Select Biotechnology Portfolio

Fund Profile

Fund profile

Tickers

FBIOX

Fund manager

Fidelity Select Technology Portfolio

Total assets

$5.06 bn

Liabilities

$310.13 mm

Net assets

$4.75 bn

Number of holdings

190.00

190 Holdings

As of Nov 2024

Security	$Holding	Balance	% of Fund	Category	Position	Country
ABBV AbbVie Inc.	544.16 mm	2.97 mm shares	11.45	Common equity	Long	USA
AMGN Amgen Inc.	419.71 mm	1.48 mm shares	8.83	Common equity	Long	USA
KRYS Krystal Biotech, Inc.	370.70 mm	1.88 mm shares	7.80	Common equity	Long	USA
Fidelity Securities Lending Cash Central Fund	295.79 mm	295.76 mm shares	6.23	Short-term investment vehicle	Long	USA
VRTX Vertex Pharmaceuticals Incorporated	221.52 mm	473.21 k shares	4.66	Common equity	Long	USA
ALNY Alnylam Pharmaceuticals, Inc.	164.97 mm	651.87 k shares	3.47	Common equity	Long	USA
REGN Regeneron Pharmaceuticals, Inc.	154.68 mm	206.18 k shares	3.26	Common equity	Long	USA
GILD Gilead Sciences, Inc.	153.37 mm	1.66 mm shares	3.23	Common equity	Long	USA
ARGENX SE SPONSORED ADR	106.05 mm	172.00 k shares	2.23	Common equity	Long	Netherlands
UCB SA	104.39 mm	532.97 k shares	2.20	Common equity	Long	Belgium
ACLX Arcellx, Inc.	91.94 mm	1.04 mm shares	1.94	Common equity	Long	USA
ASND Ascendis Pharma A/S	89.73 mm	659.41 k shares	1.89	Common equity	Long	Denmark
PCVX Vaxcyte, Inc.	84.47 mm	895.38 k shares	1.78	Common equity	Long	USA
ZEALAND PHARMA A/S	77.81 mm	752.23 k shares	1.64	Common equity	Long	Denmark
BIOHAVEN LTD	76.60 mm	1.66 mm shares	1.61	Common equity	Long	Virgin Islands (British)
INSM Insmed Incorporated	75.15 mm	999.82 k shares	1.58	Common equity	Long	USA
SRRK Scholar Rock Holding Corporation	65.14 mm	1.63 mm shares	1.37	Common equity	Long	USA
ARRIVENT BIOPHARMA INC	58.95 mm	1.97 mm shares	1.24	Common equity	Long	USA
NTRA Natera, Inc.	58.64 mm	349.53 k shares	1.23	Common equity	Long	USA
UTHR United Therapeutics Corporation	58.50 mm	157.89 k shares	1.23	Common equity	Long	USA
SMMT Summit Therapeutics Inc.	56.13 mm	3.04 mm shares	1.18	Common equity	Long	USA
CRNX Crinetics Pharmaceuticals, Inc.	55.18 mm	964.65 k shares	1.16	Common equity	Long	USA
CNTA Centessa Pharmaceuticals plc	53.31 mm	2.98 mm shares	1.12	Common equity	Long	UK
IRON Disc Medicine, Inc.	49.19 mm	775.29 k shares	1.04	Common equity	Long	USA
BPMC Blueprint Medicines Corporation	47.55 mm	493.35 k shares	1.00	Common equity	Long	USA
MERUS B.V.	44.66 mm	996.05 k shares	0.94	Common equity	Long	Netherlands
MDGL Madrigal Pharmaceuticals, Inc.	44.40 mm	135.29 k shares	0.93	Common equity	Long	USA
KROS Keros Therapeutics, Inc.	43.14 mm	747.18 k shares	0.91	Common equity	Long	USA
BIO AB2 HOLDINGS LLC ARC	37.14 mm	1.95 mm shares	0.78	Common equity	Long	USA
RNA Avidity Biosciences, Inc.	34.67 mm	805.72 k shares	0.73	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	33.85 mm	585.10 k shares	0.71	Common equity	Long	USA
MRNA Moderna, Inc.	33.10 mm	768.62 k shares	0.70	Common equity	Long	USA
TGTX TG Therapeutics, Inc.	32.98 mm	947.72 k shares	0.69	Common equity	Long	USA
MNKD MannKind Corporation	29.88 mm	4.41 mm shares	0.63	Common equity	Long	USA
RCUS Arcus Biosciences, Inc.	29.01 mm	1.88 mm shares	0.61	Common equity	Long	USA
ROIVANT SCIENCES LTD	28.27 mm	2.22 mm shares	0.59	Common equity	Long	Bermuda
VERA Vera Therapeutics, Inc.	28.22 mm	567.33 k shares	0.59	Common equity	Long	USA
MLTX MoonLake Immunotherapeutics	27.81 mm	510.86 k shares	0.59	Common equity	Long	Cayman Islands
RARE Ultragenyx Pharmaceutical Inc.	27.52 mm	577.73 k shares	0.58	Common equity	Long	USA
NUVL Nuvalent, Inc.	26.00 mm	268.90 k shares	0.55	Common equity	Long	USA
NRIX Nurix Therapeutics, Inc.	25.25 mm	1.14 mm shares	0.53	Common equity	Long	USA
DYN Dyne Therapeutics, Inc.	24.13 mm	788.47 k shares	0.51	Common equity	Long	USA
CORT Corcept Therapeutics Incorporated	24.13 mm	418.35 k shares	0.51	Common equity	Long	USA
VKTX Viking Therapeutics, Inc.	23.59 mm	445.56 k shares	0.50	Common equity	Long	USA
XENE Xenon Pharmaceuticals Inc.	23.00 mm	539.63 k shares	0.48	Common equity	Long	Canada
VRDN Viridian Therapeutics, Inc.	22.71 mm	1.05 mm shares	0.48	Common equity	Long	USA
BNTX BioNTech SE	20.78 mm	175.50 k shares	0.44	Common equity	Long	Germany
NATIONAL RESILIENCE INC SER B PC PP	20.24 mm	732.06 k shares	0.43	Preferred equity	Long	USA
BRIDGEBIO PHARMA INC PIPE	19.87 mm	733.41 k shares	0.42	Common equity	Long	USA
IDYA IDEAYA Biosciences, Inc.	19.63 mm	717.56 k shares	0.41	Common equity	Long	USA
IMVT Immunovant, Inc.	18.77 mm	665.62 k shares	0.40	Common equity	Long	USA
PTGX Protagonist Therapeutics, Inc.	18.57 mm	423.91 k shares	0.39	Common equity	Long	USA
PRAX Praxis Precision Medicines, Inc.	18.56 mm	231.51 k shares	0.39	Common equity	Long	USA
TSHA Taysha Gene Therapies, Inc.	18.05 mm	5.57 mm shares	0.38	Common equity	Long	USA
APGE Apogee Therapeutics, Inc.	17.70 mm	392.13 k shares	0.37	Common equity	Long	USA
GERN Geron Corporation	17.63 mm	4.28 mm shares	0.37	Common equity	Long	USA
DNLI Denali Therapeutics Inc.	16.91 mm	676.56 k shares	0.36	Common equity	Long	USA
JANX Janux Therapeutics, Inc.	16.56 mm	366.40 k shares	0.35	Common equity	Long	USA
IONS Ionis Pharmaceuticals, Inc.	15.81 mm	442.38 k shares	0.33	Common equity	Long	USA
SPRY ARS Pharmaceuticals, Inc.	15.71 mm	1.08 mm shares	0.33	Common equity	Long	USA
VRNA Verona Pharma plc	15.65 mm	394.99 k shares	0.33	Common equity	Long	UK
PTCT PTC Therapeutics, Inc.	15.49 mm	352.91 k shares	0.33	Common equity	Long	USA
RNAC Cartesian Therapeutics, Inc.	15.35 mm	815.35 k shares	0.32	Common equity	Long	USA
ORUKA THERAPEUTICS INC PIPE	15.32 mm	704.88 k shares	0.32	Common equity	Long	USA
SENSORION SA	14.83 mm	20.28 mm shares	0.31	Common equity	Long	France
NTLA Intellia Therapeutics, Inc.	13.74 mm	879.92 k shares	0.29	Common equity	Long	USA
DAWN Day One Biopharmaceuticals, Inc.	13.73 mm	985.73 k shares	0.29	Common equity	Long	USA
NUVB Nuvation Bio Inc.	13.64 mm	4.70 mm shares	0.29	Common equity	Long	USA
CYTK Cytokinetics, Incorporated	13.58 mm	261.85 k shares	0.29	Common equity	Long	USA
PROTHENA CORP PLC	11.96 mm	738.12 k shares	0.25	Common equity	Long	Ireland
ELVN Enliven Therapeutics, Inc.	11.68 mm	479.04 k shares	0.25	Common equity	Long	USA
TECTONIC THERAPEUTIC INC PIPE	10.73 mm	215.51 k shares	0.23	Common equity	Long	USA
PHAT Phathom Pharmaceuticals, Inc.	10.72 mm	1.21 mm shares	0.23	Common equity	Long	USA
COGT Cogent Biosciences, Inc.	10.71 mm	1.13 mm shares	0.23	Common equity	Long	USA
CRISPR THERAPEUTICS AG	10.34 mm	202.01 k shares	0.22	Common equity	Long	Switzerland
BIO AB2 HOLDINGS LLC ADI	10.26 mm	1.95 mm shares	0.22	Common equity	Long	USA
EXEL Exelixis, Inc.	10.14 mm	278.05 k shares	0.21	Common equity	Long	USA
BBIO BridgeBio Pharma, Inc.	9.97 mm	367.90 k shares	0.21	Common equity	Long	USA
APLS Apellis Pharmaceuticals, Inc.	9.95 mm	293.26 k shares	0.21	Common equity	Long	USA
LEGN Legend Biotech Corporation	9.75 mm	231.81 k shares	0.21	Common equity	Long	Cayman Islands
UPB Upstream Bio, Inc.	9.64 mm	440.96 k shares	0.20	Common equity	Long	USA
GALDERMA GROUP AG	9.39 mm	91.67 k shares	0.20	Common equity	Long	Switzerland
ALEC Alector, Inc.	9.16 mm	3.54 mm shares	0.19	Common equity	Long	USA
ATYR aTyr Pharma, Inc.	8.91 mm	2.52 mm shares	0.19	Common equity	Long	USA
SWTX SpringWorks Therapeutics, Inc.	8.79 mm	211.91 k shares	0.19	Common equity	Long	USA
GPCR Structure Therapeutics Inc.	8.59 mm	259.18 k shares	0.18	Common equity	Long	Cayman Islands
METSERA INC SER B PC PP	8.50 mm	1.69 mm shares	0.18	Preferred equity	Long	USA
TWST Twist Bioscience Corporation	8.19 mm	166.53 k shares	0.17	Common equity	Long	USA
BCRX BioCryst Pharmaceuticals, Inc.	8.14 mm	1.08 mm shares	0.17	Common equity	Long	USA
SUMMIT THERAPEUTICS INC PIPE	8.13 mm	440.53 k shares	0.17	Common equity	Long	USA
SYRE Spyre Therapeutics, Inc.	8.10 mm	284.85 k shares	0.17	Common equity	Long	USA
SDGR Schrödinger, Inc.	7.92 mm	350.70 k shares	0.17	Common equity	Long	USA
SCORPION THERAPEUTICS INC SER B PC PP	7.50 mm	3.10 mm shares	0.16	Preferred equity	Long	USA
TRIVENI BIO INC SERIES B PC PP	7.45 mm	7.17 mm shares	0.16	Preferred equity	Long	USA
Arcturus Therapeutics Holdings, Inc.	7.32 mm	399.33 k shares	0.15	Common equity	Long	USA
QTTB Q32 Bio Inc.	6.99 mm	259.90 k shares	0.15	Common equity	Long	USA
Fidelity Cash Central Fund	6.98 mm	6.98 mm shares	0.15	Short-term investment vehicle	Long	USA
AXSM Axsome Therapeutics, Inc.	6.97 mm	71.00 k shares	0.15	Common equity	Long	USA
REPL Replimune Group, Inc.	6.68 mm	474.72 k shares	0.14	Common equity	Long	USA
IMCR Immunocore Holdings plc	6.28 mm	191.71 k shares	0.13	Common equity	Long	UK
TNYA Tenaya Therapeutics, Inc.	6.23 mm	1.75 mm shares	0.13	Common equity	Long	USA
ATXS Astria Therapeutics, Inc.	6.20 mm	596.26 k shares	0.13	Common equity	Long	USA
TRDA Entrada Therapeutics, Inc.	6.15 mm	309.17 k shares	0.13	Common equity	Long	USA
IGMS IGM Biosciences, Inc.	6.08 mm	605.81 k shares	0.13	Common equity	Long	USA
ALLO Allogene Therapeutics, Inc.	5.85 mm	2.36 mm shares	0.12	Common equity	Long	USA
ARWR Arrowhead Pharmaceuticals, Inc.	5.76 mm	221.12 k shares	0.12	Common equity	Long	USA
TYRA Tyra Biosciences, Inc.	5.69 mm	363.10 k shares	0.12	Common equity	Long	USA
GLUE Monte Rosa Therapeutics, Inc.	5.60 mm	540.52 k shares	0.12	Common equity	Long	USA
GOSS Gossamer Bio, Inc.	5.53 mm	7.91 mm shares	0.12	Common equity	Long	USA
NVO Novo Nordisk A/S	5.52 mm	51.70 k shares	0.12	Common equity	Long	Denmark
WAVE LIFE SCIENCES LTD	5.28 mm	349.81 k shares	0.11	Common equity	Long	Singapore
INZY Inozyme Pharma, Inc.	5.16 mm	1.90 mm shares	0.11	Common equity	Long	USA
BCAX Bicara Therapeutics Inc. Common Stock	5.05 mm	243.10 k shares	0.11	Common equity	Long	USA
DSGN Design Therapeutics, Inc.	5.03 mm	839.13 k shares	0.11	Common equity	Long	USA
CARDURION PHARMACEUTICALS INC SER B PC PP	5.00 mm	1.02 mm shares	0.11	Preferred equity	Long	USA
SCORPION THERAPEUTICS INC SERIES C1 PC PP	5.00 mm	2.07 mm shares	0.11	Preferred equity	Long	USA
FHTX Foghorn Therapeutics Inc.	4.81 mm	601.44 k shares	0.10	Common equity	Long	USA
IMNM Immunome, Inc.	4.77 mm	352.28 k shares	0.10	Common equity	Long	USA
RCKT Rocket Pharmaceuticals, Inc.	4.43 mm	307.69 k shares	0.09	Common equity	Long	USA
AMLX Amylyx Pharmaceuticals, Inc.	4.34 mm	782.81 k shares	0.09	Common equity	Long	USA
ITCI Intra-Cellular Therapies, Inc.	4.25 mm	49.60 k shares	0.09	Common equity	Long	USA
CLDX Celldex Therapeutics, Inc.	3.99 mm	145.46 k shares	0.08	Common equity	Long	USA
RAPP Rapport Therapeutics, Inc. Common Stock	3.92 mm	171.46 k shares	0.08	Common equity	Long	USA
CRGX CARGO Therapeutics, Inc. Common Stock	3.88 mm	213.40 k shares	0.08	Common equity	Long	USA
STOK Stoke Therapeutics, Inc.	3.83 mm	316.17 k shares	0.08	Common equity	Long	USA
AUTL Autolus Therapeutics plc	3.72 mm	1.12 mm shares	0.08	Common equity	Long	UK
DNTH Dianthus Therapeutics, Inc.	3.69 mm	153.69 k shares	0.08	Common equity	Long	USA
SEPN Septerna, Inc.	3.55 mm	140.20 k shares	0.07	Common equity	Long	USA
EXAS Exact Sciences Corporation	3.53 mm	56.90 k shares	0.07	Common equity	Long	USA
NMRA Neumora Therapeutics, Inc. Common Stock	3.51 mm	352.92 k shares	0.07	Common equity	Long	USA
CRESCENT BIOPHARMA INC PIPE	3.39 mm	12.10 mm shares	0.07	Common equity	Long	USA
GERN Geron Corporation	3.19 mm	2.10 mm shares	0.07	Common equity	Long	USA
ANAB AnaptysBio, Inc.	3.17 mm	127.17 k shares	0.07	Common equity	Long	USA
CATX Perspective Therapeutics, Inc.	3.10 mm	713.70 k shares	0.07	Common equity	Long	USA
ZBIO Zenas BioPharma, Inc.	3.06 mm	265.70 k shares	0.06	Common equity	Long	USA
VTVT vTv Therapeutics Inc.	2.85 mm	178.20 k shares	0.06	Common equity	Long	USA
BMEA Biomea Fusion, Inc.	2.84 mm	392.13 k shares	0.06	Common equity	Long	USA
KYMR Kymera Therapeutics, Inc.	2.81 mm	59.94 k shares	0.06	Common equity	Long	USA
THRD Third Harmonic Bio, Inc.	2.80 mm	219.60 k shares	0.06	Common equity	Long	USA
NGNE Neurogene Inc.	2.54 mm	99.86 k shares	0.05	Common equity	Long	USA
CGON CG Oncology, Inc. Common stock	2.50 mm	71.90 k shares	0.05	Common equity	Long	USA
PHARVARIS BV	2.46 mm	112.41 k shares	0.05	Common equity	Long	Netherlands
SRPT Sarepta Therapeutics, Inc.	2.36 mm	17.69 k shares	0.05	Common equity	Long	USA
RNAC Cartesian Therapeutics, Inc.	2.32 mm	5.39 mm shares	0.05	Common equity	Long	USA
AVIR Atea Pharmaceuticals, Inc.	2.28 mm	667.10 k shares	0.05	Common equity	Long	USA
HRMY Harmony Biosciences Holdings, Inc.	2.23 mm	64.43 k shares	0.05	Common equity	Long	USA
EWTX Edgewise Therapeutics, Inc.	2.01 mm	61.02 k shares	0.04	Common equity	Long	USA
ONC BeiGene, Ltd.	1.98 mm	9.20 k shares	0.04	Common equity	Long	Cayman Islands
JADE BIOSCIENCES INC PIPE	1.92 mm	345.92 k shares	0.04	Common equity	Long	USA
CANDID THERAPEUTICS INC SER B PC PP	1.83 mm	1.67 mm shares	0.04	Preferred equity	Long	USA
ANNX Annexon, Inc.	1.83 mm	339.69 k shares	0.04	Common equity	Long	USA
TXG 10x Genomics, Inc.	1.79 mm	112.40 k shares	0.04	Common equity	Long	USA
KORRO BIO INC PIPE	1.71 mm	32.87 k shares	0.04	Common equity	Long	USA
UNIQURE N.V.	1.65 mm	275.56 k shares	0.03	Common equity	Long	Netherlands
CAMP4 Therapeutics Corporation	1.26 mm	262.89 k shares	0.03	Common equity	Long	USA
BEAM Beam Therapeutics Inc.	1.08 mm	39.35 k shares	0.02	Common equity	Long	USA
RXRX Recursion Pharmaceuticals, Inc.	1.06 mm	149.90 k shares	0.02	Common equity	Long	USA
RAPT RAPT Therapeutics, Inc.	1.01 mm	802.70 k shares	0.02	Common equity	Long	USA
RYTM Rhythm Pharmaceuticals, Inc.	968.01 k	15.60 k shares	0.02	Common equity	Long	USA
CTNM Contineum Therapeutics, Inc. Class A Common Stock	876.71 k	58.80 k shares	0.02	Common equity	Long	USA
GKOS Glaukos Corporation	818.81 k	5.70 k shares	0.02	Common equity	Long	USA
LXRX Lexicon Pharmaceuticals, Inc.	809.81 k	1.01 mm shares	0.02	Common equity	Long	USA
SAGE Sage Therapeutics, Inc.	760.26 k	138.99 k shares	0.02	Common equity	Long	USA
ELEVATEBIO LLC SER C PC PP	628.14 k	216.60 k shares	0.01	Preferred equity	Long	USA
ASTRIA THERAPEUTICS INC WT	603.96 k	115.14 k shares	0.01	Common equity	Long	USA
SCHOLAR ROCK HOLDING CORP WT 12/31/2025 PP	586.80 k	17.85 k shares	0.01	Common equity	Long	USA
ADVM Adverum Biotechnologies, Inc.	486.13 k	73.21 k shares	0.01	Common equity	Long	USA
ARVN Arvinas, Inc.	400.67 k	15.00 k shares	0.01	Common equity	Long	USA
SALIOGEN THERAPEUTICS INC SER B PC PP	332.50 k	94.46 k shares	0.01	Preferred equity	Long	USA
IDORSIA LTD	282.63 k	289.34 k shares	0.01	Common equity	Long	Switzerland
AURA Aura Biosciences, Inc.	270.67 k	29.07 k shares	0.01	Common equity	Long	USA
NOVOCURE LTD	222.70 k	11.11 k shares	0.00	Common equity	Long	Jersey
VTYX Ventyx Biosciences, Inc.	218.69 k	81.60 k shares	0.00	Common equity	Long	USA
ABSI Absci Corporation	121.70 k	39.90 k shares	0.00	Common equity	Long	USA
BOLD Boundless Bio, Inc.	64.70 k	23.70 k shares	0.00	Common equity	Long	USA
CYCLERION THERAPEUTICS INC PP PIPE	10.43 k	4.74 k shares	0.00	Common equity	Long	USA
ORKA Oruka Therapeutics, Inc.	2.17 k	100.00 shares	0.00	Common equity	Long	USA
OPTN OptiNose, Inc.	1.24 k	91.71 k shares	0.00	Common equity	Long	USA
AFFERENT PHARMACEUTICALS INC SER C PC PP	82.75	8.27 mm shares	0.00	Preferred equity	Long	USA
AFFERENT PHARMACEUTICALS INC CONTINGENT VALUE RT 12/31/24	82.75	8.27 mm shares	0.00	Common equity	Long	USA
DISC MEDICINE INC CVR RT	15.56	1.56 mm shares	0.00	Common equity	Long	USA
GRITSTONE BIO INC WT	13.33	1.33 mm shares	0.00	Common equity	Long	USA
CDAKQ Codiak BioSciences, Inc.	4.49	448.54 k shares	0.00	Common equity	Long	USA
ARADIGM CORP PIPE	1.48	148.01 k shares	0.00	Common equity	Long	USA
CHINOOK THERAPEUTICS INC CVR RT	1.16	115.82 k shares	0.00	Common equity	Long	USA
ALNAQ Allena Pharmaceuticals, Inc.	0.94	93.68 k shares	0.00	Common equity	Long	USA
AXLA Axcella Health Inc.	0.66	66.45 k shares	0.00	Common equity	Long	USA
CODIAK BIOSCIENCES INC WT 09/15/2027	0.46	46.00 k shares	0.00	Common equity	Long	USA
ARADIGM CORP	0.12	11.95 k shares	0.00	Common equity	Long	USA
MEDAVAIL HOLDINGS INC PIPE	0.01	55.00 shares	0.00	Common equity	Long	USA