Select Biotechnology Portfolio

Fund Profile

Fund profile

Tickers

FBIOX

Fund manager

Fidelity Select Portfolios

Total assets

$5.81 bn

Liabilities

$464.35 mm

Net assets

$5.35 bn

Number of holdings

236.00

Top 200 of 236 Holdings

As of Nov 2022

Security	$Holding	Balance	% of Fund	Category	Position	Country
ABBV Abbvie Inc	583.13 mm	3.62 mm shares	10.90	Common equity	Long	USA
Fidelity Securities Lending Cash Central Fund	458.74 mm	458.70 mm shares	8.57	Short-term investment vehicle	Long	USA
ALNY Alnylam Pharmaceuticals Inc	242.68 mm	1.10 mm shares	4.54	Common equity	Long	USA
VRTX Vertex Pharmaceuticals, Inc.	224.58 mm	709.81 k shares	4.20	Common equity	Long	USA
BIIB Biogen Inc	214.55 mm	703.04 k shares	4.01	Common equity	Long	USA
REGN Regeneron Pharmaceuticals, Inc.	204.24 mm	271.71 k shares	3.82	Common equity	Long	USA
KRYS Krystal Biotech Inc	163.72 mm	2.11 mm shares	3.06	Common equity	Long	USA
ARGX Argen X SE	162.07 mm	407.25 k shares	3.03	Common equity	Long	Netherlands
MRNA Moderna Inc	161.55 mm	918.39 k shares	3.02	Common equity	Long	USA
UTHR United Therapeutics Corp	123.83 mm	442.41 k shares	2.31	Common equity	Long	USA
AMGN AMGEN Inc.	123.07 mm	429.70 k shares	2.30	Common equity	Long	USA
RCUS Arcus Biosciences Inc	112.31 mm	3.19 mm shares	2.10	Common equity	Long	USA
PTCT PTC Therapeutics Inc	94.10 mm	2.27 mm shares	1.76	Common equity	Long	USA
KRTX Karuna Therapeutics Inc	92.60 mm	393.51 k shares	1.73	Common equity	Long	USA
CYTK Cytokinetics Inc	91.57 mm	2.15 mm shares	1.71	Common equity	Long	USA
ADAP Adaptimmune Therapeutics Plc	81.15 mm	659.41 k shares	1.52	Common equity	Long	Denmark
BIO AB HOLDINGS LLC	78.75 mm	1.95 mm shares	1.47	Common equity	Long	USA
APLS Apellis Pharmaceuticals Inc	71.48 mm	1.43 mm shares	1.34	Common equity	Long	USA
BPMC Blueprint Medicines Corp	69.85 mm	1.46 mm shares	1.31	Common equity	Long	USA
SRPT Sarepta Therapeutics Inc	67.87 mm	552.60 k shares	1.27	Common equity	Long	USA
PCVX Vaxcyte Inc	62.42 mm	1.36 mm shares	1.17	Common equity	Long	USA
ARWR Arrowhead Pharmaceuticals Inc.	61.94 mm	1.92 mm shares	1.16	Common equity	Long	USA
MRTX Mirati Therapeutics Inc	60.51 mm	662.15 k shares	1.13	Common equity	Long	USA
BCRX Biocryst Pharmaceuticals Inc.	48.75 mm	3.65 mm shares	0.91	Common equity	Long	USA
PROTHENA CORP PLC	47.61 mm	761.59 k shares	0.89	Common equity	Long	Ireland
LEGN Legend Biotech Corp	47.01 mm	912.72 k shares	0.88	Common equity	Long	Cayman Islands
IONS Ionis Pharmaceuticals Inc	45.83 mm	1.12 mm shares	0.86	Common equity	Long	USA
NTLA Intellia Therapeutics Inc	45.54 mm	885.00 k shares	0.85	Common equity	Long	USA
BIOHAVEN LTD	44.67 mm	2.82 mm shares	0.83	Common equity	Long	Virgin Islands (British)
NATIONAL RESILIENCE INC SER B PC PP	44.46 mm	732.06 k shares	0.83	Preferred equity	Long	USA
SGEN Seagen Inc	43.43 mm	357.73 k shares	0.81	Common equity	Long	USA
GILD Gilead Sciences, Inc.	38.45 mm	437.80 k shares	0.72	Common equity	Long	USA
XENE Xenon Pharmaceuticals Inc	37.04 mm	1.00 mm shares	0.69	Common equity	Long	Canada
EXEL Exelixis Inc	35.91 mm	2.10 mm shares	0.67	Common equity	Long	USA
RARE Ultragenyx Pharmaceutical Inc.	35.51 mm	978.35 k shares	0.66	Common equity	Long	USA
BMRN Biomarin Pharmaceutical Inc. - Registered Shares	35.09 mm	347.45 k shares	0.66	Common equity	Long	USA
INCY Incyte Corp.	34.07 mm	427.60 k shares	0.64	Common equity	Long	USA
BNTX BioNTech SE	32.61 mm	195.23 k shares	0.61	Common equity	Long	Germany
HORIZON THERAPEUTICS PLC	32.11 mm	320.15 k shares	0.60	Common equity	Long	Ireland
ROIVANT SCIENCES LTD	31.93 mm	5.96 mm shares	0.60	Common equity	Long	Bermuda
KYMR Kymera Therapeutics Inc	31.09 mm	1.07 mm shares	0.58	Common equity	Long	USA
HALO Halozyme Therapeutics Inc.	30.45 mm	531.80 k shares	0.57	Common equity	Long	USA
CLDX Celldex Therapeutics Inc.	30.40 mm	819.70 k shares	0.57	Common equity	Long	USA
CERE Cerevel Therapeutics Holdings Inc	30.24 mm	1.04 mm shares	0.57	Common equity	Long	USA
ITCI Intra-Cellular Therapies Inc	30.24 mm	557.69 k shares	0.57	Common equity	Long	USA
MNKD Mannkind Corp	30.18 mm	6.45 mm shares	0.56	Common equity	Long	USA
SAGE Sage Therapeutics Inc	28.71 mm	699.55 k shares	0.54	Common equity	Long	USA
FOLD Amicus Therapeutics Inc	27.36 mm	2.26 mm shares	0.51	Common equity	Long	USA
BEAM Beam Therapeutics Inc	24.42 mm	528.69 k shares	0.46	Common equity	Long	USA
MORF Morphic Holding Inc	22.16 mm	805.34 k shares	0.41	Common equity	Long	USA
RYTM Rhythm Pharmaceuticals Inc.	22.12 mm	826.30 k shares	0.41	Common equity	Long	USA
CRNX Crinetics Pharmaceuticals Inc	21.08 mm	1.18 mm shares	0.39	Common equity	Long	USA
VTYX Ventyx Biosciences Inc	20.78 mm	716.63 k shares	0.39	Common equity	Long	USA
BLU Bellus Health Inc	20.42 mm	2.07 mm shares	0.38	Common equity	Long	Canada
KROS Keros Therapeutics Inc	18.89 mm	378.98 k shares	0.35	Common equity	Long	USA
REPL Replimune Group Inc	18.64 mm	910.82 k shares	0.35	Common equity	Long	USA
TWST Twist Bioscience Corp	18.63 mm	681.33 k shares	0.35	Common equity	Long	USA
OVID Ovid Therapeutics Inc	17.95 mm	845.67 k shares	0.34	Common equity	Long	USA
AXSM Axsome Therapeutics Inc	17.52 mm	242.37 k shares	0.33	Common equity	Long	USA
TGTX TG Therapeutics Inc	17.43 mm	1.98 mm shares	0.33	Common equity	Long	USA
ALKERMES PLC	17.04 mm	687.54 k shares	0.32	Common equity	Long	Ireland
IMCR Immunocore Holdings plc	16.79 mm	267.32 k shares	0.31	Common equity	Long	UK
CRISPR THERAPEUTICS AG	16.71 mm	305.02 k shares	0.31	Common equity	Long	Switzerland
ARVN Arvinas Inc	16.22 mm	395.24 k shares	0.30	Common equity	Long	USA
IDORSIA LTD	16.20 mm	1.09 mm shares	0.30	Common equity	Long	Switzerland
Arcturus Therapeutics Holdings, Inc.	16.15 mm	875.82 k shares	0.30	Common equity	Long	USA
DICE DICE Therapeutics Inc	15.73 mm	451.95 k shares	0.29	Common equity	Long	USA
EWTX Edgewise Therapeutics Inc	15.42 mm	1.72 mm shares	0.29	Common equity	Long	USA
ARQT Arcutis Biotherapeutics Inc	15.41 mm	894.17 k shares	0.29	Common equity	Long	USA
ALLO Allogene Therapeutics Inc	15.35 mm	1.56 mm shares	0.29	Common equity	Long	USA
RETA Reata Pharmaceuticals Inc	15.10 mm	381.63 k shares	0.28	Common equity	Long	USA
NTRA Natera Inc	14.64 mm	356.13 k shares	0.27	Common equity	Long	USA
GOSS Gossamer Bio Inc	14.44 mm	1.69 mm shares	0.27	Common equity	Long	USA
KNTE Kinnate Biopharma Inc	14.35 mm	1.81 mm shares	0.27	Common equity	Long	USA
COGT Cogent Biosciences Inc	14.34 mm	1.14 mm shares	0.27	Common equity	Long	USA
RLAY Relay Therapeutics Inc	14.32 mm	770.59 k shares	0.27	Common equity	Long	USA
ALXO Alx Oncology Holdings Inc	14.21 mm	1.28 mm shares	0.27	Common equity	Long	USA
ZNTL Zentalis Pharmaceuticals Inc	14.12 mm	638.43 k shares	0.26	Common equity	Long	USA
RXDX Prometheus Biosciences Inc	14.08 mm	342.56 k shares	0.26	Common equity	Long	USA
ROIVANT SCIENCES LTD PIPE	13.40 mm	2.50 mm shares	0.25	Common equity	Long	Bermuda
DNLI Denali Therapeutics Inc	13.33 mm	417.85 k shares	0.25	Common equity	Long	USA
RAPT RAPT Therapeutics Inc	13.27 mm	750.68 k shares	0.25	Common equity	Long	USA
SRRK Scholar Rock Holding Corp	13.16 mm	1.69 mm shares	0.25	Common equity	Long	USA
ISEE IVERIC bio Inc	13.12 mm	555.58 k shares	0.25	Common equity	Long	USA
NRIX Nurix Therapeutics Inc	13.09 mm	1.06 mm shares	0.24	Common equity	Long	USA
VERA Vera Therapeutics Inc	13.02 mm	779.77 k shares	0.24	Common equity	Long	USA
ACET Adicet Bio Inc	12.97 mm	713.36 k shares	0.24	Common equity	Long	USA
IDYA Ideaya Biosciences Inc	12.79 mm	715.16 k shares	0.24	Common equity	Long	USA
FATE Fate Therapeutics Inc	12.67 mm	608.79 k shares	0.24	Common equity	Long	USA
ROYALTY PHARMA PLC	12.57 mm	285.82 k shares	0.23	Common equity	Long	UK
IGMS IGM Biosciences Inc	12.35 mm	561.23 k shares	0.23	Common equity	Long	USA
THRX Theseus Pharmaceuticals Inc	12.24 mm	1.86 mm shares	0.23	Common equity	Long	USA
ACLX Arcellx Inc	12.07 mm	605.40 k shares	0.23	Common equity	Long	USA
INSM Insmed Inc	11.97 mm	647.39 k shares	0.22	Common equity	Long	USA
ENTA Enanta Pharmaceuticals Inc	11.56 mm	263.95 k shares	0.22	Common equity	Long	USA
FULC Fulcrum Therapeutics Inc	11.34 mm	1.66 mm shares	0.21	Common equity	Long	USA
DSGN Design Therapeutics Inc	11.29 mm	806.62 k shares	0.21	Common equity	Long	USA
SWTX SpringWorks Therapeutics Inc	11.21 mm	463.71 k shares	0.21	Common equity	Long	USA
TNGX Tango Therapeutics Inc	10.99 mm	1.46 mm shares	0.21	Common equity	Long	USA
BCYC Bicycle Therapeutics Plc	10.94 mm	377.65 k shares	0.20	Common equity	Long	UK
ZEALAND PHARMA A/S	10.75 mm	375.40 k shares	0.20	Common equity	Long	Denmark
MDGL Madrigal Pharmaceuticals Inc	10.74 mm	153.14 k shares	0.20	Common equity	Long	USA
GLUE Monte Rosa Therapeutics Inc	10.67 mm	1.26 mm shares	0.20	Common equity	Long	USA
SPRY ARS Pharmaceuticals Inc	10.42 mm	1.68 mm shares	0.19	Common equity	Long	USA
VALENZABIO INC SER A PC PP	9.99 mm	1.69 mm shares	0.19	Preferred equity	Long	USA
Fidelity Cash Central Fund	9.91 mm	9.91 mm shares	0.19	Short-term investment vehicle	Long	USA
RVMD Revolution Medicines Inc	9.88 mm	418.77 k shares	0.18	Common equity	Long	USA
JANX Janux Therapeutics Inc	9.80 mm	718.39 k shares	0.18	Common equity	Long	USA
UCB SA	9.79 mm	121.28 k shares	0.18	Common equity	Long	Belgium
GH RESEARCH PLC	9.77 mm	893.12 k shares	0.18	Common equity	Long	Ireland
CMPX Compass Therapeutics Inc	9.18 mm	2.23 mm shares	0.17	Common equity	Long	USA
RLYB Rallybio Corp	8.93 mm	1.55 mm shares	0.17	Common equity	Long	USA
IPSC Century Therapeutics Inc	8.76 mm	834.62 k shares	0.16	Common equity	Long	USA
AFFERENT PHARMACEUTICALS INC CONTINGENT VALUE RT 12/31/24	8.61 mm	8.27 mm shares	0.16	Common equity	Long	USA
HRMY Harmony Biosciences Holdings Inc	8.09 mm	135.33 k shares	0.15	Common equity	Long	USA
ALEC Alector Inc	7.76 mm	914.32 k shares	0.15	Common equity	Long	USA
PLRX Pliant Therapeutics Inc	7.68 mm	417.61 k shares	0.14	Common equity	Long	USA
INBX Inhibrx Inc	7.62 mm	254.31 k shares	0.14	Common equity	Long	USA
ANAB AnaptysBio Inc	7.55 mm	273.33 k shares	0.14	Common equity	Long	USA
TRDA Entrada Therapeutics Inc	7.54 mm	503.85 k shares	0.14	Common equity	Long	USA
AURA Aura Biosciences Inc	7.43 mm	519.96 k shares	0.14	Common equity	Long	USA
WAVE LIFE SCIENCES LTD	7.19 mm	1.70 mm shares	0.13	Common equity	Long	Singapore
NUVL Nuvalent Inc	7.19 mm	218.57 k shares	0.13	Common equity	Long	USA
SALIOGEN THERAPEUTICS INC SER B PC PP	7.04 mm	94.46 k shares	0.13	Preferred equity	Long	USA
MERUS B.V.	7.04 mm	458.69 k shares	0.13	Common equity	Long	Netherlands
KDNY Chinook Therapeutics Inc	6.88 mm	303.78 k shares	0.13	Common equity	Long	USA
UNIQURE N.V.	6.76 mm	255.61 k shares	0.13	Common equity	Long	Netherlands
PEPG PepGen Inc	6.59 mm	440.59 k shares	0.12	Common equity	Long	USA
ARISTEA THERAPEUTICS INC SER B PC PP	6.43 mm	836.40 k shares	0.12	Preferred equity	Long	USA
OMGA Omega Therapeutics Inc	6.41 mm	915.54 k shares	0.12	Common equity	Long	USA
ALVR AlloVir Inc	6.40 mm	852.38 k shares	0.12	Common equity	Long	USA
TERN Terns Pharmaceuticals Inc	6.30 mm	810.60 k shares	0.12	Common equity	Long	USA
ME 23andMe Holding Co	6.24 mm	2.05 mm shares	0.12	Common equity	Long	USA
TVTX Travere Therapeutics Inc	6.05 mm	300.43 k shares	0.11	Common equity	Long	USA
BTAI BioXcel Therapeutics Inc	5.83 mm	351.73 k shares	0.11	Common equity	Long	USA
VERV Verve Therapeutics Inc	5.79 mm	249.39 k shares	0.11	Common equity	Long	USA
ADVM Adverum Biotechnologies Inc	5.76 mm	8.60 mm shares	0.11	Common equity	Long	USA
BBIO BridgeBio Pharma Inc	5.75 mm	613.84 k shares	0.11	Common equity	Long	USA
MCRB Seres Therapeutics Inc	5.55 mm	854.35 k shares	0.10	Common equity	Long	USA
RNA Avidity Biosciences Inc	5.55 mm	476.75 k shares	0.10	Common equity	Long	USA
ALDX Aldeyra Therapeutics Inc	5.38 mm	961.34 k shares	0.10	Common equity	Long	USA
VRCA Verrica Pharmaceuticals Inc	5.19 mm	1.60 mm shares	0.10	Common equity	Long	USA
XNCR Xencor Inc	5.03 mm	169.34 k shares	0.09	Common equity	Long	USA
CNTA Centessa Pharmaceuticals plc	4.92 mm	1.23 mm shares	0.09	Common equity	Long	UK
ERAS Erasca Inc	4.83 mm	639.22 k shares	0.09	Common equity	Long	USA
ITOS ITeos Therapeutics Inc	4.80 mm	238.00 k shares	0.09	Common equity	Long	USA
IMGN Immunogen, Inc.	4.79 mm	922.02 k shares	0.09	Common equity	Long	USA
GH Guardant Health Inc	4.32 mm	82.50 k shares	0.08	Common equity	Long	USA
RCKT Rocket Pharmaceuticals Inc	4.22 mm	223.74 k shares	0.08	Common equity	Long	USA
CORT Corcept Therapeutics Inc	4.16 mm	164.40 k shares	0.08	Common equity	Long	USA
STRO Sutro Biopharma Inc	4.05 mm	540.10 k shares	0.08	Common equity	Long	USA
SCORPION THERAPEUTICS INC SER B PC PP	3.87 mm	3.10 mm shares	0.07	Preferred equity	Long	USA
RGLS Regulus Therapeutics Inc	3.75 mm	2.20 mm shares	0.07	Common equity	Long	USA
VRNA Verona Pharma Plc	3.74 mm	290.00 k shares	0.07	Common equity	Long	UK
GRPH Graphite Bio Inc	3.74 mm	1.06 mm shares	0.07	Common equity	Long	USA
DYN Dyne Therapeutics Inc	3.64 mm	310.81 k shares	0.07	Common equity	Long	USA
SDGR Schrodinger Inc	3.59 mm	199.43 k shares	0.07	Common equity	Long	USA
TNYA Tenaya Therapeutics Inc	3.35 mm	1.26 mm shares	0.06	Common equity	Long	USA
VOR Vor Biopharma Inc	3.20 mm	696.66 k shares	0.06	Common equity	Long	USA
KINIKSA PHARMACEUTICALS LTD	2.98 mm	177.17 k shares	0.06	Common equity	Long	Bermuda
APLT Applied Therapeutics Inc	2.96 mm	2.64 mm shares	0.06	Common equity	Long	USA
BMEA Biomea Fusion Inc	2.93 mm	407.13 k shares	0.05	Common equity	Long	USA
RPTX Repare Therapeutics Inc	2.80 mm	174.96 k shares	0.05	Common equity	Long	Canada
BIOINVENT AB	2.71 mm	788.71 k shares	0.05	Common equity	Long	Sweden
IRON Disc Medicine Inc	2.68 mm	1.56 mm shares	0.05	Common equity	Long	USA
PSTX Poseida Therapeutics Inc	2.60 mm	570.08 k shares	0.05	Common equity	Long	USA
FUSN Fusion Pharmaceuticals Inc	2.59 mm	1.14 mm shares	0.05	Common equity	Long	Canada
ABSI Absci Corp	2.49 mm	997.80 k shares	0.05	Common equity	Long	USA
LIFE Atyr Pharma Inc	2.48 mm	1.15 mm shares	0.05	Common equity	Long	USA
TRVI Trevi Therapeutics Inc	2.45 mm	1.30 mm shares	0.05	Common equity	Long	USA
TYRA Tyra Biosciences Inc	2.40 mm	342.20 k shares	0.04	Common equity	Long	USA
PRLD Prelude Therapeutics Inc	2.40 mm	359.16 k shares	0.04	Common equity	Long	USA
ADC THERAPEUTICS SA	2.33 mm	635.84 k shares	0.04	Common equity	Long	Switzerland
EVLO Evelo Biosciences Inc	2.30 mm	1.10 mm shares	0.04	Common equity	Long	USA
NKTX Nkarta Inc	2.08 mm	244.77 k shares	0.04	Common equity	Long	USA
LBPH Longboard Pharmaceuticals Inc	1.99 mm	371.10 k shares	0.04	Common equity	Long	USA
SEER Seer Inc	1.96 mm	304.06 k shares	0.04	Common equity	Long	USA
FHTX Foghorn Therapeutics Inc	1.95 mm	288.94 k shares	0.04	Common equity	Long	USA
TIL Instil Bio Inc	1.92 mm	1.45 mm shares	0.04	Common equity	Long	USA
EQRX EQRx Inc	1.91 mm	507.57 k shares	0.04	Common equity	Long	USA
KORRO BIO INC SER B-1 PC PP	1.83 mm	957.85 k shares	0.03	Preferred equity	Long	USA
TSHA Taysha Gene Therapies Inc	1.79 mm	811.65 k shares	0.03	Common equity	Long	USA
KORRO BIO INC SER B-2 PC PP	1.72 mm	899.28 k shares	0.03	Preferred equity	Long	USA
GTHX G1 Therapeutics Inc	1.65 mm	276.90 k shares	0.03	Common equity	Long	USA
ICVX Icosavax Inc	1.64 mm	490.86 k shares	0.03	Common equity	Long	USA
TSVT 2seventy bio Inc	1.63 mm	103.75 k shares	0.03	Common equity	Long	USA
RAIN Rain Oncology Inc	1.60 mm	206.67 k shares	0.03	Common equity	Long	USA
HOOK Hookipa Pharma Inc	1.57 mm	1.48 mm shares	0.03	Common equity	Long	USA
STOK Stoke Therapeutics Inc	1.53 mm	203.04 k shares	0.03	Common equity	Long	USA
AVTE Aerovate Therapeutics Inc	1.45 mm	77.05 k shares	0.03	Common equity	Long	USA
ALPHA TAU MEDICAL LTD CL A	1.44 mm	362.05 k shares	0.03	Common equity	Long	Israel
OPTN OptiNose Inc	1.41 mm	794.03 k shares	0.03	Common equity	Long	USA
GERN Geron Corp.	1.40 mm	2.10 mm shares	0.03	Common equity	Long	USA
AXLA Axcella Health Inc	1.40 mm	1.66 mm shares	0.03	Common equity	Long	USA
NUVB Nuvation Bio Inc	1.39 mm	727.40 k shares	0.03	Common equity	Long	USA
OLK Olink Holding AB (publ)	1.36 mm	57.10 k shares	0.03	Common equity	Long	Sweden
CADL Candel Therapeutics Inc	1.29 mm	737.60 k shares	0.02	Common equity	Long	USA
GRTS Gritstone Bio Inc	1.27 mm	431.58 k shares	0.02	Common equity	Long	USA
IMRX Immuneering Corp	1.24 mm	190.33 k shares	0.02	Common equity	Long	USA
SPRINGWORKS THERAPEUTICS INC PIPE	1.19 mm	54.80 k shares	0.02	Common equity	Long	USA