA
GOSS Gossamer Bio Inc	144.21 k	16.85 k shares	0.04	Common equity	Long	USA
THRD Third Harmonic Bio Inc	143.70 k	7.37 k shares	0.04	Common equity	Long	USA
BCYC Bicycle Therapeutics Plc	139.96 k	4.83 k shares	0.04	Common equity	Long	UK
CNTA Centessa Pharmaceuticals plc	137.48 k	34.37 k shares	0.04	Common equity	Long	USA
CCCC C4 Therapeutics Inc	135.00 k	15.75 k shares	0.04	Common equity	Long	USA
RGNX Regenxbio Inc	132.57 k	5.55 k shares	0.04	Common equity	Long	USA
KOD Kodiak Sciences Inc	130.96 k	17.75 k shares	0.04	Common equity	Long	USA
ALEC Alector Inc	128.86 k	15.18 k shares	0.04	Common equity	Long	USA
PLRX Pliant Therapeutics Inc	125.61 k	6.83 k shares	0.04	Common equity	Long	USA
VYGR Voyager Therapeutics Inc	110.44 k	18.59 k shares	0.03	Common equity	Long	USA
ADCT Adc Therapeutics SA	109.92 k	30.03 k shares	0.03	Common equity	Long	Switzerland
QTRX Quanterix Corp	108.38 k	8.15 k shares	0.03	Common equity	Long	USA
ARDX Ardelyx Inc	102.52 k	59.60 k shares	0.03	Common equity	Long	USA
MRVI Maravai LifeSciences Holdings Inc	96.27 k	6.47 k shares	0.03	Common equity	Long	USA
SWTX SpringWorks Therapeutics Inc	90.51 k	3.74 k shares	0.03	Common equity	Long	USA
TNYA Tenaya Therapeutics Inc	89.65 k	33.83 k shares	0.03	Common equity	Long	USA
EQRX EQRx Inc	88.39 k	23.51 k shares	0.03	Common equity	Long	USA
STOK Stoke Therapeutics Inc	84.30 k	11.18 k shares	0.03	Common equity	Long	USA
GLPG Galapagos NV	79.54 k	2.00 k shares	0.02	Common equity	Long	Belgium
DSGN Design Therapeutics Inc	75.95 k	5.43 k shares	0.02	Common equity	Long	USA
LIAN LianBio	75.05 k	47.80 k shares	0.02	Common equity	Long	Cayman Islands
MGTX MeiraGTx Holdings plc	74.93 k	12.16 k shares	0.02	Common equity	Long	USA
SOPH SOPHiA Genetics SA	73.38 k	31.77 k shares	0.02	Common equity	Long	Switzerland
IDYA Ideaya Biosciences Inc	65.94 k	3.69 k shares	0.02	Common equity	Long	USA
SNTI Senti Biosciences Inc.	61.58 k	26.77 k shares	0.02	Common equity	Long	USA
AADI Aadi Bioscience Inc	59.02 k	4.41 k shares	0.02	Common equity	Long	USA
IVVD Invivyd Inc	53.90 k	23.85 k shares	0.02	Common equity	Long	USA
EXAI Exscientia Plc	51.21 k	8.98 k shares	0.02	Common equity	Long	UK
LBPH Longboard Pharmaceuticals Inc	50.64 k	9.43 k shares	0.02	Common equity	Long	USA
RPID Rapid Micro Biosystems Inc	38.27 k	18.67 k shares	0.01	Common equity	Long	USA
PROGENIC PHARMACEUTICALS INC. COMMON STOCK	38.21 k	33.20 k shares	0.01	Common equity	Long	USA
PRLD Prelude Therapeutics Inc	36.99 k	5.55 k shares	0.01	Common equity	Long	USA
BNR Burning Rock Biotech Ltd	29.52 k	11.76 k shares	0.01	Common equity	Long	China